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  • 雪松素

    Cedrin

    雪松素
    产品编号 CFN97872
    CAS编号 75513-81-4
    分子式 = 分子量 C16H14O8 = 334.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Cedrus deodara
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    雪松素 CFN97872 75513-81-4 1mg QQ客服:2159513211
    雪松素 CFN97872 75513-81-4 5mg QQ客服:2159513211
    雪松素 CFN97872 75513-81-4 10mg QQ客服:2159513211
    雪松素 CFN97872 75513-81-4 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Pretoria (South Africa)
  • Griffith University (Australia)
  • University of Hertfordshire (United Kingdom)
  • Auburn University (USA)
  • Lodz University of Technology (Poland)
  • National Chung Hsing University (Taiwan)
  • Biotech R&D Institute (USA)
  • Deutsches Krebsforschungszentrum (Germany)
  • University of Perugia (Italy)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • Worcester Polytechnic Institute (USA)
  • Korea Institute of Oriental Medicine (Korea)
  • Ain Shams University (Egypt)
  • The Ohio State University (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2020 ,25(16):3697.
  • Sci Rep.2018, 8(1):12970
  • Pharmacol Rep.2018, 70(6):1195-1201
  • Nutrients.2020, 12(12):3638.
  • LWT2021, 150:112021.
  • Pharmacogn Mag.2015, 11:S585-91
  • J Pharm Biomed Anal.2017, 140:274-280
  • Natural Product Communications2020, doi: 10.1177.
  • Molecules 2022, 27(3),960.
  • Evid Based Complement Alternat Med.2018, 2018:3610494
  • FEBS J.2022, 10.1111:febs.16676.
  • Applied Biological Chemistry2022, 71:s13765-022-00743-5.
  • Sci Rep.2019, 9:19059
  • Research Square2022, rs.3.rs-1948239
  • Phytomedicine.2019, 67:153159
  • BMC Complement Med Ther. 2020, 20(1):94.
  • Food Res Int.2018, 106:909-919
  • Int J Mol Sci. 2014, 15(5):8443-57
  • Front Microbiol.2022, 13:835463.
  • Pharmaceutics.2023, 15(9):2355.
  • Int J Mol Sci.2020, 21(9):3392.
  • Sci Rep.2021, 11(1):21038.
  • J Cell Mol Med.2023, jcmm.17968.
  • ...
  • 生物活性
    Description: Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative stress, improvement of mitochondrial dysfunction and suppression of apoptosis.
    Targets: Bcl-2/Bax | Caspase | Beta Amyloid
    In vivo:
    Nat Prod Res. 2017 Jun 29:1-4.
    Cedrin identified from Cedrus deodara (Roxb.) G. Don protects PC12 cells against neurotoxicity induced by Aβ1-42.[Pubmed: 28658984 ]
    Alzheimer's disease is a severe neurodegenerative disease affecting elder worldwide and closely related to the neurotoxicity induced by amyloid β.
    METHODS AND RESULTS:
    To find efficient therapeutics, we have investigated the protective effects of Cedrin from Cedrus deodara (Roxb.) G. Don on PC12 cells against the neurotoxicity induced by amyloid β1-42. The results have shown the viability of PC12 cells injured by amyloid β1-42 can be improved by Cedrin. Cedrin can reduce reacrive oxygen species overproduction, increase the activity of superoxide dismutase and decrease malondialdehyde content. Meanwhile, the loss of mitochondrial membrane potential and mitochondrial permeability transition pore opening in PC12 cells, and elevated Caspase-3 activity, downregulated Bcl-2 and upregulated Bax are meliorated.
    CONCLUSIONS:
    These results demonstrate the protective effect of Cedrin is related to the inhibition of oxidative stress, improvement of mitochondrial dysfunction and suppression of apoptosis. This investigation gives evidences for the application of Cedrin in practice and further investigation in vivo.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.9913 mL 14.9566 mL 29.9133 mL 59.8265 mL 74.7831 mL
    5 mM 0.5983 mL 2.9913 mL 5.9827 mL 11.9653 mL 14.9566 mL
    10 mM 0.2991 mL 1.4957 mL 2.9913 mL 5.9827 mL 7.4783 mL
    50 mM 0.0598 mL 0.2991 mL 0.5983 mL 1.1965 mL 1.4957 mL
    100 mM 0.0299 mL 0.1496 mL 0.2991 mL 0.5983 mL 0.7478 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    花旗松素; Taxifolin CFN98734 480-18-2 C15H12O7 = 304.3 20mg QQ客服:3257982914
    李属素; Padmatin CFN97280 80453-44-7 C16H14O7 = 318.3 5mg QQ客服:1457312923
    雪松素 ; Deodarin CFN96563 33788-39-5 C16H14O7 = 318.29 5mg QQ客服:3257982914
    2',3,5,6',7-四羟基二氢黄烷酮; 2',3,5,6',7-Pentahydroxyflavanone CFN97277 80366-15-0 C15H12O7 = 304.3 5mg QQ客服:1457312923
    二氢桑色素; Dihydromorin CFN99854 18422-83-8 C15H12O7 = 304.3 5mg QQ客服:215959384
    二氢柽柳黄素; Dihydrotamarixetin CFN97194 70411-27-7 C16H14O7 = 318.3 5mg QQ客服:2056216494
    艾纳香素B; Blumeatin B CFN97274 79995-67-8 C17H16O7 = 332.3 5mg QQ客服:1413575084
    刺槐亭; Dihydrorobinetin CFN98671 4382-33-6 C15H12O7 = 304.3 5mg QQ客服:1457312923
    蛇葡萄素; 二氢杨梅素; Ampelopsin CFN98326 27200-12-0 C15H12O8 = 320.3 20mg QQ客服:2056216494
    异二氢杨梅素; Isodihydromyricetin CFN95765 119439-94-0 C15H12O8 = 320.3 10mg QQ客服:2159513211

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