| In vitro: |
| Biochemical Pharmacology, 2017, 139:132. | | P22 Discovery of new bioactive compounds from (Dioclea reflexa Hook F.): Effective constituents of a traditional herbal medicine.[Reference: WebLink] |
METHODS AND RESULTS:
Three new flavonoids, reflevone 1, lexaflavanone 2 and lexaflavanol 3, together with, mearnsetin 4, 7,4’-dihydroxyflavone 5, sepinol 6, pallasin 7, 4-OMGA (3, 5-dihydroxyl-4-methoxylbenzoic acid) 8, Lupeol 9, Hederagenin 10 and a rare dipeptide, auratiamide acetate 11 were isolated from the ethyl acetate soluble part of the ethanolic root extract of Dioclea reflexa. Structures of the isolated compounds were elucidated by 1 and 2-dimensional NMR spectroscopy. The secondary metabolites were selectively examined for immunomodulatory, urease inhibitory, lypoxigenase inhibitory and free radical scavenging activities. Additionally, an in vitro cytotoxicity bioassay was carried on human non small cell lung cancer (NCI-H460).
CONCLUSIONS:
Our findings suggest that various activities of the new metabolites may indicate pharmacological potential against immune disorders, gastrointestinal ulcers and oxidative stress diseases. |
|
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)
