西门肺草碱

Symphytine

	产品编号	CFN00262
	CAS编号	22571-95-5
	分子式 = 分子量	C₂₀H₃₁NO₆ = 381.47
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源	The herbs of Symphytum peregrinum Leded.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
西门肺草碱	CFN00262	22571-95-5	1mg	QQ客服：215959384
西门肺草碱	CFN00262	22571-95-5	5mg	QQ客服：215959384
西门肺草碱	CFN00262	22571-95-5	10mg	QQ客服：215959384
西门肺草碱	CFN00262	22571-95-5	20mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Medicine and Pharmacy (Romania)

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Georgia Institute of Technology (USA)

Warszawski Uniwersytet Medyczny (Poland)

University of Illinois at Chicago (USA)

Griffith University (Australia)

University of Hawaii Cancer Center (USA)

Chang Gung University (Taiwan)

Lund University (Sweden)

Max-Planck-Insitut (Germany)

VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)

Helmholtz Zentrum München (Germany)

St. Jude Children Research Hospital (USA)

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Description:

Symphytine and senkirkine, the pyrrolizidine alkaloids, have carcinogenicity.

In vitro:

Public Health Nutr. 2004 Oct;7(7):919-24.

Analysis of herbal teas made from the leaves of comfrey (Symphytum officinale): reduction of N-oxides results in order of magnitude increases in the measurable concentration of pyrrolizidine alkaloids.[Pubmed: 15482618]

To determine the relative quantities of two hepatotoxic pyrrolizidine alkaloids, symphytine and echimidine, in teas prepared from comfrey leaves (Symphytum officinale), and to determine the potential contribution of the N-oxide forms of these alkaloids to levels of the parent alkaloids.
METHODS AND RESULTS:
Comfrey leaves were purchased from three commercial sources and used to prepare tea in a manner consistent with the methods used by consumers. An extraction scheme was devised for extraction of the alkaloids, and a gas chromatographic method was developed to quantify the two major alkaloids, symphytine and echimidine. Recognising that the N-oxide derivatives of these alkaloids have also been identified in comfrey preparations, chemical reduction was applied to determine the total quantities of the alkaloids as free bases and as N-oxide derivatives. The concentration of symphytine and echimidine varied considerably between teas prepared from leaves purchased from the different vendors of plant material. Moreover, a much higher concentration of symphytine was found in the tea when steps were included to reduce N-oxides prior to analysis. The treatment of pure symphytine with hot water did not generate the N-oxide derivative de novo.
CONCLUSIONS:
Since the pyrrolizidine alkaloids are known to be hepatotoxic, consumption of herbal teas made from comfrey leaves may be ill-advised. The concentration of pyrrolizidine alkaloids in such teas may be underestimated substantially unless the concentration of N-oxides is taken into consideration.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
欧天芥菜碱; Europine	CFN00264	570-19-4	C₁₆H₂₇NO₆ = 329.39	5mg	QQ客服：2159513211
欧天芥菜碱氮氧化物; Europine N-oxide	CFN00265	65582-53-8	C₁₆H₂₇NO₇ = 345.39	5mg	QQ客服：2056216494
阔叶碱; Latifoline	CFN00266	6029-86-3	C₂₀H₂₇NO₇ = 393.44	5mg	QQ客服：1457312923
阔叶碱N-氧化物; Latifoline N-oxide	CFN00267	98752-06-8	C₂₀H₂₇NO₈ = 409.43	5mg	QQ客服：1457312923
天芥菜品碱; Heliosupine	CFN00268	32728-78-2	C₂₀H₃₁NO₇ = 397.47	5mg	QQ客服：3257982914
天芥菜品碱N-氧化物; Heliosupine N-oxide	CFN00454	31701-88-9	C₂₀H₃₁NO₈ = 413.5	5mg	QQ客服：1457312923
乙酰天芥菜品碱; Acetylheliosupine	CFN00269	31514-30-4	C₂₂H₃₃NO₈ = 439.50	5mg	QQ客服：1413575084
天芥菜碱; Heliotrine	CFN00270	303-33-3	C₁₆H₂₇NO₅ = 313.39	5mg	QQ客服：215959384
天芥菜碱 N-氧化物; Heliotrine N-oxide	CFN00271	6209-65-0	C₁₆H₂₇NO₆ = 329.39	5mg	QQ客服：1457312923
大叶千里光碱; Macrophylline	CFN00275	27841-97-0	C₁₃H₂₁NO₃ = 239.31	5mg	QQ客服：2159513211

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.6214 mL	13.1072 mL	26.2144 mL	52.4288 mL	65.536 mL
5 mM	0.5243 mL	2.6214 mL	5.2429 mL	10.4858 mL	13.1072 mL
10 mM	0.2621 mL	1.3107 mL	2.6214 mL	5.2429 mL	6.5536 mL
50 mM	0.0524 mL	0.2621 mL	0.5243 mL	1.0486 mL	1.3107 mL
100 mM	0.0262 mL	0.1311 mL	0.2621 mL	0.5243 mL	0.6554 mL