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  • 丁香树脂酚

    Syringaresinol

    丁香树脂酚
    产品编号 CFN92060
    CAS编号 487-35-4
    分子式 = 分子量 C22H26O8 = 418.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The branch of Liriodendron chinensis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    丁香树脂酚 CFN92060 487-35-4 1mg QQ客服:2932563308
    丁香树脂酚 CFN92060 487-35-4 5mg QQ客服:2932563308
    丁香树脂酚 CFN92060 487-35-4 10mg QQ客服:2932563308
    丁香树脂酚 CFN92060 487-35-4 20mg QQ客服:2932563308
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • John Innes Centre (United Kingdom)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • University of Liège (Belgium)
  • Rio de Janeiro State University (Brazil)
  • MTT Agrifood Research Finland (Finland)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Medizinische Universit?t Wien (Austria)
  • Universidade Federal de Santa Catarina (Brazil)
  • Kyoto University (Japan)
  • Lund University (Sweden)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • Chinese University of Hong Kong (China)
  • Seoul National University (Korea)
  • University of Illinois (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Crystals2020, 10(3), 206.
  • Molecules.2019, 24(7):E1290
  • Chem Pharm Bull (Tokyo).2017, 65(9):826-832
  • J of L. Chroma.&Related Tech2017, 252-258
  • The Korea Journal of Herbology2016, 29-35
  • Life Sci.2021, 270:119074.
  • J Insect Sci.2020, 20(5):18.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2018, 1080:27-36
  • Natural Product Communications2021, 16(9):1-10.
  • Molecules2022, 27(3),1140.
  • Chinese J of Tissue Engineering Res.2022, 26(17): 2636-2641.
  • Int J Mol Sci.2022, 23(13):7115.
  • Int J Mol Sci.2020, 21(8):2790.
  • Korean J Environ Agric.2018, 37(4):260-267
  • Trop J Nat Prod Res.2019, 3(1):6-9
  • BMC Complement Altern Med.2017, 17(1):384
  • J Agric Food Chem.2018, 66(1):351-358
  • Arch Biochem Biophys.2020, 687:108384.
  • Front Microbiol.2022, 13:835463.
  • Br J Pharmacol.2016, 173(2):396-410
  • Biochem Biophys Res Commun.2018, 505(1):261-266
  • Int. J. of Food Properties2017, S108-S118
  • J Nat Prod.2019, 82(4):1002-1008
  • ...
  • 生物活性
    Description: (-)-Syringaresinol may be a potential chemotherapeutic agent for the treatment of cancer; it against H/R-induced cardiomyocyte injury and death, the degradation of HIF-1α through activation of FOXO3 is a potential therapeutic strategy for ischemia-related diseases. Syringaresinol induces vasorelaxation by enhancing NO production in endothelial cells via two distinct mechanisms, phosphatidylinositol 3-kinase/Akt- and PLC/Ca(2+)/CaMKKβ-dependent eNOS phosphorylation and Ca(2+)-dependent eNOS dimerization.
    Targets: HIF | mTOR | ROS | NO | NOS | Akt | AMPK | Calcium Channel | PI3K | CDK | p21 | Bcl-2/Bax | PARP | Caspase
    In vitro:
    Oncotarget. 2015 Jan 1;6(1):43-55.
    Syringaresinol protects against hypoxia/reoxygenation-induced cardiomyocytes injury and death by destabilization of HIF-1α in a FOXO3-dependent mechanism.[Pubmed: 25415049]
    Hypoxia-inducible factor 1 (HIF-1) is a master regulator of hypoxic response and has been a prime therapeutic target for ischemia/reperfusion (I/R)-derived myocardial dysfunction and tissue damage. There is also increasing evidence that HIF-1 plays a central role in regulating aging, both through interactions with key longevity factors including Sirtuins and mTOR, as well as by directly promoting longevity in Caenorhabditis elegans.
    METHODS AND RESULTS:
    We investigated a novel function and the underlying mechanism of Syringaresinol, a lignan compound, in modulation of HIF-1 and protection against cellular damage and death in a cardiomyocyte model of I/R injury. Syringaresinol caused destabilization of HIF-1α following H/R and then protected against hypoxia/reoxygenation (H/R)-induced cellular damage, apoptosis, and mitochondrial dysfunction in a dose-dependent manner. Knock-down of FOXO3 by specific siRNAs completely abolished the ability of Syringaresinol to inhibit HIF-1 stabilization and apoptosis caused by H/R. Syringaresinol stimulated the nuclear localization and activity of FOXO3 leading to increased expression of antioxidant genes and decreased levels of reactive oxygen species (ROS) following H/R.
    CONCLUSIONS:
    Our results provide a new mechanistic insight into a functional role of Syringaresinol against H/R-induced cardiomyocyte injury and death. The degradation of HIF-1α through activation of FOXO3 is a potential therapeutic strategy for ischemia-related diseases.
    Int Immunopharmacol. 2008 Jul;8(7):967-73.
    (-)-Syringaresinol inhibits proliferation of human promyelocytic HL-60 leukemia cells via G1 arrest and apoptosis.[Pubmed: 18486907]

