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  • 酸浆苦味B

    Physalin B

    酸浆苦味B
    产品编号 CFN92941
    CAS编号 23133-56-4
    分子式 = 分子量 C28H30O9 = 510.53
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The herbs of Physalis alkekengi
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    酸浆苦味B CFN92941 23133-56-4 1mg QQ客服:2159513211
    酸浆苦味B CFN92941 23133-56-4 5mg QQ客服:2159513211
    酸浆苦味B CFN92941 23133-56-4 10mg QQ客服:2159513211
    酸浆苦味B CFN92941 23133-56-4 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Auburn University2015, 1-58
  • Environ Toxicol.2020, doi: 10.1002
  • J Cell Biochem.2018, 119(2):2231-2239
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  • Exp Biol Med (Maywood).2019, 244(16):1463-1474
  • Natural Product Communications2023, 18(9).
  • Drug Chem Toxicol.2020, 1-12.
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  • Journal of Oil Palm Research2019, 31(2):238-247
  • J Korean Soc Food Sci Nutr2023, 52(11):1101-1110
  • Food Chem.2022, 373(Pt B):131364.
  • Molecules.2022, 27(22):7887.
  • Kor. J. Pharmacogn.2016, 47(1):62-72
  • Front Pharmacol.2020, 11:566490.
  • Applied Biological Chemistry2023, 66(58):112.
  • Separations2021, 8(6),80.
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  • ...
  • 生物活性
    Description: Physalin B shows antimalarial, anti-Trypanosoma cruzi, anti-bacterial, anti- leukemia activities, it has the potential to be developed as an effective chemotherapeutic lead compound for the treatment of malignant melanoma, it inhibits androgen-independent prostate cancer cell growth through activation of cell apoptosis and downregulation of androgen receptor expression. Physalin B exhibits a minimum inhibitory concentration value (MIC) against Mycobacterium tuberculosis H(37)Rv strain of 32 microg/mL. Physalin B also presents antinociceptive properties associated with central.
    Targets: Bcl-2/Bax | Caspase | Antifection | PAFR | JNK | ERK | TNF-α
    In vitro:
    J Nat Prod. 2011 Oct 28;74(10):2269-72.
    Antimalarial activity of physalins B, D, F, and G.[Pubmed: 21954931]

    METHODS AND RESULTS:
    The antimalarial activities of Physalin B, physalin D, physalin F, and physalin G (1-4), isolated from Physalis angulata, were investigated. In silico analysis using the similarity ensemble approach (SEA) database predicted the antimalarial activity of each of these compounds, which were shown using an in vitro assay against Plasmodium falciparum. However, treatment of P. berghei-infected mice with 3 increased parasitemia levels and mortality, whereas treatment with 2 was protective, causing a parasitemia reduction and a delay in mortality in P. berghei-infected mice.
    CONCLUSIONS:
    The exacerbation of in vivo infection by treatment with 3 is probably due to its potent immunosuppressive activity, which is not evident for 2.
    Anticancer Res. 1992 Jul-Aug;12(4):1155-62.
    Inhibitory effects of physalin B and physalin F on various human leukemia cells in vitro.[Pubmed: 1503404]

