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  • 桑根酮D

    Sanggenone D

    桑根酮D
    产品编号 CFN99704
    CAS编号 81422-93-7
    分子式 = 分子量 C40H36O12 = 708.71
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The root barks of Morus alba L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    桑根酮D CFN99704 81422-93-7 10mg QQ客服:215959384
    桑根酮D CFN99704 81422-93-7 20mg QQ客服:215959384
    桑根酮D CFN99704 81422-93-7 50mg QQ客服:215959384
    桑根酮D CFN99704 81422-93-7 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Monash University Malaysia (Malaysia)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • S.N.D.T. Women's University (India)
  • The Australian National University (Australia)
  • University of Illinois (USA)
  • The Ohio State University (USA)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • University of Auckland (New Zealand)
  • University of Queensland (Australia)
  • Universidade de Franca (Brazil)
  • University of Helsinki (Finland)
  • Nanjing University of Chinese Medicine (China)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Biochem Mol Toxicol.2021, 35(5):e22731.
  • Pharmacol Rep.2020, 72(2):472-480.
  • J Biosci.2020, 45:46.
  • EXCLI J.2023, 22:482-498.
  • The Japan Society for Analy. Chem.2017, 66(8):613-617
  • Phytomedicine.2016, 23(4):331-9
  • Molecules.2020, 25(15):3353.
  • Primary and Industrial.2018, 52(11)
  • Int Immunopharmacol.2020, 90:107268.
  • Food Chem.2021, 337:128023.
  • VNU Journal of Science2023, 39(2):24-33.
  • Phytomedicine.2019, 65:153089
  • Environ Toxicol.2021, doi: 10.1002
  • Molecules 2021, 26(4),1092.
  • Nutrients.2021, 13(8):2901.
  • J Biochem Mol Toxicol.2022, e23211.
  • Evid Based Complement Alternat Med.2018, 2018:8565132
  • Acta Biochim Pol.2015, 62(2):253-8
  • Mol Neurobiol.2022, 02873-9.
  • Molecules.2021, 26(19):6032.
  • Int. Conference on Med. Sci. and Bio.2017, 17973
  • J Nat Prod.2017, 80(4):854-863
  • Microchemical Journal2024: 196:109676.
  • ...
  • 生物活性
    Description: Sanggenone D represents a new scaffold of positive GABAA receptor modulators, it also inhibits COX-2 activity (IC 50 = 73-100 μM). Sanggenone D has anti-inflammatory activity, it can inhibit NO production from lipopolysaccharide (LPS)-induced RAW 264.7 cells at > 10 uM; inhibition of nitric oxide production was mediated by suppression of iNOS enzyme induction but not by direct inhibition of iNOS enzyme activity.
    Targets: GABA Receptor | COX | NOS | NO
    In vitro:
    J Agric Food Chem. 2006 Nov 1;54(22):8432-6.
    Venturia inaequalis-inhibiting Diels-Alder adducts from Morus root bark.[Pubmed: 17061817 ]
    In organic apple orcharding there is a continuous need for natural fungicides effective against Venturia inaequalis (Cooke) Winter, the causal agent of apple scab.
    METHODS AND RESULTS:
    In this study an in vitro assay is presented for determining the germination inhibitory potential of extracts and pure compounds. From a screening of plant extracts, the methanol extract of Morus root bark revealed distinct V. inaequalis inhibiting qualities, which were subjected to a bioguided fractionation.
    CONCLUSIONS:
    Among the isolated metabolites [moracins M (1), O/P (2), kuwanon L (3), and Sanggenone D (4), Sanggenone B (5), Sanggenone G (6), Sanggenone O (7), Sanggenone E (8), and Sanggenone C (9)] all the Diels-Alder adducts (3-9) showed an antifungal activity with IC50 values between 10 and 123 microM. The in vitro activity of the most active fraction (A5, IC50 39.0 +/- 4.2 microg/mL) was evaluated in vivo, confirming a distinct antifungal activity against V. inaequalis for the tested natural material.
    Biochem Pharmacol. 2001 Nov 1;62(9):1185-91.
    Effects of naturally occurring prenylated flavonoids on enzymes metabolizing arachidonic acid: cyclooxygenases and lipoxygenases.[Pubmed: 11705451]
    Prenylated flavonoids are chemical entities having an isoprenyl, a geranyl, a 1,1-dimethylallyl, and/or a lavandulyl moiety as part of their flavonoid backbone structure.
    METHODS AND RESULTS:
