五味子酚

Schisanhenol

	产品编号	CFN90364
	CAS编号	69363-14-0
	分子式 = 分子量	C₂₃H₃₀O₆ = 402.48
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Lignans
	植物来源	The fruits of Schisandrachinensis (Turcz.) Baill
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
五味子酚	CFN90364	69363-14-0	10mg	QQ客服：215959384
五味子酚	CFN90364	69363-14-0	20mg	QQ客服：215959384
五味子酚	CFN90364	69363-14-0	50mg	QQ客服：215959384
五味子酚	CFN90364	69363-14-0	100mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Description:

Schisanhenol has antioxidative effect on human LDL oxidation, may be through scavenging free radicals; it also has anti-apoptosis effect on BACSs, may be related to its inhibition of ROS generation. Schisanhenol can protect against adriamycin induced heart mitochondrial toxicity.

Targets:

ROS | LDL | ATPase

In vitro:

Fitoterapia. 2015 Mar;101:117-24.

Schisanhenol derivatives and their biological evaluation against tobacco mosaic virus (TMV).[Pubmed: 25598185]

Schisanhenol (Sol) was isolated from Schisandra rubriflora, and a series of derivatives (1-16, 15a-16a, and 15b-16b) were designed and prepared by chemical modification. The curative and protective effects of these dibenzocyclooctadiene lignan analogues against tobacco mosaic virus (TMV) were evaluated.
METHODS AND RESULTS:
Most analogues exhibited stronger protective effects than the positive control ningnanmycin. Dibromoschisanhenol (6) at 0.25mM exhibited the strongest protective activity (83.5±1.8% at 0.25mM), and 14-(3, 5-dibenzyloxy)-benzoyloxyschisanhenol (16) showed a significant curative effect (78.0±3.8% at 0.15mM) that was much stronger than that of the commercial virucide ningnanmycin.
CONCLUSIONS:
This study is the first to demonstrate that natural dibenzocyclooctadiene lignans and analogues are active against plant viruses.

Biomed Environ Sci. 1992 Mar;5(1):57-64.

Protective effect of schisanhenol against oxygen radical induced mitochondrial toxicity on rat heart and liver.[Pubmed: 1586468]

Schisanhenol (SAL) had been shown to have potent antioxidant activities. The protective effects of SAL against oxygen radical induced mitochondrial injuries of rat heart and liver were investigated in the present study.
METHODS AND RESULTS:
The ferrous-cysteine induced mitochondrial lipid peroxidation was significantly inhibited by SAL, while the loss of ATPase activity induced by the lipid peroxidation was prevented. The rigidification of mitochondrial membrane, as well as swelling, lysis and disintegration of the mitochondria induced by ferrous-cysteine were all significantly inhibited by SAL.
CONCLUSIONS:
These results further confirm that SAL possesses antioxidant activity.

In vivo:

Sheng Li Ke Xue Jin Zhan. 1998 Jan;29(1):35-8.

Protective effects of schisanhenol, salvianolic acid A and SY-L on oxidative stress induced injuries of cerebral cells and their mechanisms.[Pubmed: 12501701]

Oxidative stress may play an important role in neuronal degenerative diseases such as Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis. These disorders make the elderly not being able to live normally and move freely. So it is necessary to find effective antioxidants to prevent or cure the aged persons from diseases related to neuronal degeneration.
METHODS AND RESULTS:
Schisanhenol (Sal) and salvianolic acid A (Sal A) are known antioxidants which were isolated from Chinese herbs respectively. SY-L is a totally synthetic new compound.
CONCLUSIONS:
The results showed that Sal, Sal A and SY-L significantly protect cerebral cells from the injuries induced by oxidative stress.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
异南五味子木脂宁; Isokadsuranin	CFN90912	82467-52-5	C₂₃H₂₈O₆ = 400.46	5mg	QQ客服：2056216494
五脂酮C; Schisanlignone C	CFN92723	144606-83-7	C₂₃H₂₆O₇ = 414.5	5mg	QQ客服：3257982914
五味子丙素; Schizandrin C	CFN99708	61301-33-5	C₂₂H₂₄O₆ = 384.42	20mg	QQ客服：3257982914
五脂酮D; Schisanlignone D	CFN92724	144606-84-8	C₂₂H₂₂O₇ = 398.4	5mg	QQ客服：1457312923
环氧五味子丙素; Schisandrin C epoxide	CFN92841	81345-36-0	C₂₂H₂₂O₇ = 398.4	5mg	QQ客服：1457312923
Rubrisandrin A; Rubrisandrin A	CFN92278	919289-30-8	C₂₂H₂₈O₆ = 388.5	5mg	QQ客服：1457312923
五味子甲素; Schizandrin A	CFN99922	61281-38-7	C₂₄H₃₂O₆ = 416.51	20mg	QQ客服：1413575084
五味子醇甲; Schisandrol A	CFN99012	7432-28-2	C₂₄H₃₂O₇ = 432.5	20mg	QQ客服：1457312923
五脂酮A; Schisanlignone A	CFN92722	135557-67-4	C₂₄H₃₀O₇ = 430.5	5mg	QQ客服：3257982914
戈米辛N; Gomisin N	CFN90125	69176-52-9	C₂₃H₂₈O₆ = 400.46	20mg	QQ客服：215959384

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.4846 mL	12.423 mL	24.846 mL	49.6919 mL	62.1149 mL
5 mM	0.4969 mL	2.4846 mL	4.9692 mL	9.9384 mL	12.423 mL
10 mM	0.2485 mL	1.2423 mL	2.4846 mL	4.9692 mL	6.2115 mL
50 mM	0.0497 mL	0.2485 mL	0.4969 mL	0.9938 mL	1.2423 mL
100 mM	0.0248 mL	0.1242 mL	0.2485 mL	0.4969 mL	0.6211 mL

五味子酚

Schisanhenol

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