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  • 戈米辛N

    Gomisin N

    产品编号 CFN90125
    CAS编号 69176-52-9
    分子式 = 分子量 C23H28O6 = 400.46
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The fruits of Schizandra chinensis
    产品名称 产品编号 CAS编号 包装 QQ客服
    戈米辛N CFN90125 69176-52-9 10mg QQ客服:1413575084
    戈米辛N CFN90125 69176-52-9 20mg QQ客服:1413575084
    戈米辛N CFN90125 69176-52-9 50mg QQ客服:1413575084
    戈米辛N CFN90125 69176-52-9 100mg QQ客服:1413575084
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
  • CSIRO - Agriculture Flagship (Australia)
  • VIT University (India)
  • FORTH-IMBB (Greece)
  • Washington State University (USA)
  • The University of Newcastle (Australia)
  • Universiti Malaysia Pahang (Malaysia)
  • Hamdard University (India)
  • Chungnam National University (Korea)
  • Seoul National University of Science and Technology (Korea)
  • Subang Jaya Medical Centre (Malaysia)
  • Tohoku University (Japan)
  • University of Bordeaux (France)
  • Celltrion Chemical Research Institute (Korea)
  • MTT Agrifood Research Finland (Finland)
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  • ...
  • 生物活性
    Description: Gomisin N has anti-oxdiant, anti-inflammatory, anti-cancer and anti-hepatitis activities; it produces beneficial sedative and hypnotic bioactivity, which may be mediated by the modification of the serotonergic and GABAergic system. Gomisin N can enhance TNF-α-induced apoptosis by suppressing of NF-κB and EGFR signaling pathways, and potentiate TRAIL-induced apoptosis through ROS-mediated up-regulation of death receptors 4 and 5.
    Targets: GABA Receptor | 5-HT Receptor | PARP | Caspase | ROS | NO | NOS | NF-kB | p65 | COX | IL Receptor | TNF-α | EGFR | IkB | Bcl-2/Bax | p53 | IKK
    In vitro:
    Immunopharmacol Immunotoxicol. 2011 Dec;33(4):709-13.
    Gomisin N has anti-allergic effect and inhibits inflammatory cytokine expression in mouse bone marrow-derived mast cells.[Pubmed: 21401384 ]
    Gomisin N is a bioactive compound and a prominent anti-allergic agent found in the fruits of tree Schizandra chinensis. However, its effects on the bone marrow-derived mast cell (BMMC)-mediated allergy and inflammation mechanism remain unknown.
    In this study, the biological effects of gomisin were evaluated while focusing on its effects on the allergic mediator in PMA + A23187-stimulated BMMCs. The anti-allergic effect of gomisin has shown that inhibited PMA + A23187-induced interleukin-6 (IL-6) production. An investigation was also conducted to determine its effects on the production of several allergic mediators including prostaglandin D(2) (PGD(2)), leukotriene C(4) (LTC(4)), β-hexosaminidase (β-Hex), and cyclooxygenase-2 (COX-2) protein. The results revealed that gomisin inhibited the PMA + A23187-induced production of IL-6, PGD(2), LTC(4), β-Hex, and COX-2 protein.
    Taken together, these findings indicate that gomisin N has the potential for use in the treatment of allergy.
    Mol Med Rep. 2009 Sep-Oct;2(5):725-32.
    Gomisin N isolated from Schisandra chinensis significantly induces anti-proliferative and pro-apoptotic effects in hepatic carcinoma.[Pubmed: 21475892]
    Lignans isolated from Schisandria chinensis have been prescribed as anti-cancer and anti-hepatitis treatments in Chinese medicine. To investigate the applications of lignans isolated from Schisandria chinensis in hepatic carcinoma therapy, their apoptotic ability was screened using a cell proliferation assay.
