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  • N-甲基野靛碱

    N-Methylcytisine

    N-甲基野靛碱
    产品编号 CFN99776
    CAS编号 486-86-2
    分子式 = 分子量 C12H16N2O = 204.27
    产品纯度 >=98%
    物理属性 White cryst.
    化合物类型 Alkaloids
    植物来源 The roots of Sophora flavescens
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    N-甲基野靛碱 CFN99776 486-86-2 10mg QQ客服:1457312923
    N-甲基野靛碱 CFN99776 486-86-2 20mg QQ客服:1457312923
    N-甲基野靛碱 CFN99776 486-86-2 50mg QQ客服:1457312923
    N-甲基野靛碱 CFN99776 486-86-2 100mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Institute of Chinese Materia Medica (China)
  • Max Rubner-Institut (MRI) (Germany)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • University of Medicine and Pharmacy (Romania)
  • Chang Gung University (Taiwan)
  • National Chung Hsing University (Taiwan)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Applied Biological Chemistry2021, 64(2):185-192
  • Int J Mol Sci.2021, 22(19):10405.
  • Molecules.2017, 22(3)
  • Chem Biodivers.2023, 20(10):e202300741.
  • Molecules.2016, 21(6)
  • Industrial Crops and Products2020, 146:112186
  • Dicle Tip Dergisi2020, 47(2),423-430.
  • Nutrients.2023, 15(6):1417.
  • Sci Rep.2018, 8:15059
  • Natural Product Communications2020, doi: 10.1177.
  • Biocell2023, 47(8):1793-1802
  • Nat Prod Communications2018, 10.1177
  • Evid Based Complement Alternat Med.2021, 2021:5319584.
  • Int J Nanomedicine.2022, 17:6513-6525.
  • J of Health Science and Alternative Medicine2019, 1(1)
  • Int J Mol Sci.2021, 22(12):6466.
  • Food Bioscience2023, 56:103311.
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  • BMC Complement Altern Med.2014, 14:242
  • Front Pharmacol.2022, 13:806869.
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  • European Journal of Integrative Medicine2018, 20:165-172
  • Mol Divers.2022, s11030-022-10586-3.
  • ...
  • 生物活性
    Description: N-Methylcytisine's nicotinic receptors have high affinity (KD = 50 nM)to nAChR from squid optical ganglia, N-methylcytisine is a selective ligand of nicotinic receptors of acetylcholine in the central nervous system. (−)-N-methylcytisine and (−)-anagyrine have nematicidal activity against pine wood nematodes.
    Targets: AChR
    In vitro:
    Biull Eksp Biol Med. 1989 Jun;107(6):706-9.
    [Effect of nucleotides on N-methylcytisine and dimethyltubocurarine binding by the nicotinic acetylcholine receptors of the optic ganglia in the squid B. magister].[Pubmed: 2790167]
    The effect of nucleosides mono-, di-, and triphosphates on binding of 3H-N-methylcytisine and 14C-tubocurarine to nAChR from squid optical ganglia were investigated.
    METHODS AND RESULTS:
    It was found, that ATP and GTP potentiate the specific binding of 3H-N-methylcytisine and inhibit the one of 14C-tubocurarine. While conducting the photoaffinity modification of nACHR by 3H-azidomethylcytisine in the presence of ATP the increase of specific incorporation of label was observed in comparison with control. Molecular weight of labeled receptor complex and subunit, carrying the binding site was the same as the original.
    Biull Eksp Biol Med. 1987 Dec;104(12):690-2.
    [N-methylcytisine--a selective ligand of nicotinic receptors of acetylcholine in the CNS].[Pubmed: 3689962]
