Info: Read More
  • 中药标准品生产商,产品定制服务
  • 酸浆苦味D

    Physalin D

    酸浆苦味D
    产品编号 CFN92939
    CAS编号 54980-22-2
    分子式 = 分子量 C28H32O11 = 544.55
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The herbs of Physalis alkekengi
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    酸浆苦味D CFN92939 54980-22-2 1mg QQ客服:1457312923
    酸浆苦味D CFN92939 54980-22-2 5mg QQ客服:1457312923
    酸浆苦味D CFN92939 54980-22-2 10mg QQ客服:1457312923
    酸浆苦味D CFN92939 54980-22-2 20mg QQ客服:1457312923
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of South Australia (Australia)
  • Korea Food Research Institute(KFRI) (Korea)
  • Macau University of Science and Technology (China)
  • University of Madras (India)
  • Center for protein Engineering (CIP) (Belgium)
  • Sant Gadge Baba Amravati University (India)
  • Kyoto University (Japan)
  • University of Dicle (Turkey)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Anna University (India)
  • Aarhus University (Denmark)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • Heidelberg University (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Tea Res. Ins. Of China2017, 1-12
  • Phys Chem Chem Phys.2018, 20(23):15986-15994
  • Food Funct.2022, 13(23):12105-12120.
  • Food Chemistry: X2023, 101032.
  • Nutrients.2023, 15(3):753.
  • Front Pharmacol.2017, 8:673
  • Evid Based Complement Alternat Med.2021, 2021:8707280.
  • Chemistry of Plant Raw Materials2022, 20220210569.
  • Phytochemistry Letters2015, 243-247
  • Analytical sci. & Tech2020, 33(5):224-231
  • Phytother Res.2018, 32(5):923-932
  • In Vivo.2022, 36(3):1136-1143.
  • Front Plant Sci.2022, 13:982771.
  • Sci. Rep.2015, 14-23
  • Research Square2020, doi: 10.21203.
  • Food Science and Biotechnology2023, 2023:1007
  • J Exp Bot.2016, 67(12):3777-88
  • National University of Pharmacy2022, 1:73-76
  • Phytomedicine.2021, 2(82):153452
  • Drug Des Devel Ther.2020, 14:5189-5204.
  • J Clin Med.2022, 11(13):3662.
  • Nutrients.2019, 12(1)
  • Analytical methods2019, 11(6)
  • ...
  • 生物活性
    Description: Physalin D shows antimalarial activity; it also exhibits a minimum inhibitory concentration value (MIC) against Mycobacterium tuberculosis H(37)Rv strain of 32 microg/mL. Physalin D displays considerable cytotoxicity against several cancer cell lines. It presents antinociceptive properties associated with central.
    Targets: TNF-α | Antifection
    In vitro:
    Parasitology. 2013 Dec;140(14):1811-21.
    Physalins B and F, seco-steroids isolated from Physalis angulata L., strongly inhibit proliferation, ultrastructure and infectivity of Trypanosoma cruzi.[Pubmed: 24001147]
    We previously observed that physalins have immunomodulatory properties, as well as antileishmanial and antiplasmodial activities.
    METHODS AND RESULTS:
    Here, we investigated the anti-Trypanosoma cruzi activity of physalin B, Physalin D, physalin F and physalin G. We found that physalin B and physalin F were the most potent compounds against trypomastigote and epimastigote forms of T. cruzi. Electron microscopy of trypomastigotes incubated with physalin B showed disruption of kinetoplast, alterations in Golgi apparatus and endoplasmic reticulum, followed by the formation of myelin-like figures, which were stained with MDC to confirm their autophagic vacuole identity. Physalin B-mediated alteration in Golgi apparatus was likely due to T. cruzi protease perturbation; however physalins did not inhibit activity of the trypanosomal protease cruzain. Flow cytometry examination showed that cell death is mainly caused by necrosis. Treatment with physalins reduced the invasion process, as well as intracellular parasite development in macrophage cell culture, with a potency similar to benznidazole. We observed that a combination of physalins and benznidazole has a greater anti-T. cruzi activity than when compounds were used alone.
    CONCLUSIONS:
    These results indicate that physalins, specifically B and F, are potent and selective trypanocidal agents. They cause structural alterations and induce autophagy, which ultimately lead to parasite cell death by a necrotic process.
    Phytother Res. 2002 Aug;16(5):445-8.
    Antimycobacterial physalins from Physalis angulata L. (Solanaceae).[Pubmed: 12203265]
