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  • 光牡荆素II

    Lucenin II

    光牡荆素II
    产品编号 CFN80138
    CAS编号 29428-58-8
    分子式 = 分子量 C27H30O16 = 610.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The seeds of Alliaria petiolata.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    光牡荆素II CFN80138 29428-58-8 1mg QQ客服:215959384
    光牡荆素II CFN80138 29428-58-8 5mg QQ客服:215959384
    光牡荆素II CFN80138 29428-58-8 10mg QQ客服:215959384
    光牡荆素II CFN80138 29428-58-8 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Donald Danforth Plant Science Center (USA)
  • Auburn University (USA)
  • Medical University of South Carolina (USA)
  • Kyushu University (Japan)
  • Siksha O Anusandhan University (India)
  • Ateneo de Manila University (Philippines)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
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  • Plant Direct.2021, 5(4):e00318.
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  • Pharmaceuticals (Basel). 2021, 14(10):986.
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  • J. of Agricultural Science2015, 1916-9760
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  • ...
  • 生物活性
    Description: Lucenin II has anticonvulsant, antibacterial, anti-inflammatory and antihepatotoxic activity. Lucenin II caused a decrease in the percentage of spore germination, protonemal development and root growth.
    In vitro:
    Iran J Pharm Res . Winter 2017;16(Suppl):46-57.
    Bioactivity-guided Study of Passiflora caerulea L. Leaf Extracts[Pubmed: 29844775]
    Passiflora species were known by their anticonvulsant, anxiolytic and sedative activities. The aim of this study was to investigate the chemical composition of the most active leaf extract of Passiflora caerulea L. grown in Egypt. The ethanolic extract of the leaves exhibited higher activity than aqueous extract as anticonvulsant (63% potency relative to carbamazepine), analgesic (70% potency relative to indomethacin), antioxidant (71% potency relative to vitamin E), anti-inflammatory (90% potency relative to indomethacin) and antipyretic (90% potency relative to paracetamol). Fractions obtained successively from the ethanolic extract were then subjected to the same biological testing demonstrating that the ethyl acetate fraction was the most active in all activities (50, 96, 80, 63 % potency relative to reference standards used in each of the selected activity, respectively) followed by n-butanol then n-hexane and chloroform fractions. Purification of the anticonvulsant sub-fractions obtained by column chromatography of ethyl acetate fraction, led to the isolation of three compounds that were identified by physical and spectroscopic techniques as Lucenin II (1), 4-hydroxycinnamic acid (2) and Chrysin 6-C-β-D-glucoside (3). The amount of Chrysin 6-C-β-D-glucoside was found to be 0.0184 g % w/w of the dried leaves using HPLC method that showed linearity (R2 = 0.9996) over the range 0.015-0.25 mg/mL. C-glycosyl flavones and hydroxycinnamic acid derivatives may thus be the responsible principles for the biological activity of the plant under investigation. Moreover, RAPD technique was performed for the genetic characterization and authentication of the plant, where 106 fragments were recorded after DNA amplification with fifteen primers.
    Phytochemistry . 2003 Apr;62(7):1145-51
    Effects of seven pure flavonoids from mosses on germination and growth of Tortula muralis HEDW (Bryophyta) and Raphanus sativus L (Magnoliophyta)[Pubmed: 12591270]
    Dried mosses (five moss species) were progressively extracted and subjected to a four-step Craig distribution. Seven pure flavonoids were isolated and identified. The flavonoids were the flavones apigenin, apigenin-7-O-triglycoside, lucenin-2, luteolin-7-O-neohesperidoside, saponarine and vitexin; and the biflavonoid bartramiaflavone and they were submitted to biological tests. The tests were performed in vitro on spore germination and protonemal growth of the moss Tortula muralis and on seed germination and root growth of Raphanus sativus. Flavonoids caused a decrease in the percentage of spore germination, protonemal development and root growth. In addition they caused morphological alterations, such as forked tips, swollen apices, rounded cells and early formation of brood cells in the protonemata. Data were discussed in relation to the presence of allelochemicals in mosses.
    Pharm Biol . 2011 Aug;49(8):840-9.
