DL-丁香树脂酚

DL-Syringaresinol

	产品编号	CFN99276
	CAS编号	1177-14-6
	分子式 = 分子量	C₂₂H₂₆O₈ = 418.4
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Lignans
	植物来源	The herbs of Liriodendron tulipifera
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
DL-丁香树脂酚	CFN99276	1177-14-6	1mg	QQ客服：3257982914
DL-丁香树脂酚	CFN99276	1177-14-6	5mg	QQ客服：3257982914
DL-丁香树脂酚	CFN99276	1177-14-6	10mg	QQ客服：3257982914
DL-丁香树脂酚	CFN99276	1177-14-6	20mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Max-Planck-Insitut (Germany)

Leibniz Institute of Plant Biochemistry (Germany)

Celltrion Chemical Research Institute (Korea)

Max Rubner-Institut (MRI) (Germany)

University of Canterbury (New Zealand)

Helmholtz Zentrum München (Germany)

University of Amsterdam (Netherlands)

Aarhus University (Denmark)

Anna University (India)

Universidade da Beira Interior (Germany)

Korea Intitute of Science and Technology (KIST) (Korea)

Osmania University (India)

University of Queensland (Australia)

Nicolaus Copernicus Uniwersity (Poland)

More...

Description:

(+)-Syringaresinol shows inhibitory activity of Helicobacter pylori motility with the IC50 value is 50 microg/ml. (-)-Syringaresinol has been reported to potently inhibit the proliferation of human promyelocytic HL-60 cells through G 1 arrest and induction of apoptosis, suggests that it may be a potential chemotherapeutic agent for the treatment of cancer. Syringaresinol induces vasorelaxation by enhancing NO production in endothelial cells via two distinct mechanisms, phosphatidylinositol 3-kinase/Akt- and (PLC)/Ca2+/CaMKKβ -dependent eNOS phosphorylation and Ca(2+)-dependent eNOS dimerization. Syringaresinol also can protect against hypoxia/reoxygenation-induced cardiomyocytes injury and death by destabilization of HIF-1α in a FOXO3-dependent mechanism.

Targets:

Antifection | PI3K | Akt | Calcium Channel | NOS | HIF | NO

In vitro:

Biol Pharm Bull. 2006 Jan;29(1):172-3.

Inhibition of Helicobacter pylori motility by (+)-Syringaresinol from unripe Japanese aprico[Pubmed: 16394533]

METHODS AND RESULTS:
A methanol extract from unripe Japanese apricot showed inhibitory activity of Helicobacter pylori motility. Inhibitory compound 1 was isolated and identified as (+)-syringaresinol (1) by spectoroscopic means. (+)-Syringaresinol (1) inhibited >90% of the H. pylori motility at a concentration of 500 microg/ml and the IC50 value was 50 microg/ml.

Int Immunopharmacol. 2008 Jul;8(7):967-73.

(-)-Syringaresinol inhibits proliferation of human promyelocytic HL-60 leukemia cells via G1 arrest and apoptosis.[Pubmed: 18486907]

METHODS AND RESULTS:
The induction of apoptosis after treatment with (-)-syringaresinol for 24 h was demonstrated by morphological changes, DNA fragmentation, altered ratio of Bax/Bcl-2, cleavage of poly(ADP-ribose) polymerase and flow cytometry analysis. (-)-Syringaresinol also induced cytochrome c release and activation of caspase-3 and caspase-9. To our knowledge, this is the first time that (-)-syringaresinol has been reported to potently inhibit the proliferation of human promyelocytic HL-60 cells through G(1) arrest and induction of apoptosis.
CONCLUSIONS:
These findings suggest that (-)-syringaresinol may be a potential chemotherapeutic agent for the treatment of cancer.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
De-4'-O-methylyangambin; De-4'-O-methylyangambin	CFN99618	149250-48-6	C₂₃H₂₈O₈ = 432.5	5mg	QQ客服：3257982914
鹅掌楸树脂醇 A ; Episyringaresinol	CFN96717	51152-20-6	C₂₂H₂₆O₈ = 418.44	5mg	QQ客服：1413575084
DL-丁香树脂酚; DL-Syringaresinol	CFN99276	1177-14-6	C₂₂H₂₆O₈ = 418.4	5mg	QQ客服：1413575084
丁香树脂酚; Syringaresinol	CFN92060	487-35-4	C₂₂H₂₆O₈ = 418.4	10mg	QQ客服：3257982914
二乙酸丁香树脂醇酯; Syringaresinol diacetate	CFN98009	1990-77-8	C₂₆H₃₀O₁₀ = 502.5	5mg	QQ客服：215959384
刺五加甙E1; Acanthoside B	CFN97220	7374-79-0	C₂₈H₃₆O₁₃ = 580.6	20mg	QQ客服：3257982914
(-)-丁香树脂醇二葡萄糖甙; 丁香树脂醇双葡萄糖苷; Syringaresinol-di-O-glucoside	CFN90458	66791-77-3	C₃₄H₄₆O₁₈ = 742.71	20mg	QQ客服：3257982914
鹅掌楸苦素; Liriodendrin	CFN98964	573-44-4	C₃₄H₄₆O₁₈ = 742.7	5mg	QQ客服：215959384

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.3901 mL	11.9503 mL	23.9006 mL	47.8011 mL	59.7514 mL
5 mM	0.478 mL	2.3901 mL	4.7801 mL	9.5602 mL	11.9503 mL
10 mM	0.239 mL	1.195 mL	2.3901 mL	4.7801 mL	5.9751 mL
50 mM	0.0478 mL	0.239 mL	0.478 mL	0.956 mL	1.195 mL
100 mM	0.0239 mL	0.1195 mL	0.239 mL	0.478 mL	0.5975 mL