    Crude extracts and fractions from aerial parts of Physalis angulata have been bioassayed for antimycobacterial activity.
    METHODS AND RESULTS:
    Fraction A1-29-12 containing Physalin B,physalin F and Physalin D exhibited a minimum inhibitory concentration value (MIC) against Mycobacterium tuberculosis H(37)Rv strain of 32 microg/mL. Purified Physalin B and Physalin D were also tested showing MIC values against Mycobacterium tuberculosis H(37)Rv strain of > 128 microg/mL and 32 microg/mL respectively, suggesting that Physalin D plays a relevant role in the antimycobacterial activity displayed.
    CONCLUSIONS:
    Structural elucidation of both Physalin D and Physalin B was based on detailed (13)C and (1)H NMR spectral analysis with the aid of 2D-correlation spectroscopy ((1)H-(1)H, COSY, HSQC and HMBC). The assignment of the (13)C chemical shift for Physalin D is reported here for the first time.
    In vivo:
    J Nat Prod. 2011 Oct 28;74(10):2269-72.
    Antimalarial activity of physalins B, D, F, and G.[Pubmed: 21954931]
    The antimalarial activities of Physalin B, Physalin D, physalin F, and physalin G (1-4), isolated from Physalis angulata, were investigated.
    METHODS AND RESULTS:
    In silico analysis using the similarity ensemble approach (SEA) database predicted the antimalarial activity of each of these compounds, which were shown using an in vitro assay against Plasmodium falciparum. However, treatment of P. berghei-infected mice with 3 increased parasitemia levels and mortality, whereas treatment with 2 was protective, causing a parasitemia reduction and a delay in mortality in P. berghei-infected mice.
    CONCLUSIONS:
    The exacerbation of in vivo infection by treatment with 3 is probably due to its potent immunosuppressive activity, which is not evident for 2.
    J Pharm Pharmacol. 2006 Feb;58(2):235-41.
    In-vitro and in-vivo antitumour activity of physalins B and D from Physalis angulata.[Pubmed: 16451752 ]
    We have evaluated the in-vitro and in-vivo antitumour activity of physalin B and Physalin D isolated from the aerial parts of Physalis angulata.
    METHODS AND RESULTS:
    In-vitro, both compounds displayed considerable cytotoxicity against several cancer cell lines, showing IC50 values in the range of 0.58 to 15.18 microg mL(-1) for physalin B, and 0.28 to 2.43 microg mL(-1) for Physalin D. The antitumour activity of both compounds was confirmed in-vivo using mice bearing sarcoma 180 tumour cells. The in-vivo antitumour activity was related to the inhibition of tumour proliferation, as observed by the reduction of Ki67 staining in tumours of treated animals. Histopathological examination of the kidney and liver showed that both organs were affected by physalin treatment, but in a reversible manner.
    CONCLUSIONS:
    These compounds were probably responsible for the previously described antitumour activity of ethanol extracts of P. angulata, and their identification and characterization presented here could explain the ethnopharmacological use of this species in the treatment of cancer.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8364 mL 9.1819 mL 18.3638 mL 36.7276 mL 45.9095 mL
    5 mM 0.3673 mL 1.8364 mL 3.6728 mL 7.3455 mL 9.1819 mL
    10 mM 0.1836 mL 0.9182 mL 1.8364 mL 3.6728 mL 4.5909 mL
    50 mM 0.0367 mL 0.1836 mL 0.3673 mL 0.7346 mL 0.9182 mL
    100 mM 0.0184 mL 0.0918 mL 0.1836 mL 0.3673 mL 0.4591 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    酸浆苦味A; Physalin A CFN92940 23027-91-0 C28H30O10 = 526.5 5 mg QQ客服:2056216494
    酸浆苦素O; Physalin O CFN95097 120849-18-5 C28H32O10 = 528.55 5mg QQ客服:1413575084
    异酸浆苦味A; Isophysalin A CFN92936 1363398-67-7 C28H30O10 = 526.5 5mg QQ客服:2159513211
    酸浆苦味C; Physalin C CFN92938 27503-33-9 C28H30O9 = 510.53 5mg QQ客服:1413575084
    酸浆苦味B; Physalin B CFN92941 23133-56-4 C28H30O9 = 510.53 5mg QQ客服:1457312923
    酸浆苦味D; Physalin D CFN92939 54980-22-2 C28H32O11 = 544.55 5mg QQ客服:215959384
    酸浆苦味素F; Physalin F CFN91811 57423-71-9 C28H30O10 = 526.5 10mg QQ客服:1413575084
    酸浆苦味素G; Physalin G CFN95104 76045-38-0 C28H30O10 = 526.5 5mg QQ客服:1413575084
    异酸浆苦味素G; Isophysalin G CFN95328 152221-21-1 C28H30O10 = 526.5 5mg QQ客服:3257982914
    酸浆苦味H; Physalin H CFN92937 70241-09-7 C28H31ClO10 = 562.99 5mg QQ客服:215959384

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产