    METHODS AND RESULTS:
    We examined the effect of (-)-syringaresinol, a furofuran-type lignan isolated from Daphne genkwa, on cell cycle regulation in HL-60 human promyelocytic leukemia cells in vitro. (-)-Syringaresinol decreased the viability of HL-60 cells by inducing G(1) arrest followed by apoptosis in a dose- and time-dependent manner. The G(0)/G(1) phase of the cell cycle is regulated by cyclin-dependent kinases (Cdk), cyclins and cyclin-dependent kinase inhibitors (Cdki). We show by western blot analysis, that the (-)-syringaresinol-induced G(1) arrest was mediated through the increased expression of Cdki proteins (p21(cip1/waf1) and p27(kip1)) with a simultaneous decrease in cdk2, cdk4, cdk6, cyclin D(1), cyclin D(2), and cyclin E expression. The induction of apoptosis after treatment with (-)-syringaresinol for 24 h was demonstrated by morphological changes, DNA fragmentation, altered ratio of Bax/Bcl-2, cleavage of poly(ADP-ribose) polymerase and flow cytometry analysis. (-)-Syringaresinol also induced cytochrome c release and activation of caspase-3 and caspase-9. To our knowledge, this is the first time that (-)-syringaresinol has been reported to potently inhibit the proliferation of human promyelocytic HL-60 cells through G(1) arrest and induction of apoptosis.
    CONCLUSIONS:
    These findings suggest that (-)-syringaresinol may be a potential chemotherapeutic agent for the treatment of cancer.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3901 mL 11.9503 mL 23.9006 mL 47.8011 mL 59.7514 mL
    5 mM 0.478 mL 2.3901 mL 4.7801 mL 9.5602 mL 11.9503 mL
    10 mM 0.239 mL 1.195 mL 2.3901 mL 4.7801 mL 5.9751 mL
    50 mM 0.0478 mL 0.239 mL 0.478 mL 0.956 mL 1.195 mL
    100 mM 0.0239 mL 0.1195 mL 0.239 mL 0.478 mL 0.5975 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    De-4'-O-methylyangambin; De-4'-O-methylyangambin CFN99618 149250-48-6 C23H28O8 = 432.5 5mg QQ客服:1148253675
    鹅掌楸树脂醇 A ; Episyringaresinol CFN96717 51152-20-6 C22H26O8 = 418.44 5mg QQ客服:3257982914
    DL-丁香树脂酚; DL-Syringaresinol CFN99276 1177-14-6 C22H26O8 = 418.4 5mg QQ客服:215959384
    丁香树脂酚; Syringaresinol CFN92060 487-35-4 C22H26O8 = 418.4 10mg QQ客服:1148253675
    二乙酸丁香树脂醇酯; Syringaresinol diacetate CFN98009 1990-77-8 C26H30O10 = 502.5 5mg QQ客服:215959384
    刺五加甙E1; Acanthoside B CFN97220 7374-79-0 C28H36O13 = 580.6 10mg QQ客服:2932563308
    (-)-丁香树脂醇二葡萄糖甙; 丁香树脂醇双葡萄糖苷; Syringaresinol-di-O-glucoside CFN90458 66791-77-3 C34H46O18 = 742.71 20mg QQ客服:1148253675
    鹅掌楸苦素; Liriodendrin CFN98964 573-44-4 C34H46O18 = 742.7 5mg QQ客服:1413575084

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