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  • 羟基红花黄色素A

    Hydroxysafflor yellow A

    产品编号 CFN99950
    CAS编号 78281-02-4
    分子式 = 分子量 C27H32O16 = 612.53
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Chalcones
    植物来源 The stigma of Crocus sativus L.
    产品名称 产品编号 CAS编号 包装 QQ客服
    羟基红花黄色素A CFN99950 78281-02-4 10mg QQ客服:215959384
    羟基红花黄色素A CFN99950 78281-02-4 20mg QQ客服:215959384
    羟基红花黄色素A CFN99950 78281-02-4 50mg QQ客服:215959384
    羟基红花黄色素A CFN99950 78281-02-4 100mg QQ客服:215959384
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  • Centralised Purchases Unit (CPU), B.I.T.S (India)
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  • 生物活性
    Description: Hydroxysafflor yellow A(H-A) possesses hepatoprotective, anti-inflammatory, and anti-tumor activities, it can effectively protect the liver of rats from long-term alcohol injury, which relates with the enhanced antioxidant capacity of liver tissues and inhibition of TGF-β1 expression, it also inhibited angiogenesis of hepatocellular carcinoma via blocking ERK/MAPK and NF-κB signaling pathway in H22 tumor-bearing mice. H-A also can provide protection to H9c2 cardiomyocytes against A/R-induced apoptosis by the upregulation of HO-1 expression through the PI3K/Akt/Nrf2 signaling pathway.
    Targets: TGF-β/Smad | ERK | Raf | p38MAPK | NF-kB | p65 | IkB | VEGFR | ROS | IL Receptor | TNF-α | TLR | JNK | PI3K | Akt | Nrf2 | Bcl-2/Bax | HIF | IKK | HO-1
    In vitro:
    Int J Cardiol. 2012 Oct 4;160(2):95-101.
    Upregulation of heme oxygenase-1 expression by hydroxysafflor yellow A conferring protection from anoxia/reoxygenation-induced apoptosis in H9c2 cardiomyocytes.[Pubmed: 21497407 ]
    Reperfusion therapy is widely utilized for acute myocardial infarction (AMI), so ischemia/reperfusion (I/R) of the heart is frequently encountered in clinical practice. The curative effects of reperfusion therapy for AMI are favourable in most cases, but reperfusion can also cause harmful effect to cardiomyocytes. Hydroxysafflor yellow A (HSYA) is an effective therapeutic agent to alleviate I/R injury, but the mechanisms underlying this therapeutic effect are unknown.
    The H9c2 cardiomyocyte cell line was incubated with or without HSYA during hypoxia, then it was reoxygenated. In the presence of HSYA, reoxygenation resulted in the upregulated expression and activity of heme oxygenase-1 (HO-1), phosphorylation of Akt, translocation of nuclear factor Nrf2, and most importantly, a reduction in A/R-induced apoptosis. An HO-1 inhibitor completely suppressed HO-1 enzymatic activity upregulated by HSYA and notably diminished the anti-apoptotic effect of HSYA. An inhibitor of PI3K, completely blocked Akt phosphorylation induced by HSYA and partly negated HSYA-induced upregulation of HO-1, translocation of nuclear factor Nrf2 and suppression of apoptosis in the H9c2 cardiomyocytes.
    Our study suggests that HSYA can provide protection to H9c2 cardiomyocytes against A/R-induced apoptosis. This protective effect largely depends on the upregulation of HO-1 expression through the PI3K/Akt/Nrf2 signaling pathway.
    J Cardiovasc Pharmacol. 2008 Aug;52(2):191-202.
    Hydroxysafflor yellow A enhances survival of vascular endothelial cells under hypoxia via upregulation of the HIF-1 alpha-VEGF pathway and regulation of Bcl-2/Bax.[Pubmed: 18670359 ]
    Hydroxysafflor yellow A (HSYA) is a component of the flower Carthamus tinctorius L. The present investigation determines whether HSYA can modify the effects of hypoxia on vascular endothelial cells (EC) and its mechanisms.
    Human EC line (EAhy926) viability was determined using the MTT assay. EC cycle phase distribution was done with PI staining and flow cytometric analysis, and EC apoptosis was done by AnnexinV-FITC detection and the TUNEL assay. The protein levels of VEGF, Bcl-2, Bax, and HIF-1 alpha were determined by ELISA or Western blot analysis, and the mRNA expression of these genes by RT-PCR analysis. HIF-1 alpha transcriptional activity was measured using a reporter gene assay. HSYA improved cell viability under hypoxia in a concentration-dependent manner by attenuating its cycle arrest and inhibiting its apoptosis. HSYA upregulated the bcl-2/bax ratio, which is downregulated under hypoxia, increased VEGF protein concentration and VEGF mRNA expression and enhanced HIF-1 alpha protein accumulation and its transcriptional activity.