    Secondary metabolites of Centaurea calolepis and evaluation of cnicin for anti-inflammatory, antioxidant, and cytotoxic activities[Pubmed: 21612369]
    Context: Centaurea L. (Astreaceae) species are used as herbal remedies in Turkey. Centaurea calolepis Boiss. is an endemic species of Anatolia that has not been subjected to phytochemical studies except essential oil analysis. Objective: Secondary metabolite determination, isolation and structure elucidation of pure compounds were performed on C. calolepis. Cnicin, which is the main component of several Centaurea species, was tested for its in vitro anti-inflammatory, antioxidant and cytotoxic activities. Materials and methods: Chloroform and methanol extracts of the aerial parts of C. calolepis were subjected to isolation process using column chromatography. The structures of the compounds were characterized by 1D- and 2D-NMR experiments. Thin-layer chromatography and high performance liquid chromatography were used in determination of phenolics. Cnicin was subjected to a panel of cellular assays to test for inhibition of nuclear factor κB (NF-κB), inducible nitric oxide synthase (iNOS), reactive oxygen species and cytotoxicity. Results: Cnicin, lucenin-2, schaftoside and 3-O-feruloylquinic acid were isolated from C. calolepis extracts. Vicenin-2, vitexin, isovitexin, homoorientin, rutin, orientin, luteolin-7-O-glycoside and chlorogenic acid were determined in fractions. Cnicin showed inhibition of NF-κB and inhibition of iNOS activity with IC₅₀ Values of 1.8 and 6.5 μM, respectively. Cytotoxic activity of cnicin was observed toward pig kidney epithelial (LLC-PK₁₁), human malignant melanoma (SK-MEL) and human ductal carcinoma (BT-549) cells with IC₅₀ values of 23.3, 14.0 and 18.3 μM, respectively. Discussion and conclusion: This is the first detailed report of secondary metabolites of C. calolepis. Evaluation of biological activity of cnicin establishes the potential of this compound as an anti-inflammatory and cytotoxic agent.
    Phytochemistry . 1999 Dec;52(8):1479-82
    Antibacterial activity of pure flavonoids isolated from mosses[Pubmed: 10647220]
    Seven pure flavonoids were isolated and identified from five moss species. The flavonoids were the flavones apigenin, apigenin-7-O-triglycoside, lucenin-2, luteolin-7-O-neohesperidoside, saponarine and vitexin; and the biflavonoid bartramiaflavone. Some of these flavonoids were shown to have pronounced antibacterial effects against Enterobacter cloaceae, E. aerogenes and Pseudomonas aeruginosa (minimal bacteriostatic concentration MIC in the range of 4-2048 micrograms/ml). Because of their antibacterial spectrum mainly active against Gram negative bacterial strains, responsible for severe opportunistic infections and resistant to common antibacterial therapy, these flavonoids may be important tools in antibacterial strategies.
    Food Chem . 2014 Apr 15;149:244-252.
    First evidence of C- and O-glycosyl flavone in blood orange (Citrus sinensis (L.) Osbeck) juice and their influence on antioxidant properties[Pubmed: 24295703]
    RP-LC-DAD-ESI-MS-MS separation/identification protocol has been employed for the identification and characterisation of nine C- and O-glycosyl flavonoids in Moro (Citrus sinensis (L.) Osbeck) juice grown in Southern Italy. For the first time we reported the presence of five C-glycosyl flavones (lucenin-2, vicenin-2, stellarin-2, lucenin-2 4'-methyl ether and scoparin), a 3-hydroxy-3-methylglutaryl glycosyl flavonol (3-hydroxy-3-methylglutaryl glycosyl quercetin) and a flavone O-glycosides (chrysoeriol 7-O-neoesperidoside). Moreover, the influence of the identified C- and O-glycosyl flavonoids on the total antioxidant activity of crude juice has been evaluated on the basis of its ability to scavenge DPPH•, OH• and ABTS•+ radicals and to reduce iron.
    Biomol Ther (Seoul) . 2016 Nov 1;24(6):630-637.
