红花黄色素 A

Safflor Yellow A

	产品编号	CFN90262
	CAS编号	85532-77-0
	分子式 = 分子量	C₂₇H₃₀O₁₅ = 594.52
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Chalcones
	植物来源	The stigma of Crocus sativus L.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
红花黄色素 A	CFN90262	85532-77-0	1mg	QQ客服：2159513211
红花黄色素 A	CFN90262	85532-77-0	5mg	QQ客服：2159513211
红花黄色素 A	CFN90262	85532-77-0	10mg	QQ客服：2159513211
红花黄色素 A	CFN90262	85532-77-0	20mg	QQ客服：2159513211

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Universita' Degli Studi Di Cagliari (Italy)

University of Wisconsin-Madison (USA)

University of Indonesia (Indonesia)

Universiti Sains Malaysia (Malaysia)

The Ohio State University (USA)

Indian Institute of Science (India)

Periyar University (India)

Sanford Burnham Medical Research Institute (USA)

Universidad de La Salle (Mexico)

Kyung Hee University (Korea)

Guangzhou Institutes of Biomedicine and Health (China)

Korea Intitute of Science and Technology (KIST) (Korea)

University of Melbourne (Australia)

Kamphaengphet Rajabhat University (Thailand)

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Description:

Safflor Yellow A protects cultured rat cardiomyocytes against A/R injury, maybe via inhibiting cellular oxidative stress and apoptosis.

Targets:

Bcl-2/Bax | Caspase | SOD

In vitro:

Acta Pharmacol Sin. 2013 Apr;34(4):487-95.

Safflor yellow A protects neonatal rat cardiomyocytes against anoxia/reoxygenation injury in vitro.[Pubmed: 23396376]

To investigate the effects of Safflor Yellow A (SYA), a flavonoid extracted from Carthamus tinctorius L, on cultured rat cardiomyocytes exposed to anoxia/reoxygenation (A/R).
METHODS AND RESULTS:
Primary cultured neonatal rat cardiomyocytes were exposed to anoxia for 3 h followed by reoxygenation for 6 h. The cell viability was measured using MTT assay. The releases of lactate dehydrogenase (LDH) and creatine kinase (CK), level of malondialdehyde (MDA), and activities of glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) were analyzed. Hoechst 33258 staining and changes in Bcl-2/Bax ratio and caspase 3 activity were used to examine A/R-induced apoptosis. The A/R exposure markedly decreased the viability of cardiomyocytes, suppressed the activities of SOD, GSH, CAT and GSH-Px, and Bcl-2 protein expression. Meanwhile, the A/R exposure markedly increased the release of LDH and CK, and MDA production in the cardiomyocytes, and increased the rate of apoptosis, caspase 3 activity, Bax protein expression. Pretreatment with Safflor Yellow A (40, 60 and 80 nmol/L) concentration-dependently blocked the A/R-induced changes in the cardiomyocytes. Pretreatment of the cardiomyocytes with the antioxidant N-acetylcysteine (NAC, 200 μmol/L) produced protective effects that were comparable to those caused by Safflor Yellow A (80 nmol/L).
CONCLUSIONS:
Safflor Yellow A protects cultured rat cardiomyocytes against A/R injury, maybe via inhibiting cellular oxidative stress and apoptosis.

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.682 mL	8.4101 mL	16.8203 mL	33.6406 mL	42.0507 mL
5 mM	0.3364 mL	1.682 mL	3.3641 mL	6.7281 mL	8.4101 mL
10 mM	0.1682 mL	0.841 mL	1.682 mL	3.3641 mL	4.2051 mL
50 mM	0.0336 mL	0.1682 mL	0.3364 mL	0.6728 mL	0.841 mL
100 mM	0.0168 mL	0.0841 mL	0.1682 mL	0.3364 mL	0.4205 mL