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    Jacobine

    夾可鹼
    		产品编号 CFN00375
    CAS编号 6870-67-3
    分子式 = 分子量 C18H25NO6 = 351.40
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The herbs of Senecio scandens
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    夾可鹼 CFN00375 6870-67-3 1mg QQ客服：2056216494
    夾可鹼 CFN00375 6870-67-3 5mg QQ客服：2056216494
    夾可鹼 CFN00375 6870-67-3 10mg QQ客服：2056216494
    夾可鹼 CFN00375 6870-67-3 20mg QQ客服：2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • University of Leipzig (Germany)
  • University of South Australia (Australia)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • Sri Ramachandra University (India)
  • University of Bonn (Germany)
  • Medical University of Gdansk (Poland)
  • Chinese University of Hong Kong (China)
  • Semmelweis Unicersity (Hungary)
  • Center for protein Engineering (CIP) (Belgium)
  • Universidad Veracuzana (Mexico)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • Harvard University (USA)
  • University of Brasilia (Brazil)
  • University of Stirling (United Kingdom)
  • More...
    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Industrial Crops and Products2022, 188:115596.
  • Oncol Rep.2016, 35(3):1356-64
  • Biomed Pharmacother.2023, 162:114617.
  • Int J Mol Sci.2022, 23(23):15213.
  • RSC Advances2017, 86
  • Natural Product Communications2022, 7(3):1-7.
  • Int. J. Mol. Sci.2022, 23(8), 4130.
  • Antioxidants (Basel).2020, 9(2): E119
  • Food and Bioprocess Technology2017, 10(6):1074-1092
  • Cosmetics2021, 8(3),91.
  • Food Chem X.2024, 21:101208.
  • J Nat Prod.2015, 78(6):1339-4
  • Neurotox Res.2022, 40(6):1937-1947.
  • Asian J Beauty Cosmetol2020, 18(3): 265-272.
  • Phytochemistry Letters2015, 243-247
  • Phytomedicine.2020, 79, 153351
  • Cells. 2023, 12(15):1934.
  • Biomedicines.2020, 8(11):486.
  • J Pharm Anal.2016, 6(6):363-373
  • Molecules.2023, 28(16):6025.
  • Processes 2021, 9(5),894.
  • J Food Compos Anal2017, 62:197-204
  • Data Science for Genomics2023, 107-128.
  • ...
    • 生物活性
    Description: Jacobine induces significant dose-dependent DNA-DNA interstrand cross-linking over the entire range of doses. It was catalyzed by guinea pig hepatic glutathione-S-transferase enzymes in in vitro experiments.
    In vitro:
    Biochemical and Biophysical Research Communications,1994,198(2):516–522.
    Glutathione Conjugation with the Pyrrolizidine Alkaloid, Jacobine[Reference: WebLink]

    METHODS AND RESULTS:
    The reaction of glutathione with the epoxide containing pyrrolizidine alkaloid, jacobine, was catalyzed by guinea pig hepatic glutathione-S-transferase enzymes in in vitro experiments; the rate of the reaction in the presence of rat hepatic glutathione-S-transferases did not differ from the non-enzymatic rate. Using ion-pairing liquid chromatography we were able to isolate the conjugate and obtain a daughter ion spectrum using Fast Atom Bombardment Mass Spectrometry together with Collisionally Activated Dissociation/Mass Analyzed Kinetic Energy experiments.
    In vivo:
    Toxicology Letters.1986,32(3):275-281.
    Genotoxicity of the pyrrolizidine alkaloid jacobine in rats[Reference: WebLink]
    Jacobine (JAC) is a pyrolizidine alkaloid (PA) exhibiting adverse hepatic effects similar to those induced by another PA, monocrotaline (MCT). The in vitro reaction kinetics of JAC, however, have been reported to differ quantitively from those of MCT.
    METHODS AND RESULTS:
    We report results of experiments to detect and characterize hepatic DNA damage resulting from in vivo administration of JAC (5–60 mg/kg i.p.) to male Sprague-Dawley rats. Hepatic nuclei were isolated and served as the source of DNA in these experiments. Alkaline elution was employed to characterize the type(s) of DNA damage induced. At 4 h post administration, JAC induced significant dose-dependent DNA-DNA interstrand cross-linking over the entire range of doses. Significant DNA-protein cross-linking was also induced by doses of 15–60 mg/kg. No DNA single-strand breaks were detected. Previous studies in this laboratory have shown MCT to induce these same types of lesions.
    CONCLUSIONS:
    Results from these experiments demonstrate that despite a reported difference in in vitro reaction kinetics, these compounds induce a similar spectrum of DNA damage in the target organ of a susceptible species, where the adverse effects induced are also similar, such similarities are consistent with the involvement of DNA damage in the adverse hepatic effects of PAs.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8458 mL 14.2288 mL 28.4576 mL 56.9152 mL 71.144 mL
    5 mM 0.5692 mL 2.8458 mL 5.6915 mL 11.383 mL 14.2288 mL
    10 mM 0.2846 mL 1.4229 mL 2.8458 mL 5.6915 mL 7.1144 mL
    50 mM 0.0569 mL 0.2846 mL 0.5692 mL 1.1383 mL 1.4229 mL
    100 mM 0.0285 mL 0.1423 mL 0.2846 mL 0.5692 mL 0.7114 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Seneciocannabine; Seneciocannabine CFN00416 81855-31-4 C18H23NO7 = 365.38 5mg QQ客服：1457312923
    Swazine; Swazine CFN00431 38763-74-5 C18H23NO6 = 349.38 5mg QQ客服：2056216494
    抗菌素 PF 1018; Antibiotic PF 1018 CFN00437 131256-42-3 C28H35NO3 = 433.59 5mg QQ客服：2159513211
    Crosemperine; Crosemperine CFN00362 30785-56-9 C19H29NO6 = 367.44 5mg QQ客服：1457312923
    Crotalarine; Crotalarine CFN00364 53937-97-6 C18H27NO6 = 353.41 5mg QQ客服：1413575084
    芝麻菜叶千里光碱; Erucifoline CFN00369 40158-95-0 C18H23NO6 = 349.38 5mg QQ客服：3257982914
    芝麻菜叶千里光碱N-氧化物; Erucifolin N-oxide CFN00453 123864-94-8 C18H23NO7 = 365.4 5mg QQ客服：215959384
    夾可鹼; Jacobine CFN00375 6870-67-3 C18H25NO6 = 351.40 5mg QQ客服：1413575084
    千里光碱 N-氧化物; Jacobine N-oxide CFN00461 38710-25-7 C18H25NO7 = 367.4 5mg QQ客服：2159513211
    马杜拉猪屎豆碱; Madurensine CFN00380 26126-78-3 C18H25NO6 = 351.40 5mg QQ客服：2159513211

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