美丽猪屎豆碱

Spectabiline

	产品编号	CFN00386
	CAS编号	520-55-8
	分子式 = 分子量	C₁₈H₂₅NO₇ = 367.40
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源	The herbs of Crotalaria spectabilis Roth
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
美丽猪屎豆碱	CFN00386	520-55-8	1mg	QQ客服：1457312923
美丽猪屎豆碱	CFN00386	520-55-8	5mg	QQ客服：1457312923
美丽猪屎豆碱	CFN00386	520-55-8	10mg	QQ客服：1457312923
美丽猪屎豆碱	CFN00386	520-55-8	20mg	QQ客服：1457312923

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Chinese University of Hong Kong (China)

China Medical University (Taiwan)

Calcutta University (India)

University of Lodz (Poland)

Helmholtz Zentrum München (Germany)

Chang Gung University (Taiwan)

Korea Food Research Institute(KFRI) (Korea)

Max-Planck-Insitut (Germany)

Griffith University (Australia)

Mahatma Gandhi University (India)

Universiti Sains Malaysia (Malaysia)

Worcester Polytechnic Institute (USA)

University of Wollongong (Australia)

Shanghai Institute of Biochemistry and Cell Biology (China)

More...

Description:

Spectabiline shows tumor-inhibitory properties against one or more test tumors. Spectabiline, monocrotaline, sarracine, lasiocarpine, 7-angelylheliotridine, heliotrine and senecionine have similar antagonistic potencies against responses to both acetylcholine and histamine.

Targets:

AChR | Histamine Receptor

In vitro:

Br J Pharmacol. 1971 Apr;41(4):683-90.

Pyrrolizidine alkaloids: actions on muscarinic receptors in the guinea-pig ileum.[Pubmed: 5579465]

METHODS AND RESULTS:
1. Eleven pyrrolizidine alkaloids have been tested on the isolated guinea-pig ileum preparation.2. Platyphylline, supinine, heleurine and cynaustraline were more potent in antagonizing responses to acetylcholine and carbachol than responses to histamine. Their anticholinergic activity appeared to involve a competitive mechanism.3. Lasiocarpine, monocrotaline, Spectabiline, sarracine, 7-angelylheliotridine, heliotrine and senecionine had similar antagonistic potencies against responses to both acetylcholine and histamine.
CONCLUSIONS:
4. The alkaloids had no appreciable activity as antagonists of acetylcholine in the isolated toad rectus abdominis preparation.5. These results are discussed with respect to interactions of the alkaloids at receptor sites involved in anticholinergic activity at the muscarinic receptor.

J Pharm Sci. 1968 Jul;57(7):1112-7.

Tumor-inhibitory activity of pyrrolizidine alkaloids[Reference: WebLink]

METHODS AND RESULTS:
Eighteen pyrrolizidine alkaloids and several derivatives have been examined for tumor-inhibitory properties. Of these, 10 compounds show significant activity against one or more test tumors. Heliotrine, lasiocarpine, monocrotaline, Spectabiline, and senecionine are highly active against the Walker 256 (intramuscular) system.
CONCLUSIONS:
The activity pattern is consistent with the tumor-inhibitory action being associated with the allylic ester function which imparts alkylating ability and is also responsible for hepatotoxicity.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Crosemperine; Crosemperine	CFN00362	30785-56-9	C₁₉H₂₉NO₆ = 367.44	5mg	QQ客服：215959384
Crotalarine; Crotalarine	CFN00364	53937-97-6	C₁₈H₂₇NO₆ = 353.41	5mg	QQ客服：3257982914
芝麻菜叶千里光碱; Erucifoline	CFN00369	40158-95-0	C₁₈H₂₃NO₆ = 349.38	5mg	QQ客服：215959384
芝麻菜叶千里光碱N-氧化物; Erucifolin N-oxide	CFN00453	123864-94-8	C₁₈H₂₃NO₇ = 365.4	5mg	QQ客服：3257982914
夾可鹼; Jacobine	CFN00375	6870-67-3	C₁₈H₂₅NO₆ = 351.40	5mg	QQ客服：1413575084
千里光碱 N-氧化物; Jacobine N-oxide	CFN00461	38710-25-7	C₁₈H₂₅NO₇ = 367.4	5mg	QQ客服：2056216494
马杜拉猪屎豆碱; Madurensine	CFN00380	26126-78-3	C₁₈H₂₅NO₆ = 351.40	5mg	QQ客服：215959384
Spiranine; Spiranine	CFN00382	77156-23-1	C₂₃H₃₅NO₉ = 469.53	5mg	QQ客服：3257982914
野百合碱N-氧化物; Monocrotaline N-oxide	CFN00385	35337-98-5	C₁₆H₂₃NO₇ = 341.36	5mg	QQ客服：1457312923
美丽猪屎豆碱; Spectabiline	CFN00386	520-55-8	C₁₈H₂₅NO₇ = 367.40	5mg	QQ客服：3257982914

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.7218 mL	13.6091 mL	27.2183 mL	54.4366 mL	68.0457 mL
5 mM	0.5444 mL	2.7218 mL	5.4437 mL	10.8873 mL	13.6091 mL
10 mM	0.2722 mL	1.3609 mL	2.7218 mL	5.4437 mL	6.8046 mL
50 mM	0.0544 mL	0.2722 mL	0.5444 mL	1.0887 mL	1.3609 mL
100 mM	0.0272 mL	0.1361 mL	0.2722 mL	0.5444 mL	0.6805 mL