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  • 6-甲氧基当归素

    Sphondin

    6-甲氧基当归素
    产品编号 CFN98763
    CAS编号 483-66-9
    分子式 = 分子量 C12H8O4 = 216.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The fruits of Heracleum sibiricum L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    6-甲氧基当归素 CFN98763 483-66-9 1mg QQ客服:3257982914
    6-甲氧基当归素 CFN98763 483-66-9 5mg QQ客服:3257982914
    6-甲氧基当归素 CFN98763 483-66-9 10mg QQ客服:3257982914
    6-甲氧基当归素 CFN98763 483-66-9 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci.2021, 22(8):4211.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1124:323-330
  • Molecules.2018, 23(9):E2121
  • Molecules.2021, 26(4):816.
  • J Sep Sci.2020, 43(22):4148-4161.
  • Tissue Cell.2022, 75:101728.
  • Allergol Immunopathol (Madr).2022, 1;50(4):23-30.
  • Agronomy2020, 10(10),1489
  • Malaysian J of Fundamental and Applied Sciences 2018, 14(3):368-373
  • Molecules.2020 ,25(16):3697.
  • Food Addit Contam Part A.2021, 38(12):1985-1994.
  • Neurochem Res.2021, s11064-021-03449-0
  • J Med Food.2022, 25(3):272-280.
  • LWT-Food Science and Technology2017, 75:488-496
  • J Microbiol Immunol Infect.2021, S1684-1182(21)00142-0.
  • Molecules.2017, 22(6)
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  • Molecules.2020, 25(23):5609.
  • Plant Foods Hum Nutr.2021, 76(4):472-477.
  • Processes2021, 9(5),831.
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  • Int J Mol Sci.2015, 16(8):18396-411
  • Pak J Pharm Sci.2018, 31:311-315
  • ...
  • 生物活性
    Description: Sphondin may have anticonvulsant, anti-inflammatory, and anti-proliferative activities, it may act as a potent inhibitor of NO production under tissue-damaging inflammatory conditions, it also possesses an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells through suppression of NF-kappaB activity. Sphondin, 8-methoxypsoralen, and khellin have delayed phototoxic effects inAedes aegypti.
    Targets: COX | PGE | IL Receptor | p38MAPK | JNK | p65 | NF-kB | Chk | NO | NOS
    In vitro:
    Contact Dermatitis. 1983 Sep;9(5):364-6.
    Phototoxicity from furocoumarins (psoralens) of Heracleum laciniatum in a patient with vitiligo. Action spectrum studies on bergapten, pimpinellin, angelicin and sphondin.[Pubmed: 6627920 ]
    Investigations on light reactions in a patient with vitiligo are presented.
    METHODS AND RESULTS:
    The minimal erythema dose (MED) in the UVB area was approximately 1/3 of that in persons of skin type II. The application of furocoumarins (psoralens) increased light tolerance by 1 MED at 300-310 nm. Action spectrum studies with furocoumarins from Heracleum laciniatum showed the following order of potency: bergapten, pimpinellin, angelicin and Sphondin. The efficacy was highest at 325-350 nm, with maxima at 330-335 nm.
    CONCLUSIONS:
    Pimpinellin was recently found to be phototoxic, but an action spectrum of Sphondin is reported for the first time.
    J Nat Med. 2014 Jan;68(1):83-94.
    Anti-tumor effects of various furocoumarins isolated from the roots, seeds and fruits of Angelica and Cnidium species under ultraviolet A irradiation.[Pubmed: 23649674]

    METHODS AND RESULTS:
    We examined the effects on cell proliferation of 10 methoxyfurocoumarins and 7 dihydrofurocumarins isolated from Umbelliferae medicinal plants, and their mechanisms of action against B16F10 melanoma cells or in melanin-possessing hairless mice implanted with B16F10 melanoma cells, under UVA irradiation. Furocoumarins having a methoxy group, such as bergapten (1), xanthotoxin (2), phellopterin (4), byakangelicin (6), neobyakangelicin (8), isobergapten (9) and Sphondin (10), showed anti-proliferative activity and caused G2/M arrest at concentrations of 0.05-15.0 μM. The 7 dihydrofurocoumarins had no effect. UVA plus 1, 2, 4, 6 and sec-O-acetylbyakagelicin (7), having one methoxy group at the C-5 position and a linear-type conformation, reduced tumor growth and final tumor weight in B16F10-bearing mice at 0.5 or 1.0 mg/kg (intraperitoneal injection). UVA plus 1 and 2 increased Chk1 phosphorylation and decreased cdc2 (Thr 161) phosphorylation in the melanoma cells.
    CONCLUSIONS:
    The anti-tumor actions of UVA plus furocoumarins having a methoxy group might be due to the arrest of the cell cycle at G2/M through an increase in phospho-Chk1 and reduction in phospho-cdc2.
    In vivo:
    Food Chem., 2008, 107(3):990-3.
    Anticonvulsant activity of furanocoumarins and the essential oil obtained from the fruits of Heracleum crenatifolium.[Reference: WebLink]
    The anticonvulsant activity of furanocoumarins, coumarin mixture and the essential oil obtained from the fruits of Heracleum crenatifolium was examined against maximal electroshock (MES)-induced seizures in mice.
    METHODS AND RESULTS:
    Bergapten showed significant anticonvulsant activity. The furanocoumarins isolated from the fruits of the plant were identified using thin-layer chromatography, melting points and spectroscopic methods (IR, MS, 1H NMR) as isobergapten (1), pimpinellin (2), bergapten (3), isopimpinellin (4), Sphondin (5) and byak-angelicol (6). The essential oil content of the fruits were found as 5.5%. Twenty-two compounds representing 99.3% of the essential oil obtained from the fruits of H. crenatifolium were determined and the major components were identified as octanol and octyl acetate (3.1% and 88.4% respectively) by GC and GC–MS.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.6253 mL 23.1267 mL 46.2535 mL 92.5069 mL 115.6337 mL
    5 mM 0.9251 mL 4.6253 mL 9.2507 mL 18.5014 mL 23.1267 mL
    10 mM 0.4625 mL 2.3127 mL 4.6253 mL 9.2507 mL 11.5634 mL
    50 mM 0.0925 mL 0.4625 mL 0.9251 mL 1.8501 mL 2.3127 mL
    100 mM 0.0463 mL 0.2313 mL 0.4625 mL 0.9251 mL 1.1563 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异补骨脂素; Angelicin CFN98854 523-50-2 C11H6O3 = 186.2 20mg QQ客服:1413575084
    6-甲氧基当归素; Sphondin CFN98763 483-66-9 C12H8O4 = 216.2 5mg QQ客服:1413575084
    异佛手柑内酯; Isobergapten CFN90231 482-48-4 C12H8O4 = 216.19 20mg QQ客服:3257982914
    茴芹内酯; Pimpinellin CFN99402 131-12-4 C13H10O5 = 246.2 20mg QQ客服:2159513211
    Moellendorffilin; Moellendorffilin CFN92638 105099-87-4 C26H20O10 = 492.4 5mg QQ客服:1457312923

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