    In conclusion, HSAY could enhance the survival of ECs under hypoxia, which may be correlated with its effect of upregulating the bcl-2/bax ratio and promoting HIF-1 alpha protein accumulation, which increases VEGF. These findings provide evidence for the mechanisms by which HSYA maintains EC survival under hypoxia.
    Int J Clin Exp Med . 2015 Apr 15;8(4):5295-302.
    Hydroxysafflor yellow A inhibits lipopolysaccharide-induced proliferation and migration of vascular smooth muscle cells via Toll-like receptor-4 pathway[Pubmed: 26131104]
    Abstract Abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) is closely associated with early vascular hyperplasic lesions. Toll-like receptor (TLR)-4 is a pathogen pattern recognition receptor expressed on VSMCs, and can be activated by lipopolysaccharide. Activated TLR-4 plays a promoting role in VSMCs proliferation and migration through the downstream signaling pathways including Rac1/Akt. Hydroxysafflor yellow A (HSYA) is the main component of the safflower yellow pigments, which has long been used for the treatment of cardiovascular diseases in traditional Chinese medicine. However, the effect of HSYA on VSMC proliferation and migration remains unknown. In the present study, we showed that HYSA could inhibit LPS-induced VSMCs proliferation and migration, accompanied by the downregulated levels of several key pro-inflammatory cytokines, including TNF-α, IL-6, and IL-8. We further showed that HYSA inhibited LPS-induced upregulation of TLR-4 expression as well as the activation of Rac1/Akt pathway, suggesting that HSYA inhibits LPS-induced VSMCs proliferation and migration, partly at least, via inhibition of TLR-4/Rac1/Akt pathway. Accordingly, HSYA may be used as a promising agent for prevention and treatment of vascular hyperplasic disorders. Keywords: Hydroxysafflor yellow A; lipopolysaccharide; migration; proliferation; vascular smooth muscle cell.
    In vivo:
    J Physiol Biochem. 2015 Mar;71(1):69-78.
    Protective effects of hydroxysafflor yellow A (HSYA) on alcohol-induced liver injury in rats.[Pubmed: 25626885]
    Hydroxysafflor yellow A (HSYA), the main active natural constituent extracted from Carthamus tinctorius L., has been widely used for the treatment of cerebrovascular and cardiovascular diseases.
    The aim of this study is to explore the effect of Hydroxysafflor yellow A on alcohol-induced liver injury and the underlying mechanism. Male Sprague-Dawley rats were used to establish the liver injury model induced by alcohol. Hydroxysafflor yellow A treatment ameliorated serum biochemical indicators by reducing the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), hyaluronan (HA), laminin (LN), and type III precollagen (III-C) in rats. Hydroxysafflor yellow A efficiently increased the activity and messenger RNA (mRNA) of superoxide dismutase (SOD) and glutathione peroxidase (GPx) in rat liver tissue compared with those of model group, which was obviously reduced by alcohol. Hydroxysafflor yellow A also apparently decreased the levels of reactive oxygen species (ROS) and malondialdehyde (MDA) in rat liver tissue compared with those of model group, which was obviously enhanced by alcohol. Histological studies demonstrated that Hydroxysafflor yellow A substantially reduced the number of macro- and micro-vesicular steatosis, suppressed hepatic fibrogenesis and shrunk ballooning degeneration areas, ameliorated the severity of liver damage induced by long-term drinking, and finally improved the liver architecture. In addition, immunohistochemistry study indicated that the activation of transforming growth factor β1 (TGF-β1) stimulated by alcohol in rat liver tissue was significantly blocked by Hydroxysafflor yellow A .
    Collectively, these data demonstrated that Hydroxysafflor yellow A can effectively protect the liver of rats from long-term alcohol injury, which relates with the enhanced antioxidant capacity of liver tissues and inhibition of TGF-β1 expression.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6326 mL 8.1629 mL 16.3257 mL 32.6515 mL 40.8143 mL
    5 mM 0.3265 mL 1.6326 mL 3.2651 mL 6.5303 mL 8.1629 mL
    10 mM 0.1633 mL 0.8163 mL 1.6326 mL 3.2651 mL 4.0814 mL
    50 mM 0.0327 mL 0.1633 mL 0.3265 mL 0.653 mL 0.8163 mL
    100 mM 0.0163 mL 0.0816 mL 0.1633 mL 0.3265 mL 0.4081 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    红花黄色素 A; Safflor Yellow A CFN90262 85532-77-0 C27H30O15 = 594.52 5mg QQ客服:2159513211
    羟基红花黄色素A; Hydroxysafflor yellow A CFN99950 78281-02-4 C27H32O16 = 612.53 20mg QQ客服:215959384





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