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  • 大豆皂苷 Ba

    Soyasaponin Ba

    大豆皂苷 Ba
    产品编号 CFN90722
    CAS编号 114590-20-4
    分子式 = 分子量 C48H78O19 = 959.1
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The seeds of Glycine max
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    大豆皂苷 Ba CFN90722 114590-20-4 10mg QQ客服:2159513211
    大豆皂苷 Ba CFN90722 114590-20-4 20mg QQ客服:2159513211
    大豆皂苷 Ba CFN90722 114590-20-4 50mg QQ客服:2159513211
    大豆皂苷 Ba CFN90722 114590-20-4 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Kyushu University (Japan)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • International Food Research Journal2018, 25(6):2560-2571
  • Phytomedicine2022, 104:154318
  • Molecules2022, 27(9):2992.
  • Analytical Methods2018, 10(27)
  • Molecules.2021, 26(4):1084.
  • J Ethnopharmacol.2019, 244:112074
  • Phytomedicine.2022, 110:154597.
  • Food Chem.2020, 327:126992.
  • Evid Based Complement Alternat Med.2017, 2017:7383104
  • Phytomedicine.2015, 22(4):498-503
  • Anal Sci.2019, 35(12):1317-1325
  • J Clin Med.2022, 11(13):3662.
  • Molecules.2021, 26(4):817.
  • J Biotechnol.2020, 318:10-19.
  • Front Pharmacol.2017, 8:205
  • APMIS.2019, 127(10):688-695
  • Journal of Food Quality2022, P:13, 6256310.
  • Front Pharmacol.2021, 12:744624.
  • Biochem Pharmacol. 2020, 177:114014.
  • Molecules.2019, 24(16):E3003
  • Nutr Cancer.2022, 1-13.
  • Journal of Molecular Liquids2021, 334:116014.
  • Journal of Third Military Medical University2018, 40(12):1073-1078
  • ...
  • 生物活性
    Description: Soyasaponins(Aa, Ab, Af, Ba, Bb, and Bb') together with their derivatives may represent viable candidates for effective vaccine adjuvants due to their higher and lower or non-haemolytic effects.Soyasaponins Ab and Bb prevent scopolamine-induced memory impairment in mice without the inhibition of acetylcholinesterase.
    Targets: cAMP
    In vitro:
    J Enzyme Inhib Med Chem . 2019 Dec;34(1):350-360.
    Soyasaponins from Zolfino bean as aldose reductase differential inhibitors[Pubmed: 30734590]
    Abstract Seven triterpenoid saponins were identified in methanolic extracts of seeds of the Zolfino bean landrace (Phaseolus vulgaris L.) by HPLC fractionation, revealing their ability to inhibit highly purified human recombinant aldose reductase (hAKR1B1). Six of these compounds were associated by MS analysis with the following saponins already reported in different Phaseolus vulgaris varieties: soyasaponin Ba (V), soyasaponin Bb, soyasaponin Bd (sandosaponin A), soyasaponin αg, 3-O-[R-l-rhamnopyranosyl(1 → 2)-α-d-glucopyranosyl(1 → 2)-α-d-glucuronopyranosyl]olean-12-en-22-oxo-3α,-24-diol, and soyasaponin βg. The inhibitory activity of the collected fractions containing the above compounds was tested for hAKR1B1-dependent reduction of both l-idose and 4-hydroxynonenal, revealing that some are able to differentially inhibit the enzyme. The present work also highlights the difficulties in the search for aldose reductase differential inhibitors (ARDIs) in mixtures due to the masking effect on ARDIs exerted by the presence of conventional aldose reductase inhibitors. The possibility of differential inhibition generated by a different inhibitory model of action of molecules on different substrates undergoing transformation is also discussed. Keywords: Saponins; Zolfino bean; aldose reductase; differential inhibitors.
    In vivo:
    J.Agr.Food Chem., 2014, 62(9):2062-8.
    Soyasaponins Ab and Bb prevent scopolamine-induced memory impairment in mice without the inhibition of acetylcholinesterase.[Pubmed: 24450802 ]
    Soy (Glycine max, family Leguminosae), which contains isoflavones and saponins as main constituents, is known to exhibit memory-enhancing effects.
    METHODS AND RESULTS:
    Therefore, to investigate the role of soyasaponins in memory impairments, we isolated soyasaponin Ab (SA) and soyasaponin Bb (SB) from soybean and measured their protective effects against scopolamine-induced memory impairment in mice. SA and SB significantly prevented scopolamine-induced memory impairment in passive avoidance and Y-maze tasks. Compared to SA, SB rescued memory impairment more potently. Treatment with SB (10 mg/kg, p.o.) protected memory impairment in passive avoidance and Y-maze tasks to 97% (F = 68.10, P < 0.05) and 78% (F = 35.57, P < 0.05) of untreated normal control level, respectively. SA and SB (10 mg/kg) also rescued scopolamine-induced memory impairment in Morris water maze task (F = 14.51, P < 0.05). In addition, soyasaponins preserved brain-derived neurotrophic factor (BNDF) expression (F = 33.69, P < 0.05) and cAMP response element-binding (CREB) protein phosphorylation (F = 91.62, P < 0.05) in the hippocampus of scopolamine-treated mice. However, SA and SB did not inhibit acetylcholinesterase in vitro and ex vivo.
    CONCLUSIONS:
    On the basis of these findings, we suggest that soybean, particularly soyasaponins, may protect memory impairment by increasing BDNF expression and CREB phosphorylation.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.0426 mL 5.2132 mL 10.4264 mL 20.8529 mL 26.0661 mL
    5 mM 0.2085 mL 1.0426 mL 2.0853 mL 4.1706 mL 5.2132 mL
    10 mM 0.1043 mL 0.5213 mL 1.0426 mL 2.0853 mL 2.6066 mL
    50 mM 0.0209 mL 0.1043 mL 0.2085 mL 0.4171 mL 0.5213 mL
    100 mM 0.0104 mL 0.0521 mL 0.1043 mL 0.2085 mL 0.2607 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Pedunsaponin A; Pedunsaponin A CFN80329 250613-27-5 C42H66O15 = 811.0 5mg QQ客服:3257982914
    大豆皂苷Be甲酯; Soyasaponin Be methyl Ester CFN90777 N/A C49H78O18 = 955.2 5mg QQ客服:215959384
    大豆皂苷Bd; Soyasaponin Bd CFN90775 N/A C48H76O19 = 957.1 5mg QQ客服:3257982914
    大豆皂苷IV; Soyasaponin IV CFN93251 108906-97-4 C41H66O13 = 767.0 5mg QQ客服:1457312923
    大豆皂苷 III; Soyasaponin III CFN91596 55304-02-4 C42H68O14 = 796.99 5mg QQ客服:215959384
    大豆皂苷II; Soyasaponin II CFN93159 55319-36-3 C47H76O17 = 913.1 5mg QQ客服:2159513211
    大豆皂苷Bb; Soyasaponin Bb CFN90456 51330-27-9 C48H78O18 = 943.12 20mg QQ客服:1413575084
    大豆皂苷 Ba; Soyasaponin Ba CFN90722 114590-20-4 C48H78O19 = 959.1 20mg QQ客服:1457312923
    大豆皂苷Aa; Soyasaponin Aa CFN90455 117230-33-8 C64H100O31 = 1365.46 5mg QQ客服:1457312923
    大豆皂苷Ab; Soyasaponin Ab CFN90773 118194-13-1 C67H104O33 = 1437.6 5mg QQ客服:1413575084

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