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  • 日当药黄素,日本当药黄素,日本獐牙菜素

    Swertiajaponin

    日当药黄素,日本当药黄素,日本獐牙菜素
    产品编号 CFN90652
    CAS编号 6980-25-2
    分子式 = 分子量 C22H22O11 = 462.4
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Swertia mileensis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    日当药黄素,日本当药黄素,日本獐牙菜素 CFN90652 6980-25-2 1mg QQ客服:215959384
    日当药黄素,日本当药黄素,日本獐牙菜素 CFN90652 6980-25-2 5mg QQ客服:215959384
    日当药黄素,日本当药黄素,日本獐牙菜素 CFN90652 6980-25-2 10mg QQ客服:215959384
    日当药黄素,日本当药黄素,日本獐牙菜素 CFN90652 6980-25-2 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidade de Franca (Brazil)
  • Rio de Janeiro State University (Brazil)
  • Universitas islam negeri Jakarta (Indonesia)
  • University of Helsinki (Finland)
  • Medical University of Gdansk (Poland)
  • CSIRO - Agriculture Flagship (Australia)
  • Kamphaengphet Rajabhat University (Thailand)
  • Max-Planck-Insitut (Germany)
  • John Innes Centre (United Kingdom)
  • Universidad de La Salle (Mexico)
  • University of Indonesia (Indonesia)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • Texas A&M University (USA)
  • National Hellenic Research Foundation (Greece)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Chem.2020, 327:126992.
  • Molecules.2019, 24(21):E3834
  • Sci Rep. 2017, 8207(7)
  • Antioxidants2022, 11(2),234.
  • Int J Food Sci Nutr.2019, 70(7):825-833
  • Plants (Basel).2021, 10(11):2525.
  • Chin J Pharm Anal.2019, 39(7):1217-1228
  • Anal Bioanal Chem. 2016, 408(15)
  • Food Chem.2019, 290:286-294
  • Antioxidants (Basel).2020, 9(6):526.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1126-1127:121743
  • Biosci Biotechnol Biochem.2020, 84(3):621-632
  • Fitoterapia.2015, 100:179-86
  • Phytomedicine.2021, 2(82):153452
  • J Ethnopharmacol.2019, 244:112074
  • Molecules.2022, 27(7):2093.
  • Acta Agriculturae Scandinavica2015, 381-383
  • Molecules.2019, 24(7):E1290
  • Front Plant Sci.2020, 10:1705
  • Nutrients.2019, 11(11):E2694
  • Evid Based Complement Alternat Med.2017, 2017:6360836
  • Antioxidants (Basel).2020, 9(6):466.
  • J Ginseng Res.2022, 46(1):104-114.
  • ...
  • 生物活性
    Description: Swertiajaponin possesses antimicrobial activity.
    Targets: Antifection
    In vitro:
    Molecules. 2009 Sep 30;14(10):3906-13.
    Inhibitory effect of three C-glycosylflavonoids from Cymbopogon citratus (Lemongrass) on human low density lipoprotein oxidation.[Pubmed: 19924037]
    This study assessed the inhibitory effect of three C-glycosylflavonoids from Cymbopogon citratus leaves--isoorientin (1), Swertiajaponin (2) and isoorientin 2"-Orhamnoside (3)--on human LDL oxidation.
    METHODS AND RESULTS:
    Isolated LDL was incubated with compounds 1-3 and the kinetics of lipid peroxidation were assessed by conjugated diene and malondialdehyde-thiobarbituric acid reactive substances (MDA-TBARS) formation after addition of copper ions. Significant differences (p < 0.05) between the lag time phase of the control and the lag time phase in the presence of the compounds 1 (0.25 microM) and 2 (0.50 microM) were observed. After five hours of incubation all three compounds showed a significant inhibitory effect on MDA-TBARS formation with respect to the control. After six hours of incubation only compound 1 kept a remarkable antioxidant effect.
    CONCLUSIONS:
    This study demonstrates that isoorientin (1) is an effective inhibitor of in vitro LDL oxidation. As oxidative damage to LDL is a key event in the formation of atherosclerotic lesions, the use of this natural antioxidant may be beneficial to prevent or attenuate atherosclerosis.
    J Agric Food Chem. 2005 Apr 6;53(7):2511-7.
    Free radical scavengers and antioxidants from Lemongrass (Cymbopogon citratus (DC.) Stapf.).[Pubmed: 15796587]

