5'-甲氧基川陈皮素

5'-Methoxynobiletin

	产品编号	CFN91940
	CAS编号	6965-36-2
	分子式 = 分子量	C₂₂H₂₄O₉ = 432.42
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Flavonoids
	植物来源	The herbs of Eupatorium coelestinum
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
5'-甲氧基川陈皮素	CFN91940	6965-36-2	1mg	QQ客服：2056216494
5'-甲氧基川陈皮素	CFN91940	6965-36-2	5mg	QQ客服：2056216494
5'-甲氧基川陈皮素	CFN91940	6965-36-2	10mg	QQ客服：2056216494
5'-甲氧基川陈皮素	CFN91940	6965-36-2	20mg	QQ客服：2056216494

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Institute of Pathophysiology Medical University of Vienna (Austria)

University of Parma (Italy)

Kyushu University (Japan)

S.N.D.T. Women's University (India)

University of Maryland (USA)

Helmholtz Zentrum München (Germany)

Center for protein Engineering (CIP) (Belgium)

University Medical Center Mainz (Germany)

Universidad de Buenos Aires (Argentina)

Kazusa DNA Research Institute (Japan)

Hamdard University (India)

Kyoto University (Japan)

University of Wollongong (Australia)

Celltrion Chemical Research Institute (Korea)

More...

Description:

5'-Methoxynobiletin may exhibit antinociceptive and anti-inflammatory activities in both formalin phases.

Targets:

PGE | IL Receptor | TNF-α

In vivo:

J Ethnopharmacol. 2016 Dec 24;194:369-377.

Antinociceptive and anti-inflammatory activities of standardized extract of polymethoxyflavones from Ageratum conyzoides.[Pubmed: 27633406]

Ageratum conyzoides L. is a plant widely used in traditional medicine in tropical and subtropical regions of the world due to its anti-inflammatory, antinociceptive and antibacterial properties. To characterize the standardized extract of polymethoxyflavones (SEPAc) from the plant and evaluate its antinociceptive and anti-inflammatory effects.
METHODS AND RESULTS:
The SEPAc purified from the ethanol extract of the plant leaves was characterized by high resolution mass spectrometry and the methoxyflavones were quantified by a validated UPLC-PDA method. The antinociceptive and anti-inflammatory activities of the SEPAc were evaluated after oral administration on the acute nocifensive behavior of mice induced by formalin, prostaglandin E2 (PGE2) and proinflammatory cytokines (interleukin-1beta (IL-1β)) and tumor necrosis factor-alpha (TNF-α) in mice. Qualitative analyses revealed the presence of seven methoxyflavones in the SEPAc, also a simple UPLC-PDA method was developed and validated for the quantification of 5,6,7,3',4',5'-hexametoxyflavone; nobiletin; 5'-Methoxynobiletin and eupalestin, major compounds in the extract. The SEPAc exhibited antinociceptive and anti-inflammatory activities in both formalin phases, with significant inhibition of the paw edema formation and significant reduction of the nocifensive response induced by an intraplantar injection of PGE2 and intrathecal injection of interleukin-1β.
CONCLUSIONS:
The SEPAc exhibited significant antinociceptive and anti-inflammatory effects. These results provided scientific suggestion of its potential as a source of new medicines to treat inflammatory diseases, such rheumatoid arthritis.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
3'-Hydroxy-5,7,4',5'-Tetramethoxyflavone; 3'-Hydroxy-5,7,4',5'-Tetramethoxyflavone	CFN95397	29976-51-0	C₁₉H₁₈O₇ = 358.4	5mg	QQ客服：2159513211
三粒小麦黄酮; Tricetin	CFN70392	520-31-0	C₁₅H₁₀O₇ = 302.2	10mg	QQ客服：1413575084
苜蓿素; Tricin	CFN98841	520-32-1	C₁₇H₁₄O₇ = 330.3	10mg	QQ客服：2056216494
4',5-二羟基-3',5',6,7-四甲氧基黄酮; 4',5-Dihydroxy-3',5',6,7-tetramethoxyflavone	CFN97322	83133-17-9	C₁₉H₁₈O₈ = 374.4	5mg	QQ客服：1413575084
5,3'-二羟基-6,7,4',5'-四甲氧基黄酮; 3',5-Dihydroxy-4',5',6,7-tetramethoxyflavone	CFN99214	111537-41-8	C₁₉H₁₈O₈ = 374.4	5mg	QQ客服：1457312923
5,7-二羟基-3',4',5'-三甲氧基黄酮; 5,7-Dihydroxy-3',4',5'-trimethoxyflavone	CFN96493	18103-42-9	C₁₈H₁₆O₇ = 344.32	5mg	QQ客服：2056216494
伞房花耳草素; Corymbosin	CFN96498	18103-41-8	C₁₉H₁₈O₇ = 358.34	5mg	QQ客服：1413575084
奇蒿黄酮; Arteanoflavone	CFN96510	68710-17-8	C₁₉H₁₈O₈ = 374.35	5mg	QQ客服：2159513211
3',4',5,5',6,7-六甲氧基黄酮; 3',4',5,5',6,7-Hexamethoxyflavone	CFN70332	29043-07-0	C₂₁H₂₂O₈ = 402.4	5mg	QQ客服：3257982914
4'-羟基-3',5,5',6,7,8-六甲氧基黄酮; 4'-Hydroxy-3',5,5',6,7,8-hexamethoxyflavone	CFN95407	85644-03-7	C₂₁H₂₂O₉ = 418.4	5mg	QQ客服：2159513211

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.3126 mL	11.5628 mL	23.1257 mL	46.2513 mL	57.8142 mL
5 mM	0.4625 mL	2.3126 mL	4.6251 mL	9.2503 mL	11.5628 mL
10 mM	0.2313 mL	1.1563 mL	2.3126 mL	4.6251 mL	5.7814 mL
50 mM	0.0463 mL	0.2313 mL	0.4625 mL	0.925 mL	1.1563 mL
100 mM	0.0231 mL	0.1156 mL	0.2313 mL	0.4625 mL	0.5781 mL