番泻苷B

Sennoside B

	产品编号	CFN99904
	CAS编号	128-57-4
	分子式 = 分子量	C₄₂H₃₈O₂₀ = 862.74
	产品纯度	>=98%
	物理属性	Yellow powder
	化合物类型	Anthraquinones
	植物来源	The leaves of Cassia angustifolia.
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产品名称	产品编号	CAS编号	包装	QQ客服
番泻苷B	CFN99904	128-57-4	10mg	QQ客服：215959384
番泻苷B	CFN99904	128-57-4	20mg	QQ客服：215959384
番泻苷B	CFN99904	128-57-4	50mg	QQ客服：215959384
番泻苷B	CFN99904	128-57-4	100mg	QQ客服：215959384

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Description:

Sennoside B, a major purgative component, has a potential utility in the treatment of proliferative diseases, through inhibiting PDGF-stimulated cell proliferation by binding to PDGF-BB and its receptor and by down-regulating the PDGFR-beta signaling pathway. It and sennoside A also possess significant gastroprotective activities .

Targets:

PGE | ATPase | Potassium Channel | PDGFR | STAT | ERK | Akt

In vitro:

Life Sci. 2009 Jun 19;84(25-26):915-22.

Sennoside B inhibits PDGF receptor signaling and cell proliferation induced by PDGF-BB in human osteosarcoma cells.[Pubmed: 19393247]

AIMS: To address the possibility that sennoside B inhibition of cell proliferation is mediated via interference with platelet-derived growth factor (PDGF) signaling. MAIN METHODS: Human osteosarcoma MG63 cells were treated with PDGF in the presence or absence of sennoside B. Activation of the PDGF signaling pathway was monitored using western immunoblotting with specific antibodies against the PDGF receptor, phosphotyrosine and components of the downstream signaling cascade. Activation of cell metabolism and proliferation was assessed by chromogenic reduction of MTT. KEY FINDINGS: Sennoside B was found to inhibit PDGF-BB-induced phosphorylation of the PDGF receptor (PDGFR) in human MG63 osteosarcoma cells. Downstream signaling was also affected; pre-incubation of PDGF-BB with sennoside B inhibited the phosphorylation of pathway components including Ak strain To address the possibility that Sennoside B inhibition of cell proliferation is mediated via interference with platelet-derived growth factor (PDGF) signaling.
METHODS AND RESULTS:
Human osteosarcoma MG63 cells were treated with PDGF in the presence or absence of Sennoside B. Activation of the PDGF signaling pathway was monitored using western immunoblotting with specific antibodies against the PDGF receptor, phosphotyrosine and components of the downstream signaling cascade. Activation of cell metabolism and proliferation was assessed by chromogenic reduction of MTT. Sennoside B was found to inhibit PDGF-BB-induced phosphorylation of the PDGF receptor (PDGFR) in human MG63 osteosarcoma cells. Downstream signaling was also affected; pre-incubation of PDGF-BB with Sennoside B inhibited the phosphorylation of pathway components including Ak strain transforming protein (AKT), signal transducer and activator of transcription 5 (STAT-5) and extracellular signal-regulated kinase 1/2 (ERK1/2). Further, we found that Sennoside B can bind directly to the extracellular domains of both PDGF-BB and the PDGF-beta receptor (PDGFR-beta). The effect was specific for Sennoside B; other similar compounds including aloe-emodin, rhein and the meso isomer (sennoside A) failed to inhibit PDGFR activation or downstream signaling. Sennoside B also inhibited PDGF-BB stimulation of MG63 cell proliferation.
CONCLUSIONS:
These results indicate that Sennoside B can inhibit PDGF-stimulated cell proliferation by binding to PDGF-BB and its receptor and by down-regulating the PDGFR-beta signaling pathway. Sennoside B is therefore of potential utility in the treatment of proliferative diseases in which PDGF signaling plays a central role.

In vivo:

J Drug Target. 2015 Feb;23(2):180-90.

Experimental evaluation of radioiodinated sennoside B as a necrosis-avid tracer agent.[Pubmed: 25330022]

Necrosis-avid agents are a class of compounds that selectively accumulate in the necrotic tissues after systemic administration, which can be used for in vivo necrosis imaging and targeted therapies.
METHODS AND RESULTS:
In order to search for a necrosis-avid tracer agent with improved drugability, we labelled iodine-131 on Sennoside B (SB) as a naturally occurring median dianthrone compound. The necrosis targetability and clearance properties of (131)I-Sennoside B were evaluated in model rats with liver and muscle necrosis. On SPECT/CT images, a "hot spot" in the infarcted liver lobe and necrotic muscle was persistently observed at 24 h and 72 h post-injection (p.i.). Gamma counting of the tissues of interest revealed a radioactivity ratio of necrotic to viable liver at 4.6 and 3.4 and of necrotic to viable muscle at 7.0 and 8.8 at 24 h and 72 h p.i., respectively. The good match of autoradiographs and fluoromicroscopic images with corresponding histochemical staining suggested preferential uptake of (131)I-Sennoside B in necrotic tissue. Pharmacokinetic study revealed that (131)I-Sennoside B has an elimination half-life of 8.6 h.
CONCLUSIONS:
This study indicates that (131)I-Sennoside B shows not only prominent necrosis avidity but also favourable pharmacokinetics, which may serve as a potential necrosis-avid diagnostic agent for assessment of tissue viability.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
番泻苷A; Sennoside A	CFN99903	81-27-6	C₄₂H₃₈O₂₀ = 862.74	20mg	QQ客服：2159513211
番泻苷B; Sennoside B	CFN99904	128-57-4	C₄₂H₃₈O₂₀ = 862.74	20mg	QQ客服：2056216494
番泻苷C; Sennoside C	CFN99905	37271-16-2	C₄₂H₄₀O₁₉ = 848.76	10mg	QQ客服：3257982914
番泻苷D; Sennoside D	CFN99906	37271-17-3	C₄₂H₄₀O₁₉ = 848.76	5mg	QQ客服：215959384
1,5,7'-联大黄素甲醚; Floribundone 1	CFN97845	118555-84-3	C₃₂H₂₂O₁₀ = 566.52	5mg	QQ客服：3257982914
原金丝桃素; Protohypericin	CFN93055	548-03-8	C₃₀H₁₈O₈ = 506.46	5mg	QQ客服：2159513211
金丝桃素; Hypericin	CFN99188	548-04-9	C₃₀H₁₆O₈ = 504.45	20mg	QQ客服：3257982914
伪金丝桃素; Pseudohypericin	CFN99591	55954-61-5	C₃₀H₁₆O₉ = 520.44	5mg	QQ客服：1413575084
原伪金丝桃素; Protopseudohypericin	CFN90677	54328-09-5	C₃₀H₁₈O₉ = 522.46	10mg	QQ客服：2056216494
番泻苷元A; Sennidin A	CFN99597	641-12-3	C₃₀H₁₈O₁₀ = 538.46	5mg	QQ客服：3257982914

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.1591 mL	5.7955 mL	11.591 mL	23.182 mL	28.9774 mL
5 mM	0.2318 mL	1.1591 mL	2.3182 mL	4.6364 mL	5.7955 mL
10 mM	0.1159 mL	0.5795 mL	1.1591 mL	2.3182 mL	2.8977 mL
50 mM	0.0232 mL	0.1159 mL	0.2318 mL	0.4636 mL	0.5795 mL
100 mM	0.0116 mL	0.058 mL	0.1159 mL	0.2318 mL	0.2898 mL

番泻苷B

Sennoside B

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