异海松酸
Isopimaric acid
|
|
产品编号 |
CFN97723 |
| CAS编号 |
5835-26-7 |
| 分子式 = 分子量 |
C20H30O2 = 302.46 |
| 产品纯度 |
>=98% |
| 物理属性 |
Powder |
| 化合物类型 |
Diterpenoids |
| 植物来源 |
The herbs of Daemonorops draco Blume |
| ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 异海松酸 |
CFN97723 |
5835-26-7 |
1mg |
QQ客服：1413575084 |
| 异海松酸 |
CFN97723 |
5835-26-7 |
5mg |
QQ客服：1413575084 |
| 异海松酸 |
CFN97723 |
5835-26-7 |
10mg |
QQ客服：1413575084 |
| 异海松酸 |
CFN97723 |
5835-26-7 |
20mg |
QQ客服：1413575084 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
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Korea Food Research Institute(KFRI) (Korea)
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Sanford Burnham Medical Research Institute (USA)
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Nicolaus Copernicus Uniwersity (Poland)
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Universidad Industrial de Santander (Colombia)
Universidade do Porto (Portugal)
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国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
Isopimaric acid is active against MDR and MRSA strains of S. aureus which are becoming increasingly resistant to antibiotics, the minimum inhibitory concentrations (MIC) are 32-64 microg/mL .
Isopimaric acid is also possible that an antagonistic interaction with reserpine may render the antibiotics inactive. |
| Targets: |
Antifection |
| In vitro: |
| Phytother Res. 2005 Jun;19(6):538-42. | | Isopimaric acid from Pinus nigra shows activity against multidrug-resistant and EMRSA strains of Staphylococcus aureus.[Pubmed: 16114093] |
METHODS AND RESULTS:
The diterpene Isopimaric acid was extracted from the immature cones of Pinus nigra (Arnold) using bioassay-guided fractionation of a crude hexane extract. Isopimaric acid was assayed against multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA). The minimum inhibitory concentrations (MIC) were 32-64 microg/mL and compared with a commercially obtained resin acid, abietic acid, with MICs of 64 microg/mL. Resin acids are known to have antibacterial activity and are valued in traditional medicine for their antiseptic properties. These results show that Isopimaric acid is active against MDR and MRSA strains of S. aureus which are becoming increasingly resistant to antibiotics. Both compounds were evaluated for modulation activity in combination with antibiotics, but did not potentiate the activity of the antibiotics tested. However, the compounds were also assayed in combination with the efflux pump inhibitor reserpine, to see if inhibition of the TetK or NorA efflux pump increased their activity. Interestingly, rather than a potentiation of activity by a reduction in MIC, a two to four-fold increase in MIC was seen.
CONCLUSIONS:
It may be that Isopimaric acid and abietic acid are not substrates for these efflux pumps, but it is also possible that an antagonistic interaction with reserpine may render the antibiotics inactive. 1H-NMR of abietic acid and reserpine taken individually and in combination, revealed a shift in resonance of some peaks for both compounds when mixed together compared with the spectra of the compounds on their own. It is proposed that this may be due to complex formation between abietic acid and reserpine and that this complex formation is responsible for a reduction in activity and elevation of MIC. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
3.3062 mL |
16.5311 mL |
33.0622 mL |
66.1244 mL |
82.6556 mL |
| 5 mM |
0.6612 mL |
3.3062 mL |
6.6124 mL |
13.2249 mL |
16.5311 mL |
| 10 mM |
0.3306 mL |
1.6531 mL |
3.3062 mL |
6.6124 mL |
8.2656 mL |
| 50 mM |
0.0661 mL |
0.3306 mL |
0.6612 mL |
1.3225 mL |
1.6531 mL |
| 100 mM |
0.0331 mL |
0.1653 mL |
0.3306 mL |
0.6612 mL |
0.8266 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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