    METHODS AND RESULTS:
    Methanol, MeOH/water extracts, infusion, and decoction of Cymbopogon citratus were assessed for free radical scavenging effects measured by the bleaching of the 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical, scavenging of the superoxide anion, and inhibition of the enzyme xanthine oxidase (XO) and lipid peroxidation in human erythrocytes. The extracts presented effect in the DPPH and superoxide anion assay, with values ranging between 40 and 68% and 15-32% at 33 and 50 microg/mL, respectively, inhibited lipid peroxidation in erythrocytes by 19-71% at 500 microg/mL and were inactive toward the XO at 50 microg/mL. Isoorientin, isoscoparin, Swertiajaponin, isoorientin 2' '-O-rhamnoside, orientin, chlorogenic acid, and caffeic acid were isolated and identified by spectroscopic methods. Isoorientin and orientin presented similar activities toward the DPPH (IC(50): 9-10 microM) and inhibited lipid peroxidation by 70% at 100 microg/mL.
    CONCLUSIONS:
    Caffeic and chlorogenic acid were active superoxide anion scavengers with IC(50) values of 68.8 and 54.2 microM, respectively, and a strong effect toward DPPH. Caffeic acid inhibited lipid peroxidation by 85% at 100 microg/mL.
    Oncotarget . 2017 Sep 15;8(56):95530-95541.
    Swertiajaponin inhibits skin pigmentation by dual mechanisms to suppress tyrosinase[Pubmed: 29221146]
    Abstract Many skin-whitening compounds target tyrosinase because it catalyzes two rate-limiting steps in melanin synthesis. Although many tyrosinase inhibitors are currently available for a skin-whitening purpose, undesirable adverse effects are also reported. Thus, numerous efforts have been made to develop safer tyrosinase inhibitors from natural products. In line with this, we tested fifty flavonoids, a group of naturally occurring antioxidants and metal chelators, and screened swertiajaponin as the strongest tyrosinase inhibitor in cell-free experiments. Swertiajaponin did not show cytotoxicity in B16F10, HaCat, and Hs27 cells and exhibited strong anti oxidative activity in experiments using the cell-free system and B16F10 cells. It markedly inhibited αMSH- or UVB-induced melanin accumulation in B16F10 cells and suppressed skin pigmentation in a human skin model. As underlying mechanisms, in silico and Lineweaver-Burk plot analyses exhibited that swertiajaponin may directly bind to and inhibit tyrosinase activity by forming multiple hydrogen bonds and hydrophobic interactions with the binding pocket of tyrosinase. In addition, western blotting results indicated that swertiajaponin inhibited oxidative stress-mediated MAPK/MITF signaling, leading to decrease in tyrosinase protein level. Together, swertiajaponin suppresses melanin accumulation by inhibiting both activity and protein expression levels of tyrosinase. Thus, it would be a novel additive for whitening cosmetics. Keywords: human skin; melanogenesis; pigmentation; swertiajaponin; tyrosinase.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1626 mL 10.8131 mL 21.6263 mL 43.2526 mL 54.0657 mL
    5 mM 0.4325 mL 2.1626 mL 4.3253 mL 8.6505 mL 10.8131 mL
    10 mM 0.2163 mL 1.0813 mL 2.1626 mL 4.3253 mL 5.4066 mL
    50 mM 0.0433 mL 0.2163 mL 0.4325 mL 0.8651 mL 1.0813 mL
    100 mM 0.0216 mL 0.1081 mL 0.2163 mL 0.4325 mL 0.5407 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    光牡荆素II; Lucenin II CFN80138 29428-58-8 C27H30O16 = 610.5 5mg QQ客服:2159513211
    异金雀花素; Isoscoparin CFN90965 20013-23-4 C22H22O11 = 462.40 10mg QQ客服:1148253675
    异金雀花素-2''-Beta-D-吡喃葡萄糖苷; Isoscoparin-2''-Beta-D-glucopyranoside CFN90900 97605-25-9 C28H32O16 = 624.54 5mg QQ客服:1148253675
    4'-O-甲基光牡荆素II; 4'-O-Methyllucenin II (Diosmetin 6,8-di-C-glucoside) CFN95344 98813-28-6 C28H32O16 = 624.6 10mg QQ客服:2159513211
    白杨素 6-C-葡萄糖 8-C-阿拉伯糖苷; Chrysin 6-C-glucoside 8-C-arabinoside CFN92285 185145-34-0 C26H28O13 = 548.5 5mg QQ客服:2159513211
    白杨素 8-C-葡萄糖苷; Chrysin 8-C-glucoside CFN91992 160880-89-7 C21H20O9 = 416.38 5mg QQ客服:3257982914
    白杨素 6-C-阿拉伯糖 8-C-葡萄糖苷; Chrysin 6-C-arabinoside 8-C-glucoside CFN92284 185145-33-9 C26H28O13 = 548.5 5mg QQ客服:1148253675
    异荭草苷; 异荭草素; Luteolin-6-C-glucoside CFN98137 4261-42-1 C21H20O11 = 448.38 20mg QQ客服:1148253675
    日当药黄素,日本当药黄素,日本獐牙菜素; Swertiajaponin CFN90652 6980-25-2 C22H22O11 = 462.4 10mg QQ客服:1148253675
    荭草苷; Orientin CFN98136 28608-75-5 C21H20O11 = 448.38 20mg QQ客服:2932563308

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