    METHODS AND RESULTS:
    Physalins B and F were isolated and characterized from the ethanolic extract of the whole plant of Physalis angulata L. (Solanaceae). Both Physalin B and physalin F inhibited the growth of several human leukemia cells: K562 (erythroleukemia), APM1840 (acute T lymphoid leukemia), HL-60 (acute promyelocytic leukemia), KG-1 (acute myeloid leukemia), CTV1 (acute monocytic leukemia) and B cell (acute B lymphoid leukemia). Physalin F showed a stronger activity against these leukemia cells than Physalin B, especially against acute myeloid leukemia (KG-1) and acute B lymphoid leukemia (B cell).
    CONCLUSIONS:
    From the structural features, the active site seems to be the functional epoxy group for physalin F and the double bond for Physalin B located at carbon 5 and 6; the former is much more active than the latter as regards anti-leukemic effects.
    Parasitology. 2013 Dec;140(14):1811-21.
    Physalins B and F, seco-steroids isolated from Physalis angulata L., strongly inhibit proliferation, ultrastructure and infectivity of Trypanosoma cruzi.[Pubmed: 24001147]
    We previously observed that physalins have immunomodulatory properties, as well as antileishmanial and antiplasmodial activities.
    METHODS AND RESULTS:
    Here, we investigated the anti-Trypanosoma cruzi activity of Physalin B, Physalin D, physalin F and physalin G. We found that Physalin B and physalin F were the most potent compounds against trypomastigote and epimastigote forms of T. cruzi. Electron microscopy of trypomastigotes incubated with Physalin B showed disruption of kinetoplast, alterations in Golgi apparatus and endoplasmic reticulum, followed by the formation of myelin-like figures, which were stained with MDC to confirm their autophagic vacuole identity. Physalin B-mediated alteration in Golgi apparatus was likely due to T. cruzi protease perturbation; however physalins did not inhibit activity of the trypanosomal protease cruzain. Flow cytometry examination showed that cell death is mainly caused by necrosis. Treatment with physalins reduced the invasion process, as well as intracellular parasite development in macrophage cell culture, with a potency similar to benznidazole. We observed that a combination of physalins and benznidazole has a greater anti-T. cruzi activity than when compounds were used alone.
    CONCLUSIONS:
    These results indicate that physalins, specifically B and F, are potent and selective trypanocidal agents. They cause structural alterations and induce autophagy, which ultimately lead to parasite cell death by a necrotic process.
    Phytother Res. 2002 Aug;16(5):445-8.
    Antimycobacterial physalins from Physalis angulata L. (Solanaceae).[Pubmed: 12203265 ]
    Crude extracts and fractions from aerial parts of Physalis angulata have been bioassayed for antimycobacterial activity.
    METHODS AND RESULTS:
    Fraction A1-29-12 containing Physalin B,physalin F and physalin D exhibited a minimum inhibitory concentration value (MIC) against Mycobacterium tuberculosis H(37)Rv strain of 32 microg/mL. Purified Physalin B and physalin D were also tested showing MIC values against Mycobacterium tuberculosis H(37)Rv strain of > 128 microg/mL and 32 microg/mL respectively, suggesting that physalin D plays a relevant role in the antimycobacterial activity displayed.
    CONCLUSIONS:
    Structural elucidation of both physalin D and Physalin B was based on detailed (13)C and (1)H NMR spectral analysis with the aid of 2D-correlation spectroscopy ((1)H-(1)H, COSY, HSQC and HMBC). The assignment of the (13)C chemical shift for physalin D is reported here for the first time.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9587 mL 9.7937 mL 19.5875 mL 39.175 mL 48.9687 mL
    5 mM 0.3917 mL 1.9587 mL 3.9175 mL 7.835 mL 9.7937 mL
    10 mM 0.1959 mL 0.9794 mL 1.9587 mL 3.9175 mL 4.8969 mL
    50 mM 0.0392 mL 0.1959 mL 0.3917 mL 0.7835 mL 0.9794 mL
    100 mM 0.0196 mL 0.0979 mL 0.1959 mL 0.3917 mL 0.4897 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异酸浆苦味素G; Isophysalin G CFN95328 152221-21-1 C28H30O10 = 526.5 5mg QQ客服:2159513211
    酸浆苦味H; Physalin H CFN92937 70241-09-7 C28H31ClO10 = 562.99 5mg QQ客服:3257982914
    4,7-二脱氢新酸浆苦素B; 4,7-Didehydroneophysalin B CFN95317 134461-76-0 C28H28O9 = 508.5 5mg QQ客服:2159513211
    酸浆苦味素X; Physalin X CFN95329 72497-31-5 C28H30O10 = 526.5 5mg QQ客服:1413575084
    根薯酮内酯A; Taccalonolide A CFN90596 108885-68-3 C36H46O14 = 702.74 10mg QQ客服:2056216494
    根薯酮内酯AJ; Taccalonolide AJ CFN90935 1349904-82-0 C34H44O14 = 676.7 5mg QQ客服:1457312923
    酸浆苦素L; Physalin L CFN90166 113146-74-0 C28H32O10 = 528.55 5mg QQ客服:1457312923
    酸浆苦味A; Physalin A CFN92940 23027-91-0 C28H30O10 = 526.5 5 mg QQ客服:2056216494
    酸浆苦素O; Physalin O CFN95097 120849-18-5 C28H32O10 = 528.55 5mg QQ客服:1413575084
    异酸浆苦味A; Isophysalin A CFN92936 1363398-67-7 C28H30O10 = 526.5 5mg QQ客服:1413575084

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