| In vitro: |
| Chinese Traditional and Herbal Drugs, 2012,43(6): 1050-6. | | Chemical constituents of Clerodendrum lindleyi and their free radical scavenging activities[Reference: WebLink] | To study the chemical constituents from the roots and stems of Clerodendrum lindleyi and their in vitro activities of DPPH free radical scavenging.
METHODS AND RESULTS:
The constituents were isolated and purified by various column chromatographic techniques and their structures were identified on the basis of their physicochemical and spectral data.Free radical scavenging activity of the isolated constituents was investigated in vitro using the DPPH assay. Thirteen constituents were isolated from C.lindleyi and identified as betulinic acid(1),monoacetylmartinoside(2),4″-O-acetylmartynoside(3),Clerodenoside A(4),3″,4″-O-acetylmartynoside(5),acteoside(6),friedelin(7),glutinol(8),taraxerol(9),uncinatone(10),mandarone E(11),(24S)-24ethylcholesta-5,22,25-trien-3β-ol(12),and hedyotol C 4″-O-β-D-glucopyranoside(13).Compounds 1—6 were obtained from the roots and 7—13 were from the stems.Bioassay indicated that compounds 1—12 had different free radical scavenging activities.
CONCLUSIONS:
Compounds 1—13 are all obtained from C.lindleyi for the first time.
Compound 13 is obtained from the plants in Clerodendrum Linn.for the first time.Phenylethanoid glycosides,diterpenoids,triterpenoids,and sterol obtained show different free radical scavenging activities.Phenylethanoid glycosides 4″-O-acetylmartynoside,monoacetylmartinoside,and acteoside exhibit the most significant activity. |
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