异海松酸

Isopimaric acid

	产品编号	CFN97723
	CAS编号	5835-26-7
	分子式 = 分子量	C₂₀H₃₀O₂ = 302.46
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Diterpenoids
	植物来源	The herbs of Daemonorops draco Blume
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
异海松酸	CFN97723	5835-26-7	1mg	QQ客服：2159513211
异海松酸	CFN97723	5835-26-7	5mg	QQ客服：2159513211
异海松酸	CFN97723	5835-26-7	10mg	QQ客服：2159513211
异海松酸	CFN97723	5835-26-7	20mg	QQ客服：2159513211

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Aveiro University (Portugal)

Sant Gadge Baba Amravati University (India)

Subang Jaya Medical Centre (Malaysia)

University of Parma (Italy)

University of Hertfordshire (United Kingdom)

University of Hull (United Kingdom)

Shanghai Institute of Organic Chemistry (China)

Monash University Malaysia (Malaysia)

Kazusa DNA Research Institute (Japan)

Sanford Burnham Medical Research Institute (USA)

University of Toronto (Canada)

Julius Kühn-Institut (Germany)

University of Perugia (Italy)

Institute of Pathophysiology Medical University of Vienna (Austria)

More...

Description:

Isopimaric acid is active against MDR and MRSA strains of S. aureus which are becoming increasingly resistant to antibiotics, the minimum inhibitory concentrations (MIC) are 32-64 microg/mL . Isopimaric acid is also possible that an antagonistic interaction with reserpine may render the antibiotics inactive.

Targets:

Antifection

In vitro:

Phytother Res. 2005 Jun;19(6):538-42.

Isopimaric acid from Pinus nigra shows activity against multidrug-resistant and EMRSA strains of Staphylococcus aureus.[Pubmed: 16114093]

METHODS AND RESULTS:
The diterpene Isopimaric acid was extracted from the immature cones of Pinus nigra (Arnold) using bioassay-guided fractionation of a crude hexane extract. Isopimaric acid was assayed against multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA). The minimum inhibitory concentrations (MIC) were 32-64 microg/mL and compared with a commercially obtained resin acid, abietic acid, with MICs of 64 microg/mL. Resin acids are known to have antibacterial activity and are valued in traditional medicine for their antiseptic properties. These results show that Isopimaric acid is active against MDR and MRSA strains of S. aureus which are becoming increasingly resistant to antibiotics. Both compounds were evaluated for modulation activity in combination with antibiotics, but did not potentiate the activity of the antibiotics tested. However, the compounds were also assayed in combination with the efflux pump inhibitor reserpine, to see if inhibition of the TetK or NorA efflux pump increased their activity. Interestingly, rather than a potentiation of activity by a reduction in MIC, a two to four-fold increase in MIC was seen.
CONCLUSIONS:
It may be that Isopimaric acid and abietic acid are not substrates for these efflux pumps, but it is also possible that an antagonistic interaction with reserpine may render the antibiotics inactive. 1H-NMR of abietic acid and reserpine taken individually and in combination, revealed a shift in resonance of some peaks for both compounds when mixed together compared with the spectra of the compounds on their own. It is proposed that this may be due to complex formation between abietic acid and reserpine and that this complex formation is responsible for a reduction in activity and elevation of MIC.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Neoorthosiphol A; Neoorthosiphol A	CFN95447	243448-72-8	C₃₈H₄₄O₁₂ = 692.8	10mg	QQ客服：1457312923
15-异海松烯-8,18-二醇; 15-Isopimarene-8,18-diol	CFN97214	73002-86-5	C₂₀H₃₄O₂ = 306.5	5mg	QQ客服：3257982914
Toonaciliatin M; Toonaciliatin M	CFN92899	93930-04-2	C₂₀H₃₂O₃ = 320.47	5mg	QQ客服：215959384
8(14),15-异海松二烯-3,18-二醇; 8(14),15-Isopimaradiene-3,18-diol	CFN97003	59219-64-6	C₂₀H₃₂O₂ = 304.5	5mg	QQ客服：3257982914
Hugorosenone; Hugorosenone	CFN92876	217096-49-6	C₂₀H₃₀O₂ = 302.4	5mg	QQ客服：1413575084
Yucalexin P-17; Yucalexin P-17	CFN96300	119642-82-9	C₂₀H₃₀O₃ = 318.5	5mg	QQ客服：1457312923
长白楤木酸; Continentalic acid	CFN90861	19889-23-7	C₂₀H₃₀O₂ = 302.5	20mg	QQ客服：1413575084
海松酸; Pimaric acid	CFN99382	127-27-5	C₂₀H₃₀O₂ = 302.5	5mg	QQ客服：2159513211
异海松酸; Isopimaric acid	CFN97723	5835-26-7	C₂₀H₃₀O₂ = 302.46	5mg	QQ客服：3257982914
玫瑰菌素; Rosenonolactone	CFN98805	508-71-4	C₂₀H₂₈O₃ = 316.4	5mg	QQ客服：215959384

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.3062 mL	16.5311 mL	33.0622 mL	66.1244 mL	82.6556 mL
5 mM	0.6612 mL	3.3062 mL	6.6124 mL	13.2249 mL	16.5311 mL
10 mM	0.3306 mL	1.6531 mL	3.3062 mL	6.6124 mL	8.2656 mL
50 mM	0.0661 mL	0.3306 mL	0.6612 mL	1.3225 mL	1.6531 mL
100 mM	0.0331 mL	0.1653 mL	0.3306 mL	0.6612 mL	0.8266 mL