黄芩黄酮II

Skullcapflavone II

	产品编号	CFN92216
	CAS编号	55084-08-7
	分子式 = 分子量	C₁₉H₁₈O₈ = 374.4
	产品纯度	>=98%
	物理属性	Yellow powder
	化合物类型	Flavonoids
	植物来源	The roots of Scutellaria baicalensis Georgi
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产品名称	产品编号	CAS编号	包装	QQ客服
黄芩黄酮II	CFN92216	55084-08-7	1mg	QQ客服：1413575084
黄芩黄酮II	CFN92216	55084-08-7	5mg	QQ客服：1413575084
黄芩黄酮II	CFN92216	55084-08-7	10mg	QQ客服：1413575084
黄芩黄酮II	CFN92216	55084-08-7	20mg	QQ客服：1413575084

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Description:

Targets:

TGF-β/Smad | COX

In vitro:

FASEB J . 2019 Feb;33(2):2026-2036.

Skullcapflavone II inhibits osteoclastogenesis by regulating reactive oxygen species and attenuates the survival and resorption function of osteoclasts by modulating integrin signaling[Pubmed: 30216110]

Abstract Many bone diseases, such as osteoporosis and rheumatoid arthritis, are attributed to an increase in osteoclast number or activity; therefore, control of osteoclasts has significant clinical implications. This study shows how skullcapflavone II (SFII), a flavonoid with anti-inflammatory activity, regulates osteoclast differentiation, survival, and function. SFII inhibited osteoclastogenesis with decreased activation of MAPKs, Src, and cAMP response element-binding protein (CREB), which have been known to be redox sensitive. SFII decreased reactive oxygen species by scavenging them or activating nuclear factor-erythroid 2-related factor 2 (Nrf2), and its effects were partially reversed by hydrogen peroxide cotreatment or Nrf2 deficiency. In addition, SFII attenuated survival, migration, and bone resorption, with a decrease in the expression of integrin β3, Src, and p130 Crk-associated substrate, and the activation of RhoA and Rac1 in differentiated osteoclasts. Furthermore, SFII inhibited osteoclast formation and bone loss in an inflammation- or ovariectomy-induced osteolytic mouse model. These findings suggest that SFII inhibits osteoclastogenesis through redox regulation of MAPKs, Src, and CREB and attenuates the survival and resorption function by modulating the integrin pathway in osteoclasts. SFII has therapeutic potential in the treatment and prevention of bone diseases caused by excessive osteoclast activity.-Lee, J., Son, H. S., Lee, H. I., Lee, G.-R., Jo, Y.-J., Hong, S.-E., Kim, N., Kwon, M., Kim, N. Y., Kim, H. J., Lee, Y. J., Seo, E. K., Jeong, W. Skullcapflavone II inhibits osteoclastogenesis by regulating reactive oxygen species and attenuates the survival and resorption function of osteoclasts by modulating integrin signaling.

In vivo:

Int Immunopharmacol. 2012 Apr;12(4):666-74.

Skullcapflavone II inhibits ovalbumin-induced airway inflammation in a mouse model of asthma.[Pubmed: 22314230]

Skullcapflavone II is a flavonoid derived from Scutellaria baicalensis, a widely used herbal medicine in anti-inflammatory and anticancer therapy in Korea. Skullcapflavone II antagonized the bradykinin receptor more potently than any of the other flavonoids derived from this plant.
METHODS AND RESULTS:
Here, we were investigated its therapeutic effects in a mouse model of ovalbumin (OVA)-induced allergic asthma. Administration of skullcapflavone II significantly reduced airway hyperresponsiveness (AHR), airway eosinophilia, Th2 cytokine production, and increased transforming growth factor-β1 (TGF-β1) levels in bronchoalveolarlavage (BAL) fluids and lungs from OVA-sensitized and -challenged mice. Skullcapflavone II administration also significantly suppressed subepithelial collagen deposition and goblet cell hyperplasia, elevated Smad7 expression and suppressed pSmad2/3 levels.
CONCLUSIONS:
Collectively, these findings indicate that skullcapflavone II, a potential bradykinin antagonist, reduced the major pathophysiological features of allergic asthma, at least in part by acting on TGF-β1/Smad signaling pathways. Thus, skullcapflavone II may have therapeutic potential for the treatment of allergic asthma.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
5'-甲氧基川陈皮素; 5'-Methoxynobiletin	CFN91940	6965-36-2	C₂₂H₂₄O₉ = 432.42	5mg	QQ客服：1457312923
粘毛黄芩素III; Viscidulin III	CFN97488	92519-91-0	C₁₇H₁₄O₈ = 346.3	20mg	QQ客服：1413575084
粘毛黄芩素III 四乙酸酯; Viscidulin III tetraacetate	CFN97545	96684-81-0	C₂₅H₂₂O₁₂ = 514.4	5mg	QQ客服：1413575084
粘毛黄芩素II; Viscidulin II	CFN92214	92519-93-2	C₁₇H₁₄O₇ = 330.3	5mg	QQ客服：1413575084
5,2',6'-三羟基-6,7,8-三甲氧基黄酮; 5,2',6'-Trihydroxy-6,7,8-trimethoxyflavone	CFN92215	98187-98-5	C₁₈H₁₆O₈ = 360.3	5mg	QQ客服：2056216494
半枝莲种素; Rivularin	CFN92217	70028-59-0	C₁₈H₁₆O₇ = 344.3	5mg	QQ客服：2159513211
黄芩黄酮II; Skullcapflavone II	CFN92216	55084-08-7	C₁₉H₁₈O₈ = 374.4	10mg	QQ客服：1457312923
3',5,5',7-四羟基-4',6-二甲氧基黄酮; 3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone	CFN99369	125537-92-0	C₁₇H₁₄O₈ = 346.3	5mg	QQ客服：215959384
5,7,3'-三羟基-6,4',5'-三甲氧基黄酮; 5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone	CFN90939	78417-26-2	C₁₈H₁₆O₈ = 360.3	5mg	QQ客服：3257982914
3'-Hydroxy-5,7,4',5'-Tetramethoxyflavone; 3'-Hydroxy-5,7,4',5'-Tetramethoxyflavone	CFN95397	29976-51-0	C₁₉H₁₈O₇ = 358.4	5mg	QQ客服：3257982914

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.6709 mL	13.3547 mL	26.7094 mL	53.4188 mL	66.7735 mL
5 mM	0.5342 mL	2.6709 mL	5.3419 mL	10.6838 mL	13.3547 mL
10 mM	0.2671 mL	1.3355 mL	2.6709 mL	5.3419 mL	6.6774 mL
50 mM	0.0534 mL	0.2671 mL	0.5342 mL	1.0684 mL	1.3355 mL
100 mM	0.0267 mL	0.1335 mL	0.2671 mL	0.5342 mL	0.6677 mL

黄芩黄酮II

Skullcapflavone II

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