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  • (-)-鹰爪豆碱

    (-)-Sparteine

    (-)-鹰爪豆碱
    产品编号 CFN90180
    CAS编号 24915-04-6
    分子式 = 分子量 C15H26N2 = 234.38
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The herbs of Parochetus communis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    (-)-鹰爪豆碱 CFN90180 24915-04-6 1mg QQ客服:1457312923
    (-)-鹰爪豆碱 CFN90180 24915-04-6 5mg QQ客服:1457312923
    (-)-鹰爪豆碱 CFN90180 24915-04-6 10mg QQ客服:1457312923
    (-)-鹰爪豆碱 CFN90180 24915-04-6 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • Florida A&M University (USA)
  • National Research Council of Canada (Canada)
  • Korea Food Research Institute(KFRI) (Korea)
  • FORTH-IMBB (Greece)
  • Ain Shams University (Egypt)
  • Georgia Institute of Technology (USA)
  • John Innes Centre (United Kingdom)
  • Universidad Industrial de Santander (Colombia)
  • University of Toronto (Canada)
  • Hamdard University (India)
  • National Cancer Center Research Institute (Japan)
  • Texas A&M University (USA)
  • Instituto Politécnico de Bragan?a (Portugal)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int Immunopharmacol.2023, 123:110572.
  • Enzyme Microb Technol.2019, 122:64-73
  • Evid Based Complement Alternat Med.2022, 2022:1307173.
  • Int J Mol Sci.2021, 22(21):11836.
  • Journal of Ginseng Research2021, 25 November
  • Int Immunopharmacol.2023, 7:127:111322.
  • Anal Bioanal Chem. 2016, 408(15)
  • QASCF2022, 14(4).
  • LWT2020, 126:109313
  • The Japan Society for Analytical Chemistry2017, 613-617
  • Int J Mol Sci.2020, 21(19):7209.
  • Current Pharmaceutical Analysis2017, 13(5)
  • Psychopharmacology (Berl).2020, 10.1007
  • Neurochem Res.2021, s11064-021-03449-0
  • J Food Compos Anal2017, 62:197-204
  • Phytomedicine.2022, 102:154183.
  • J Pharmaceut Biomed2020, 178:112894
  • Foods.2021, 10(12):2929.
  • Foods.2021, 10(11):2627.
  • Environ Toxicol.2020, doi: 10.1002
  • Food Chem.2021, 377:131976.
  • J Int Med Res.2021, 49(7):3000605211032849.
  • Journal of Food Quality2022, P:13, 6256310.
  • ...
  • 生物活性
    Description: Sparteine is a class 1a antiarrhythmic agent, a sodium channel blocker. The deficient debrisoquine hydroxylation of Sparteine is due to the absence of P-450IID1 protein in the livers of poor metabolizers.
    Targets: P450 (e.g. CYP17)
    In vitro:
    J Org Chem. 2015 Apr 3;80(7):3368-86.
    Highly enantioselective (-)-sparteine-mediated lateral metalation-functionalization of remote silyl protected ortho-ethyl N,N-dialkyl aryl O-carbamates.[Pubmed: 25521308 ]

    METHODS AND RESULTS:
    We report the enantioselective, lateral deprotonation of ortho-protected or functionalized tertiary N,N-dialkyl aryl O-carbamates 5-7 (Scheme 2 ) and meta-protected carbamates 14, 15, and 20 (Schemes 5 and 7 ) by s-BuLi/(-)-Sparteine and subsequent quench with a variety of electrophiles to give products 11-13 and 16, 17, and 21 in yields up to 96% and enantiomeric ratios up to 99:1. The influence of organolithium reagents, ratio of organolithium/(-)-Sparteine pair versus N,N-dialkyl aryl O-carbamate starting materials, temperature, solvents, electrophiles, substituents located ortho or meta to the O-carbamate moiety, and O-carbamate N-substituents was investigated. The identical absolute configuration of the stereogenic center of the major enantiomers of the products, as established by single-crystal X-ray analysis for substrates (S)-11c, (S)-19, and (S)-21a, provides evidence for a consistent stereochemical course in the enantioselective deprotonation. Mechanistic investigations, including an estimate of the configurational stability of the benzyllithium species 9 (starting from 12e; Scheme 8 ) and 23 (starting from 17e; Scheme 9 ), both derived by tin-lithium exchange, and 24 (starting from 20; Scheme 9 ) are reported.
    CONCLUSIONS:
    The experimental results, together with semiempirical molecular orbital calculations (PM3/SMD), are consistent with a process in which enantioinduction occurs in the deprotonation step (Scheme 11 ).
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.2666 mL 21.3329 mL 42.6658 mL 85.3315 mL 106.6644 mL
    5 mM 0.8533 mL 4.2666 mL 8.5332 mL 17.0663 mL 21.3329 mL
    10 mM 0.4267 mL 2.1333 mL 4.2666 mL 8.5332 mL 10.6664 mL
    50 mM 0.0853 mL 0.4267 mL 0.8533 mL 1.7066 mL 2.1333 mL
    100 mM 0.0427 mL 0.2133 mL 0.4267 mL 0.8533 mL 1.0666 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    N-甲基野靛碱; N-Methylcytisine CFN99776 486-86-2 C12H16N2O = 204.27 20mg QQ客服:1457312923
    N-甲酰金雀花碱; N-Formylcytisine CFN91819 53007-06-0 C12H14N2O2 = 218.3 5mg QQ客服:2056216494
    乙酰金雀花碱; Acetylcytisine CFN91701 6018-52-6 C13H16N2O2 = 232.3 5mg QQ客服:2159513211
    黄华碱; Thermopsine CFN90461 486-90-8 C15H20N2O = 244.33 10mg QQ客服:215959384
    安纳基林; Anagyrine CFN92067 486-89-5 C15H20N2O = 244.3 5mg QQ客服:2056216494
    赝靛叶碱; Baptifoline CFN91986 732-50-3 C15H20N2O2 = 260.33 5mg QQ客服:2056216494
    alpha-异羽扇豆鹼; alpha-Isolupanine CFN91985 486-87-3 C15H24N2O = 248.36 5mg QQ客服:3257982914
    羽扇豆鹼; Lupanine CFN98924 550-90-3 C15H24N2O = 248.4 5mg QQ客服:1413575084
    13-羟基羽扇豆鹼; 13-Hydroxylupanine CFN92232 15358-48-2 C15H24N2O2 = 264.4 5mg QQ客服:2159513211
    Angustifoline; Angustifoline CFN92233 550-43-6 C14H22N2O = 234.3 5mg QQ客服:1413575084

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