番泻苷C

Sennoside C

	产品编号	CFN99905
	CAS编号	37271-16-2
	分子式 = 分子量	C₄₂H₄₀O₁₉ = 848.76
	产品纯度	>=98%
	物理属性	Yellow powder
	化合物类型	Anthraquinones
	植物来源	The leaves of Cassia angustifolia.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
番泻苷C	CFN99905	37271-16-2	1mg	QQ客服：215959384
番泻苷C	CFN99905	37271-16-2	5mg	QQ客服：215959384
番泻苷C	CFN99905	37271-16-2	10mg	QQ客服：215959384
番泻苷C	CFN99905	37271-16-2	20mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

MTT Agrifood Research Finland (Finland)

Mahatma Gandhi University (India)

University of Hertfordshire (United Kingdom)

Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)

University of Perugia (Italy)

University of Indonesia (Indonesia)

Chiang Mai University (Thailand)

Michigan State University (USA)

Monash University (Australia)

University of Mysore (India)

University of Sao Paulo (Brazil)

Shanghai Institute of Organic Chemistry (China)

Kyoto University (Japan)

Korea Food Research Institute(KFRI) (Korea)

More...

Description:

Sennoside C , aloe-emodin anthrone and rhein anthrone which formed mainly by intraluminal bacterial action, synergistically exert their purgative effects on mice.

In vitro:

Comput Biol Chem. 2011 Oct 12;35(5):293-7.

Drug-target network and polypharmacology studies of a Traditional Chinese Medicine for type II diabetes mellitus.[Pubmed: 22000800]

Many Traditional Chinese Medicines (TCMs) are effective to relieve complicated diseases such as type II diabetes mellitus (T2DM).
METHODS AND RESULTS:
In this work, molecular docking and network analysis were employed to elucidate the action mechanism of a medical composition which had clinical efficacy for T2DM. We found that multiple active compounds contained in this medical composition would target multiple proteins related to T2DM and the biological network would be shifted. We predicted the key players in the medical composition and some of them have been reported in literature. Meanwhile, several compounds such as Rheidin A, Rheidin C, Sennoside C, procyanidin C1 and Dihydrobaicalin were notable although no one have reported their pharmacological activity against T2DM.
CONCLUSIONS:
The association between active compounds, target proteins and other diseases was also discussed.

In vivo:

J Pharm Pharmacol. 1992 Dec;44(12):973-6.

Metabolic activation of sennoside C in mice: synergistic action of anthrones.[Pubmed: 1361561]

METHODS AND RESULTS:
Sennosides A and C directly injected into the caecum of mice showed equal purgative activity. Intracaecal administration reduced time to onset of diarrhoea induced by Sennoside C from about 3 h after oral administration to about 24 min. At 2.3 h after oral administration of Sennoside C, nearly equimolar amounts of aloe-emodin anthrone and rhein anthrone were detected in the large intestine of mice. The purgative effect of oral Sennoside C could be reduced by pretreating mice with chloramphenicol. This was observed as a decreased formation of total anthrones in the large intestine. Both anthrones and an equimolar mixture of both anthrones directly injected into the caecum exerted a purgative effect, although the activity was lower for aloe-emodin anthrone. The intracaecal ED50 values were 54.5 (24.1-89.6), 11.4 (5.0-15.7) and 11.2 (6.1-14.6) mumol kg-1 for aloe-emodin anthrone, rhein anthrone and an equimolar mixture of both anthrones, respectively.
CONCLUSIONS:
We concluded that aloe-emodin anthrone and rhein anthrone, formed mainly by intraluminal bacterial action, are the true active metabolites of Sennoside C in mice and that both anthrones synergistically exert their purgative effects on mice.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
番泻苷元B; Sennidin B	CFN99598	517-44-2	C₃₀H₁₈O₁₀ = 538.46	5mg	QQ客服：215959384
番泻苷A; Sennoside A	CFN99903	81-27-6	C₄₂H₃₈O₂₀ = 862.74	20mg	QQ客服：1457312923
番泻苷B; Sennoside B	CFN99904	128-57-4	C₄₂H₃₈O₂₀ = 862.74	20mg	QQ客服：3257982914
番泻苷C; Sennoside C	CFN99905	37271-16-2	C₄₂H₄₀O₁₉ = 848.76	10mg	QQ客服：1457312923
番泻苷D; Sennoside D	CFN99906	37271-17-3	C₄₂H₄₀O₁₉ = 848.76	5mg	QQ客服：1413575084
1,5,7'-联大黄素甲醚; Floribundone 1	CFN97845	118555-84-3	C₃₂H₂₂O₁₀ = 566.52	5mg	QQ客服：1413575084
原金丝桃素; Protohypericin	CFN93055	548-03-8	C₃₀H₁₈O₈ = 506.46	5mg	QQ客服：2159513211
金丝桃素; Hypericin	CFN99188	548-04-9	C₃₀H₁₆O₈ = 504.45	20mg	QQ客服：2056216494
伪金丝桃素; Pseudohypericin	CFN99591	55954-61-5	C₃₀H₁₆O₉ = 520.44	5mg	QQ客服：2159513211
原伪金丝桃素; Protopseudohypericin	CFN90677	54328-09-5	C₃₀H₁₈O₉ = 522.46	10mg	QQ客服：1457312923

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.1782 mL	5.8909 mL	11.7819 mL	23.5638 mL	29.4547 mL
5 mM	0.2356 mL	1.1782 mL	2.3564 mL	4.7128 mL	5.8909 mL
10 mM	0.1178 mL	0.5891 mL	1.1782 mL	2.3564 mL	2.9455 mL
50 mM	0.0236 mL	0.1178 mL	0.2356 mL	0.4713 mL	0.5891 mL
100 mM	0.0118 mL	0.0589 mL	0.1178 mL	0.2356 mL	0.2945 mL

番泻苷C

Sennoside C

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