玫瑰菌素

Rosenonolactone

	产品编号	CFN98805
	CAS编号	508-71-4
	分子式 = 分子量	C₂₀H₂₈O₃ = 316.4
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Diterpenoids
	植物来源	The roots of Cyperus rotundus.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
玫瑰菌素	CFN98805	508-71-4	1mg	QQ客服：215959384
玫瑰菌素	CFN98805	508-71-4	5mg	QQ客服：215959384
玫瑰菌素	CFN98805	508-71-4	10mg	QQ客服：215959384
玫瑰菌素	CFN98805	508-71-4	20mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Ioannina (Greece)

University of Otago (New Zealand)

St. Jude Children Research Hospital (USA)

University of Vigo (Spain)

Melbourne University (Australia)

Universidade do Porto (Portugal)

Instituto Politécnico de Bragan?a (Portugal)

Universidade de Franca (Brazil)

Agricultural Research Organization (ARO) (Israel)

University of East Anglia (United Kingdom)

Aveiro University (Portugal)

Universidad de La Salle (Mexico)

Auburn University (USA)

Universita' Degli Studi Di Cagliari (Italy)

More...

Description:

Rosenonolactone shows inhibitory activity against prolyl endopeptidase and thrombin.

In vitro:

Mycotoxin Res. 1992 Sep;8(2):77-83.

DNA strand break induction, mutagenicity, and cytotoxicity of the mycotoxins 11-β-hydroxy-7-deoxy-rosenonolactone, rosenonolactone, and trichothecin.[Pubmed: 23606003]

11-β-hydroxy-7-deoxy-Rosenonolactone (TSS1), a mycotoxin of the rosenane class, was tested on cytotoxicity, induction of DNA single strand breaks and muta-genicity. Its effects were compared to those of Rosenonolactone and trichothecin.
METHODS AND RESULTS:
TSS1 had stronger antibiotic activity againstEscherichia coli (EC 50: 10μg/mL) than Rosenonolactone (EC 50: >200μg/mL) but weaker activity than trichothecin (EC 50: 3μg/mL). The same order of activity was found for the inhibition of yeast fermentation (EC 50 of TSS1: 45μg/mL; EC 50 of Rosenonolactone: > 120μg/mL; EC 50 of trichothecin: 3.4μg/mL).In the trypan blue exclusion test using V79 Chinese hamster cells, TSS1 proved to be cytotoxic (EC50: 30μg/mL) at even lower doses than trichothecin (EC50: 200μg/mL). Rosenonolactone had no significant toxicity up to the highest soluble concentration (500μg/mL).DNA single strand breaks caused by TSS1 occurred at the same concentrations at which damage of the cell membrane became apparent. For trichothecin single strand breaks were detected only at concentrations at which the membrane was already highly damaged. No single strand breaks were observed in V79 cells after incubation with Rosenonolactone up to the limit of solubility (500μg/mL).
CONCLUSIONS:
In the reversion assay withhis Salmonella typhimurium strains TA 98 and TA 100, no mutagenicity was observed for any of the examined mycotoxins up to 800μg/plate with and without the addition of a rat liver preparation for metabolism of the test compound.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Orthosiphol A; Orthosiphol A	CFN95442	142741-25-1	C₃₈H₄₄O₁₁ = 676.8	5mg	QQ客服：3257982914
Neoorthosiphol A; Neoorthosiphol A	CFN95447	243448-72-8	C₃₈H₄₄O₁₂ = 692.8	10mg	QQ客服：1457312923
15-异海松烯-8,18-二醇; 15-Isopimarene-8,18-diol	CFN97214	73002-86-5	C₂₀H₃₄O₂ = 306.5	5mg	QQ客服：2056216494
Toonaciliatin M; Toonaciliatin M	CFN92899	93930-04-2	C₂₀H₃₂O₃ = 320.47	5mg	QQ客服：3257982914
8(14),15-异海松二烯-3,18-二醇; 8(14),15-Isopimaradiene-3,18-diol	CFN97003	59219-64-6	C₂₀H₃₂O₂ = 304.5	5mg	QQ客服：215959384
Hugorosenone; Hugorosenone	CFN92876	217096-49-6	C₂₀H₃₀O₂ = 302.4	5mg	QQ客服：215959384
Yucalexin P-17; Yucalexin P-17	CFN96300	119642-82-9	C₂₀H₃₀O₃ = 318.5	5mg	QQ客服：215959384
长白楤木酸; Continentalic acid	CFN90861	19889-23-7	C₂₀H₃₀O₂ = 302.5	20mg	QQ客服：1413575084
海松酸; Pimaric acid	CFN99382	127-27-5	C₂₀H₃₀O₂ = 302.5	5mg	QQ客服：2159513211
异海松酸; Isopimaric acid	CFN97723	5835-26-7	C₂₀H₃₀O₂ = 302.46	5mg	QQ客服：2159513211

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.1606 mL	15.8028 mL	31.6056 mL	63.2111 mL	79.0139 mL
5 mM	0.6321 mL	3.1606 mL	6.3211 mL	12.6422 mL	15.8028 mL
10 mM	0.3161 mL	1.5803 mL	3.1606 mL	6.3211 mL	7.9014 mL
50 mM	0.0632 mL	0.3161 mL	0.6321 mL	1.2642 mL	1.5803 mL
100 mM	0.0316 mL	0.158 mL	0.3161 mL	0.6321 mL	0.7901 mL