| Description: |
Sphondin may have anticonvulsant, anti-inflammatory, and anti-proliferative activities, it may act as a potent inhibitor of NO production under tissue-damaging inflammatory conditions, it also
possesses an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells through suppression of NF-kappaB activity. Sphondin, 8-methoxypsoralen, and khellin have delayed phototoxic effects inAedes aegypti. |
| Targets: |
COX | PGE | IL Receptor | p38MAPK | JNK | p65 | NF-kB | Chk | NO | NOS |
| In vitro: |
| Contact Dermatitis. 1983 Sep;9(5):364-6. | | Phototoxicity from furocoumarins (psoralens) of Heracleum laciniatum in a patient with vitiligo. Action spectrum studies on bergapten, pimpinellin, angelicin and sphondin.[Pubmed: 6627920 ] | Investigations on light reactions in a patient with vitiligo are presented.
METHODS AND RESULTS:
The minimal erythema dose (MED) in the UVB area was approximately 1/3 of that in persons of skin type II. The application of furocoumarins (psoralens) increased light tolerance by 1 MED at 300-310 nm. Action spectrum studies with furocoumarins from Heracleum laciniatum showed the following order of potency: bergapten, pimpinellin, angelicin and Sphondin. The efficacy was highest at 325-350 nm, with maxima at 330-335 nm.
CONCLUSIONS:
Pimpinellin was recently found to be phototoxic, but an action spectrum of Sphondin is reported for the first time. | | J Nat Med. 2014 Jan;68(1):83-94. | | Anti-tumor effects of various furocoumarins isolated from the roots, seeds and fruits of Angelica and Cnidium species under ultraviolet A irradiation.[Pubmed: 23649674] |
METHODS AND RESULTS:
We examined the effects on cell proliferation of 10 methoxyfurocoumarins and 7 dihydrofurocumarins isolated from Umbelliferae medicinal plants, and their mechanisms of action against B16F10 melanoma cells or in melanin-possessing hairless mice implanted with B16F10 melanoma cells, under UVA irradiation. Furocoumarins having a methoxy group, such as bergapten (1), xanthotoxin (2), phellopterin (4), byakangelicin (6), neobyakangelicin (8), isobergapten (9) and Sphondin (10), showed anti-proliferative activity and caused G2/M arrest at concentrations of 0.05-15.0 μM. The 7 dihydrofurocoumarins had no effect. UVA plus 1, 2, 4, 6 and sec-O-acetylbyakagelicin (7), having one methoxy group at the C-5 position and a linear-type conformation, reduced tumor growth and final tumor weight in B16F10-bearing mice at 0.5 or 1.0 mg/kg (intraperitoneal injection). UVA plus 1 and 2 increased Chk1 phosphorylation and decreased cdc2 (Thr 161) phosphorylation in the melanoma cells.
CONCLUSIONS:
The anti-tumor actions of UVA plus furocoumarins having a methoxy group might be due to the arrest of the cell cycle at G2/M through an increase in phospho-Chk1 and reduction in phospho-cdc2. |
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| In vivo: |
| Food Chem., 2008, 107(3):990-3. | | Anticonvulsant activity of furanocoumarins and the essential oil obtained from the fruits of Heracleum crenatifolium.[Reference: WebLink] | The anticonvulsant activity of furanocoumarins, coumarin mixture and the essential oil obtained from the fruits of Heracleum crenatifolium was examined against maximal electroshock (MES)-induced seizures in mice.
METHODS AND RESULTS:
Bergapten showed significant anticonvulsant activity. The furanocoumarins isolated from the fruits of the plant were identified using thin-layer chromatography, melting points and spectroscopic methods (IR, MS, 1H NMR) as isobergapten (1), pimpinellin (2), bergapten (3), isopimpinellin (4), Sphondin (5) and byak-angelicol (6). The essential oil content of the fruits were found as 5.5%.
Twenty-two compounds representing 99.3% of the essential oil obtained from the fruits of H. crenatifolium were determined and the major components were identified as octanol and octyl acetate (3.1% and 88.4% respectively) by GC and GC–MS. |
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