    Compared to the other lignans, gomisin N induced high apoptotic levels in hepatic carcinoma. Cell morphology and flow cytometric analysis demonstrated that this lignan induced cell death at high concentrations, but did not induce any changes at low concentrations. In addition, the expression levels of Bcl-2 and Bax proteins, which are involved in the apoptotic pathway, were markedly increased in only the 320 μM-treated group compared to the vehicle and other concentration groups, while the expression level of p53 protein remained unchanged in this group.
    These results suggest that gomisin N is an anti-cancer drug candidate capable of inhibiting the proliferation and inducing the apoptosis of human hepatic carcinomas.
    In vivo:
    Fitoterapia. 2014 Jul;96:123-30.
    Gomisin N isolated from Schisandra chinensis augments pentobarbital-induced sleep behaviors through the modification of the serotonergic and GABAergic system.[Pubmed: 24785966 ]
    The fruits of Schisandra chinensis have been used for the treatment of insomnia in oriental countries for more than thousands of years. However, the pharmacological properties and the mechanism of sedative and hypnotic effects have not yet been studied. Gomisin N is one of the major bioactive constituents from the fruits of Schisandra chinensis, and in this paper we reported a detailed study on the effects and mechanisms of Gomisin N on its sedative and hypnotic activity for the first time.
    These results implied that Gomisin N possessed weak sedative effects on locomotion activity in normal mice, and produced a dose-dependent(5-45 mg/kg, i.p.) increase in sleep duration in pentobarbital-treated mice, thus, itself did not induce sleep at higher dose which was used in this experiment (45 mg/kg, i.p.). It also can reverse the rodent models of insomnia induced by p-chlorophenylalanine (PCPA) and caffeine, which could exhibit a synergistic effect with 5-hydroxytryptophan (5-HTP) as well; furthermore, the hypnotic effects of Gomisin N were inhibited by flumazenil (a specific GABAA-BZD receptor antagonist).
    Altogether, these results indicated that Gomisin N produced beneficial sedative and hypnotic bioactivity, which might be mediated by the modification of the serotonergic and GABAergic system.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4971 mL 12.4856 mL 24.9713 mL 49.9426 mL 62.4282 mL
    5 mM 0.4994 mL 2.4971 mL 4.9943 mL 9.9885 mL 12.4856 mL
    10 mM 0.2497 mL 1.2486 mL 2.4971 mL 4.9943 mL 6.2428 mL
    50 mM 0.0499 mL 0.2497 mL 0.4994 mL 0.9989 mL 1.2486 mL
    100 mM 0.025 mL 0.1249 mL 0.2497 mL 0.4994 mL 0.6243 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    R(+)-戈米辛M1; R(+)-Gomisin M1 CFN97309 82467-50-3 C22H26O6 = 386.4 5mg QQ客服:215959384
    五味子酚; Schisanhenol CFN90364 69363-14-0 C23H30O6 = 402.48 20mg QQ客服:2056216494
    戈米辛 K1; Gomisin K1 CFN96724 75629-20-8 C23H30O6 = 402.48 5mg QQ客服:3257982914
    戈米辛M2; Gomisin M2 CFN97306 82425-45-4 C22H26O6 = 386.4 5mg QQ客服:215959384
    戈米辛 L1; Gomisin L1 CFN96734 82425-43-2 C22H26O6 = 386.44 5mg QQ客服:1457312923
    戈米辛 L2; Gomisin L2 CFN96726 82425-44-3 C22H26O6 = 386.44 5mg QQ客服:2159513211
    异南五味子木脂宁; Isokadsuranin CFN90912 82467-52-5 C23H28O6 = 400.46 5mg QQ客服:2159513211
    五脂酮C; Schisanlignone C CFN92723 144606-83-7 C23H26O7 = 414.5 5mg QQ客服:1457312923
    五味子丙素; Schizandrin C CFN99708 61301-33-5 C22H24O6 = 384.42 20mg QQ客服:2056216494
    五脂酮D; Schisanlignone D CFN92724 144606-84-8 C22H22O7 = 398.4 5mg QQ客服:215959384





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