    In this study, the effects of 19 naturally occurring prenylated flavonoids, isolated from medicinal plants, on cyclooxygenase (COX)-1 and COX-2 and on 5-lipoxygenase (5-LOX) and 12-LOX were investigated using [14C]arachidonic acid as a substrate. The homogenates of bovine platelets and polymorphonuclear leukocytes were used as COX-1, 12-LOX, and 5-LOX enzyme sources; the homogenate of aspirin-pretreated lipopolysaccharide-induced RAW 264.7 cells was used for the COX-2 enzyme source. Among the 19 prenylated flavonoids, morusin, kuwanon C, sanggenone B, Sanggenone D and kazinol B inhibited COX-2 activity (ic(50) = 73-100 microM), but the potencies were far less than that of NS-398 (ic(50) = 2.9 microM). In contrast, many prenylated flavonoids, such as kuraridin, kuwanon C and sophoraisoflavanone A, inhibited COX-1 activity. Of the COX-1 inhibiting prenylated flavonoids, kuraridin, kurarinone, and sophoraflavanone G, all having a C-8 lavandulyl moiety, showed potent activity (ic(50) = 0.1 to 1 microM) comparable to that of indomethacin (ic(50) = 0.7 microM). Most of the prenylated flavonoids tested inhibited 5-LOX activity with ic(50) values ranging from 0.09 to 100 microM. Of these, only kuwanon C, papyriflavonol A and sophoraflavanone G showed inhibitory activity against 12-LOX at low concentration ranges (ic(50) = 19-69 microM) comparable to that of NDGA (ic(50) = 2.6 microM).
    CONCLUSIONS:
    Our results suggest that the position and the nature of the prenyl substitution greatly influence in vitro biological activities of these molecules.
    In vivo:
    Planta Med. 2000 Oct;66(7):596-600.
    Effects of prenylated flavonoids and biflavonoids on lipopolysaccharide-induced nitric oxide production from the mouse macrophage cell line RAW 264.7.[Pubmed: 11105561 ]
    Certain flavonoid derivatives possess anti-inflammatory activity in vitro and in vivo. Besides their antioxidative properties and effects on the arachidonic acid metabolism including cyclooxygenase/lipoxygenase inhibition, some flavones and flavonols were previously found to show inhibitory activity on nitric oxide production by inducible nitric oxide synthase (iNOS; NOS type 2) through suppression of iNOS induction.
    METHODS AND RESULTS:
    As part of our continuing investigations, the effects of unique and minor flavonoids (prenylated flavonoids and biflavonoids) on nitric oxide production from lipopolysaccharide-induced macrophage cell line (RAW 264.7) were evaluated in order to establish their inhibitory activity on NO production and correlate this action with their in vivo anti-inflammatory potential. Among the derivatives tested, prenylated compounds including morusin, kuwanon C, and sanggenon D and biflavonoids such as bilobetin and ginkgetin were found to inhibit NO production from lipopolysaccharide (LPS)-induced RAW 264.7 cells at > 10 microM. Inhibition of nitric oxide production was mediated by suppression of iNOS enzyme induction but not by direct inhibition of iNOS enzyme activity. An exception was echinoisoflavanone that inhibited iNOS enzyme activity (IC50 = 83 microM) and suppressed iNOS enzyme induction as well. While most prenylated derivatives showed cytotoxicity to RAW cells at 10-100 microM, all biflavonoids tested were not cytotoxic.
    CONCLUSIONS:
    Since nitric oxide (NO) produced by inducible NO synthase (iNOS) plays an important role in inflammatory disorders, inhibition of NO production by these flavonoids may contribute, at least in part, to their anti-inflammatory and immunoregulating potential in vivo.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.411 mL 7.0551 mL 14.1101 mL 28.2203 mL 35.2754 mL
    5 mM 0.2822 mL 1.411 mL 2.822 mL 5.6441 mL 7.0551 mL
    10 mM 0.1411 mL 0.7055 mL 1.411 mL 2.822 mL 3.5275 mL
    50 mM 0.0282 mL 0.1411 mL 0.2822 mL 0.5644 mL 0.7055 mL
    100 mM 0.0141 mL 0.0706 mL 0.1411 mL 0.2822 mL 0.3528 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    去氢毒灰叶酚; 6A,12A-二去氢-alpha-毒灰叶酚; Dehydrotoxicarol CFN96085 59086-93-0 C23H20O7 = 408.4 5mg QQ客服:3257982914
    二氢鱼藤酮; Dihydrorotenone CFN90585 6659-45-6 C23H24O6 = 396.43 5mg QQ客服:2159513211
    鱼藤酮; Rotenone CFN98590 83-79-4 C23H22O6 = 394.42 20mg QQ客服:1413575084
    12alpha-羟基鱼藤酮; 12-alpha-Hydroxyrotenone CFN91633 509-96-6 C23H22O7 = 410.4 5mg QQ客服:2056216494
    3'-羟基鱼藤酮; Amorphigenin CFN91624 4208-09-7 C23H22O7 = 410.42 5mg QQ客服:1413575084
    12-脱氧代-12ALPHA-乙酰氧基鱼藤酮; 12-Deoxo-12alpha-acetoxyelliptone CFN97933 150226-21-4 C22H20O7 = 396.4 5mg QQ客服:2056216494
    Lupinol C; Lupinol C CFN97939 135905-53-2 C20H18O7 = 370.4 5mg QQ客服:1413575084
    Coccineone B; Coccineone B CFN96204 135626-13-0 C16H10O6 = 298.3 5mg QQ客服:1457312923
    黄细心酮 0; Boeravinone O CFN96403 1449384-21-7 C17H12O7 = 328.3 5mg QQ客服:2056216494
    黄细心酮B; Boeravinone B CFN96206 114567-34-9 C17H12O6 = 312.3 5mg QQ客服:2056216494

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