    The ability of cytisine and its N-methyl derivatives to bind to nicotinic acetylcholine receptors (nAChR) from different tissues was studied.
    METHODS AND RESULTS:
    Cytisine and N-methylcytisine have high affinity (KD = 50 nM) to nAChR from squid optical ganglia. N,N-dimethylcytisine did not show high affinity to this receptor. In the case of nAChR from T. marmorata, cytisine was the only effective inhibitor of 14C-tubocurarine specific binding (Ki = 700 nM). N-methyl- and N,N-dimethylcytisine did not displace 14C-tubocurarine at a concentration of 0.1 mM.
    CONCLUSIONS:
    The results obtained indicate that there are some differences in the structure of nAChR binding sites from squid and T. marmorata optical ganglia.
    Agric. Biol. Chem., 1989, 53(8):2287-8.
    Nematicidal Activities of ( – )--Methylcytisine and ( – )-Anagyrine from Sophora flavescens against Pine Wood Nematodes[Reference: WebLink]
    Although the effects of ( - )-N-methyleytisine (1) on the motility of Angiostrongylus cantonensis, Dipylidium caninum and Fasciola hepatica have already been investigated by Te r ada e t al.,5) the activities of ( -)-N-Methylcytisine (1) and ( -)-anagyrine (2) against pl ant parasitic nematodes have never been reported.
    METHODS AND RESULTS:
    The inhibitory effects of ( -)-N-methyleytisine and ( -)-anagyrine, together with ( -)-cytisine and ( - )-nicotine (Sigma Chern. Co.), on the propaga t ion of the pine wood nematode, Bursaphelenchus xylophilus, were examined by the sameprocedure as that described by Kawazu e t aU) As shown in Tables I and I I , the nematicidal activity of ( -) -Nmethylcytisine was about twice that of ( - )-anagyrine, but a half that of ( - )-cytisine and ( - )-nicotine.
    CONCLUSIONS:
    This result of ( - )-N-Methylcytisine and ( -)-anagyrine being the primary nematicidal constituents among various alkaloids contained in the root of S. jiavescens2 • 6 ) suggests that the cytisine-type structure common to both alkaloids (1 and 2) is favorable to show the nematicidal activity.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.8955 mL 24.4774 mL 48.9548 mL 97.9096 mL 122.387 mL
    5 mM 0.9791 mL 4.8955 mL 9.791 mL 19.5819 mL 24.4774 mL
    10 mM 0.4895 mL 2.4477 mL 4.8955 mL 9.791 mL 12.2387 mL
    50 mM 0.0979 mL 0.4895 mL 0.9791 mL 1.9582 mL 2.4477 mL
    100 mM 0.049 mL 0.2448 mL 0.4895 mL 0.9791 mL 1.2239 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    硫酸金雀花碱; Sparteine sulfate pentahydrate CFN99777 299-39-8 C15H28N2O4S = 332.46 20mg QQ客服:2159513211
    金雀花碱; Cytisine CFN99513 485-35-8 C11H14N2O = 190.24 20mg QQ客服:2056216494
    N-甲基野靛碱; N-Methylcytisine CFN99776 486-86-2 C12H16N2O = 204.27 20mg QQ客服:2159513211
    N-甲酰金雀花碱; N-Formylcytisine CFN91819 53007-06-0 C12H14N2O2 = 218.3 5mg QQ客服:3257982914
    乙酰金雀花碱; Acetylcytisine CFN91701 6018-52-6 C13H16N2O2 = 232.3 5mg QQ客服:2056216494
    黄华碱; Thermopsine CFN90461 486-90-8 C15H20N2O = 244.33 10mg QQ客服:2056216494
    安纳基林; Anagyrine CFN92067 486-89-5 C15H20N2O = 244.3 5mg QQ客服:1457312923
    赝靛叶碱; Baptifoline CFN91986 732-50-3 C15H20N2O2 = 260.33 5mg QQ客服:2056216494
    alpha-异羽扇豆鹼; alpha-Isolupanine CFN91985 486-87-3 C15H24N2O = 248.36 5mg QQ客服:2159513211
    羽扇豆鹼; Lupanine CFN98924 550-90-3 C15H24N2O = 248.4 5mg QQ客服:1457312923

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