茴芹内酯

Pimpinellin

	产品编号	CFN99402
	CAS编号	131-12-4
	分子式 = 分子量	C₁₃H₁₀O₅ = 246.2
	产品纯度	>=98%
	物理属性	Yellow powder
	化合物类型	Coumarins
	植物来源	The fruits of Psoralea corylifolia L.
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产品名称	产品编号	CAS编号	包装	QQ客服
茴芹内酯	CFN99402	131-12-4	10mg	QQ客服：3257982914
茴芹内酯	CFN99402	131-12-4	20mg	QQ客服：3257982914
茴芹内酯	CFN99402	131-12-4	50mg	QQ客服：3257982914
茴芹内酯	CFN99402	131-12-4	100mg	QQ客服：3257982914

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Description:

Pimpinellin has phototoxic, it acts as antagonist of proteins with GABA receptor activity. Pimpinellin has anti- inflammatory, and cytotoxic activities. Pimpinellin also has anti-bacterial activity, it shows inhibitory activity against Mycobacterium tuberculosis strain H37Ra , with MICs of 812 uM and IC50s of 389 uM.

Targets:

Antifection

In vitro:

J Ethnopharmacol. 2013 May 2;147(1):232-7.

The Canadian medicinal plant Heracleum maximum contains antimycobacterial diynes and furanocoumarins.[Pubmed: 23501157]

Heracleum maximum is amongst the most commonly used plants by the indigenous peoples of North America. The First Nations of the eastern Canada use infusions of Heracleum maximum roots for the treatment of respiratory ailments including tuberculosis. Previous investigations of extracts derived from the roots of Heracleum maximum have shown it to possess antimycobacterial activity. To isolate and identify antimycobacterial constituents from the roots of Heracleum maximum.
METHODS AND RESULTS:
A methanolic extract of Heracleum maximum roots was subjected to bioassay guided fractionation using the microplate resazurin assay (MRA) to assess inhibitory activity against Mycobacterium tuberculosis strain H37Ra. The antimycobacterial constituents were identified by NMR, MS and polarimetry. The polyacetylene (3R,8S)-falcarindiol and the furanocoumarins bergapten, isobergapten, angelicin, sphondin, pimpinellin, isopimpinellin and 6-isopentenyloxyisobergapten were isolated from the Heracleum maximum root extract. (3R,8S)-Falcarindiol and 6-isopentenyloxyisobergapten exhibited MICs of 24 μM and 167 μM and IC50s of 6 μM and 27 μM against Mycobacterium tuberculosis H37Ra respectively. The remaining furanocoumarins bergapten, isobergapten, angelicin, sphondin, pimpinellin, and isopimpinellin were less active, with MICs of 925, 1850, 2149, 1859, 812 and 1625 μM and IC50s of 125, 344, 350, 351, 389 and 406 μM.
CONCLUSIONS:
(3R,8S)-Falcarindiol, bergapten, isobergapten, angelicin, sphondin, pimpinellin, isopimpinellin and 6-isopentenyloxyisobergapten were identified as the principal constituents responsible for the antimycobacterial activity of the roots of Heracleum maximum. This work supports the ethnopharmacological use of Heracleum maximum by Canadian First Nations and Native American communities as a treatment for infectious diseases, specifically tuberculosis.

In vivo:

J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Apr 1;891-892:102-8.

Simultaneous determination of pimpinellin, isopimpinellin and phellopterin in rat plasma by a validated UPLC-MS/MS and its application to a pharmacokinetic study after administration of Toddalia asiatica extract.[Pubmed: 22418072]

METHODS AND RESULTS:
A rapid and selective ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed for simultaneous determination of three bioactive coumarins of Toddalia asiatica extract including pimpinellin, isopimpinellin and phellopterin in rat plasma for the first time. Phenacetin was used as the internal standard (IS). Plasma samples were extracted by liquid-liquid extraction with methyl tert-butyl ether. The chromatographic separation was carried out on an ACQUITY UPLC™ BEH C₁₈ column with an isocratic mobile phase consisting of methanol-5 mmol/L ammonium acetate (65:35, v/v). The detection was performed on a triple quadrupole tandem mass spectrometer by multiple reaction monitoring (MRM) via electrospray ionization (ESI) source with positive ionization mode. The method was linear for all analytes over investigated range with all correlation coefficients greater than 0.9942. The lower limits of quantification (LLOQ) were 25.0 ng/mL for pimpinellin, 10.0 ng/mL for isopimpinellin and 5.00 ng/mL for phellopterin. The intra- and inter-day precision (RSD%) was within 12% and the accuracy (RE%) ranged from -2.3% to 5.5%.
CONCLUSIONS:
The rapid and sensitive method was fully validated and successfully applied to the pharmacokinetic study of pimpinellin, isopimpinellin and phellopterin in rats following oral administration of Toddalia asiatica extract.

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.0617 mL	20.3087 mL	40.6174 mL	81.2348 mL	101.5435 mL
5 mM	0.8123 mL	4.0617 mL	8.1235 mL	16.247 mL	20.3087 mL
10 mM	0.4062 mL	2.0309 mL	4.0617 mL	8.1235 mL	10.1543 mL
50 mM	0.0812 mL	0.4062 mL	0.8123 mL	1.6247 mL	2.0309 mL
100 mM	0.0406 mL	0.2031 mL	0.4062 mL	0.8123 mL	1.0154 mL

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
异补骨脂素; Angelicin	CFN98854	523-50-2	C₁₁H₆O₃ = 186.2	20mg	QQ客服：2056216494
6-甲氧基当归素; Sphondin	CFN98763	483-66-9	C₁₂H₈O₄ = 216.2	5mg	QQ客服：2056216494
异佛手柑内酯; Isobergapten	CFN90231	482-48-4	C₁₂H₈O₄ = 216.19	20mg	QQ客服：2056216494
茴芹内酯; Pimpinellin	CFN99402	131-12-4	C₁₃H₁₀O₅ = 246.2	20mg	QQ客服：1413575084
Moellendorffilin; Moellendorffilin	CFN92638	105099-87-4	C₂₆H₂₀O₁₀ = 492.4	5mg	QQ客服：3257982914

茴芹内酯

Pimpinellin

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