    Anti-Inflammatory Properties of Flavone di-C-Glycosides as Active Principles of Camellia Mistletoe, Korthalsella japonica[Pubmed: 27302962]
    The chemical components and biological activity of Camellia mistletoe, Korthalsella japonica (Loranthaceae) are relatively unknown compared to other mistletoe species. Therefore, we investigated the phytochemical properties and biological activity of this parasitic plant to provide essential preliminary scientific evidence to support and encourage its further pharmaceutical research and development. The major plant components were chromatographically isolated using high-performance liquid chromatography and their structures were elucidated using tandem mass spectrometry and nuclear magnetic resonance anlysis. Furthermore, the anti-inflammatory activity of the 70% ethanol extract of K. japonica (KJ) and its isolated components was evaluated using a nitric oxide (NO) assay and western blot analysis for inducible NO synthase (iNOS) and cyclooxygenase (COX)-2. Three flavone di-C-glycosides, lucenin-2, vicenin-2, and stellarin-2 were identified as major components of KJ, for the first time. KJ significantly inhibited NO production and reduced iNOS and COX-2 expression in lipopolysaccharide-stimulated RAW 264.7 cells at 100 μg/ mL while similar activity were observed with isolated flavone C-glycosides. In conclusion, KJ has a simple secondary metabolite profiles including flavone di-C-glycosides as major components and has a strong potential for further research and development as a source of therapeutic anti-inflammatory agents.
    Planta Med . 1992 Dec;58(6):544-548.
    Antihepatotoxic C-glycosylflavones from the leaves of Allophyllus edulis var. edulis and gracilis[Pubmed: 1484895]
    From the leaves of Allophyllus edulis var. edulis and Allophyllus edulis var. gracilis nine C-glycosylflavones have been isolated and identified as schaftoside (8), vicenin-2 (9), lucenin-2 (10), isovitexin 2"-O-rhamnoside (11), cerarvensin 2"-O-rhamnoside (12), vitexin 2"-O-rhamnoside (13), isoorientin 2"-O-rhamnoside (15), orientin 2"-O-rhamnoside (16) and saponarin (17). In addition, gallic acid (2), the phenol C-glycosides bergenin (3) and 11-O-galloylbergenin (4), three flavonol 3-O-rhamnosides and a new C-glycosylflavone identified as mollupentin 2"-O-rhamnoside (14) were obtained from the leaves of Allophyllus edulis var. edulis. Their structures were elucidated on the basis of chemical and spectral data. For the first time the C-glycosylflavones were found to have remarkable anti-hepatotoxic activities against CCl4 and galactosamine cytotoxicity in primary cultured rat hepatocytes. Structure-activity relationships are discussed.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.638 mL 8.19 mL 16.38 mL 32.76 mL 40.95 mL
    5 mM 0.3276 mL 1.638 mL 3.276 mL 6.552 mL 8.19 mL
    10 mM 0.1638 mL 0.819 mL 1.638 mL 3.276 mL 4.095 mL
    50 mM 0.0328 mL 0.1638 mL 0.3276 mL 0.6552 mL 0.819 mL
    100 mM 0.0164 mL 0.0819 mL 0.1638 mL 0.3276 mL 0.4095 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    白杨素 6-C-葡萄糖 8-C-阿拉伯糖苷; Chrysin 6-C-glucoside 8-C-arabinoside CFN92285 185145-34-0 C26H28O13 = 548.5 5mg QQ客服:2056216494
    白杨素 8-C-葡萄糖苷; Chrysin 8-C-glucoside CFN91992 160880-89-7 C21H20O9 = 416.38 5mg QQ客服:1457312923
    白杨素 6-C-阿拉伯糖 8-C-葡萄糖苷; Chrysin 6-C-arabinoside 8-C-glucoside CFN92284 185145-33-9 C26H28O13 = 548.5 5mg QQ客服:215959384
    异荭草苷; 异荭草素; Luteolin-6-C-glucoside CFN98137 4261-42-1 C21H20O11 = 448.38 20mg QQ客服:3257982914
    日当药黄素,日本当药黄素,日本獐牙菜素; Swertiajaponin CFN90652 6980-25-2 C22H22O11 = 462.4 10mg QQ客服:2056216494
    荭草苷; Orientin CFN98136 28608-75-5 C21H20O11 = 448.38 20mg QQ客服:2159513211
    2''-O-p-反式香豆酰基荭草苷; Orientin 2''-O-p-trans-coumarate CFN90653 73815-15-3 C30H26O13 = 594.5 5mg QQ客服:2159513211
    荭草素-2〞-O-β-L-半乳糖苷; 2''-O-Beta-L-Galorientin CFN93096 861691-37-4 C27H30O16 = 610.5 20mg QQ客服:1413575084
    刺苞菊甙; Carlinoside CFN90720 59952-97-5 C26H28O15 = 580.5 5mg QQ客服:1457312923
    异刺苞菊甙; Isocarlinoside CFN95092 83151-90-0 C26H28O15 = 580.5 5mg QQ客服:1457312923

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