鱼腥草素纳

Sodium houttuyfonate

	产品编号	CFN90975
	CAS编号	1847-58-1
	分子式 = 分子量	C₁₄H₂₇NaO₅S = 330.4
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Miscellaneous
	植物来源	The herbs of Houttuynia cordata Thunb.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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鱼腥草素纳	CFN90975	1847-58-1	10mg	QQ客服：1413575084
鱼腥草素纳	CFN90975	1847-58-1	20mg	QQ客服：1413575084
鱼腥草素纳	CFN90975	1847-58-1	50mg	QQ客服：1413575084
鱼腥草素纳	CFN90975	1847-58-1	100mg	QQ客服：1413575084

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Tohoku University (Japan)

The University of Newcastle (Australia)

Worcester Polytechnic Institute (USA)

University of Mysore (India)

Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)

Universiti Putra Malaysia(UPM) (Malaysia)

Weizmann Institute of Science (Israel)

National Cancer Center Research Institute (Japan)

Lodz University of Technology (Poland)

VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)

University of Pretoria (South Africa)

University of Vigo (Spain)

Universidad de La Salle (Mexico)

Universidad Veracuzana (Mexico)

More...

Description:

Sodium houttuyfonate is anti-pseudomonas agents, inhibits virulence related motility of Pseudomonas aeruginosa.It also inhibits biofilm formation and alginate biosynthesis-associated gene expression in a clinical strain of Pseudomonas aeruginosa in vitro. Sodium houttuyfonate has anti-inflammatory activity, inhibits inflammation by blocking the MAPKs/NF-κB signaling pathways in bovine endometrial epithelial cells.

Targets:

NF-kB | IL Receptor | p65 | ERK | p38MAPK | JNK

In vitro:

Exp Ther Med. 2015 Aug;10(2):753-758.

Sodium houttuyfonate inhibits biofilm formation and alginate biosynthesis-associated gene expression in a clinical strain of Pseudomonas aeruginosa in vitro.[Pubmed: 26622388]

The increasing multidrug resistance of Pseudomonas aeruginosa has become a serious public-health problem.
METHODS AND RESULTS:
In the present study, the inhibitory activities of sodium houttuyfonate (SH) against biofilm formation and alginate production in a clinical strain of P.aeruginosa (AH16) were investigated in vitro using crystal violet dying and standard curve methods, respectively. The cellular morphology of P. aeruginosa treated with SH was observed using a scanning electron microscope. Furthermore, reverse transcription-quantitative polymerase chain reaction was used to identify differences in the expression levels of genes associated with alginate biosynthesis as a result of the SH treatment. The results indicated that SH significantly inhibited biofilm formation, and decreased the levels of the primary biofilm constituent, alginate, in P. aeruginosa AH16 at various stages of biofilm development. In addition, scanning electron microscopy observations demonstrated that SH markedly altered the cellular morphology and biofilm structure of P. aeruginosa. Furthermore, the results from the reverse transcription-quantitative polymerase chain reaction analysis indicated that SH inhibited biofilm formation by mitigating the expression of the algD and algR genes, which are associated with alginate biosynthesis.
CONCLUSIONS:
Therefore, the present study has provided novel insights into the potent effects and underlying mechanisms of SH-induced inhibition of biofilm formation in a clinical strain of P. aeruginosa.

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.0266 mL	15.1332 mL	30.2663 mL	60.5327 mL	75.6659 mL
5 mM	0.6053 mL	3.0266 mL	6.0533 mL	12.1065 mL	15.1332 mL
10 mM	0.3027 mL	1.5133 mL	3.0266 mL	6.0533 mL	7.5666 mL
50 mM	0.0605 mL	0.3027 mL	0.6053 mL	1.2107 mL	1.5133 mL
100 mM	0.0303 mL	0.1513 mL	0.3027 mL	0.6053 mL	0.7567 mL