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  • Rosamultin

    • Rosamultin

    Rosamultin

    Rosamultin
    		产品编号 CFN89097
    CAS编号 88515-58-6
    分子式 = 分子量 C36H58O10 = 650.85
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The roots of Rosa rugosa.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Rosamultin CFN89097 88515-58-6 10mg QQ客服：2056216494
    Rosamultin CFN89097 88515-58-6 20mg QQ客服：2056216494
    Rosamultin CFN89097 88515-58-6 50mg QQ客服：2056216494
    Rosamultin CFN89097 88515-58-6 100mg QQ客服：2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • Pennsylvania State University (USA)
  • Harvard University (USA)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • University of Padjajaran (Indonesia)
  • Colorado State University (USA)
  • University of Otago (New Zealand)
  • Almansora University (Egypt)
  • Indian Institute of Science (India)
  • The Ohio State University (USA)
  • Universita' Degli Studi Di Cagliari (Italy)
  • Universidade Católica Portuguesa (Portugal)
  • University Medical Center Mainz (Germany)
  • University of Bonn (Germany)
  • Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)
  • More...
    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pharmaceuticals (Basel).2022, 15(5):591.
  • Food and Fermentation Industries2018, 44(371)
  • Front Chem.2022, 10:1048467.
  • Fitoterapia.2022, 105141.
  • Fitoterapia.2024, 175:105955.
  • Onco Targets Ther.2017, 10:3467-3474
  • Front Cell Dev Biol.2020, 8:32.
  • J Herbmed Pharmacol.2018, 7(4):280-286
  • Pharmaceuticals (Basel).2021, 14(10):1046.
  • Biomolecules.2019, 9(11):E696
  • Food Structure2023, 36:100324.
  • Evid Based Complement Alternat Med.2018, 2018:4580627
  • Biol Pharm Bull.2018, 41(11):1645-1651
  • Foods.2021, 10(11):2754.
  • Chem Biol Interact.2020, 328:109200.
  • Molecules.2022, 27(22):7997.
  • J Chromatogr B Analyt Technol Biomed Life Sci. 2017, 1064:115-123
  • Viruses2023, 15(6), 1377
  • Front Microbiol.2023, 14:921653.
  • Food Chem.2019, 278:683-691
  • Biomed Chromatogr.2019, 8:e4774
  • Sci Rep. 2017, 17332(7)
  • Sci Rep.2021, 11(1):10931.
  • ...
    • 生物活性
    Description: Rosamultin has antioxidant, antiinflammatory/antinociceptive properties, it may protect against bromobenzene-induced hepatotoxicity through, at least in part, enhanced activity of epoxide hydrolase. Rosamultin has anti-human immunodeficiency virus (HIV) activity, it inhibited HIV-1 protease by 53% at a concentration of 100 microM.
    Targets: HIV | Immunology & Inflammation related
    In vitro:
    J Med Food. 2005 Spring;8(1):107-9.
    Anti-HIV protease activity from rosa family plant extracts and rosamultin from Rosa rugosa.[Pubmed: 15857219 ]

    METHODS AND RESULTS:
    To identify substances with anti-human immunodeficiency virus (HIV) activity from plant sources, 12 extracts of Rosa family plants were screened for their inhibitory effects against HIV-1 protease. Of the extracts tested, the strongest inhibitory effects were observed in the root of Rosa rugosa and the leaves of Prunus sargentii, at a concentration of 100 microg/mL.
    CONCLUSIONS:
    Rosamultin isolated from the root of R. rugosa inhibited HIV-1 protease by 53% at a concentration of 100 microM.
    In vivo:
    Biol Pharm Bull. 2005 Jan;28(1):101-4.
    19Alpha-hydroxyursane-type triterpenoids: antinociceptive anti-inflammatory principles of the roots of Rosa rugosa.[Pubmed: 15635171]
    To search for antiinflammtory 19alpha-hydroxyursane-type triterpenoids, the MeOH extract of the roots of Rosa rugosa (Rosaceae) was fractionated.
    METHODS AND RESULTS:
    The active fraction of the EtOAc extract was hydrolyzed in alkaline solution to give a hydrolyzed fraction. Both extracts showed antiinflammatory/antinociceptive action in acetic acid-induced writhing and hot plate testing and in a carrageenan-induced paw edema model in mice and rats. Repeated chromatography of the EtOAc extract on both silica gel and octadecylsilane columns led to the isolation of kaji-ichigoside F1 (1, euscaphic acid 28-O-glucoside) and Rosamultin (2, tormentic acid 28-O-glucoside). The hydrolyzed fraction was also subjected to silica gel column and octadecylsilane column chromatography to produce euscaphic acid (3) and tormentic acid (4). The potencies were observed in the following order: 4>3>2>1.
    CONCLUSIONS:
    These results suggest that 19alpha-hydroxyursane-type triterpenoids are responsible for the antiinflammatory/antinociceptive action of R. rugosa roots.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.5365 mL 7.6823 mL 15.3645 mL 30.729 mL 38.4113 mL
    5 mM 0.3073 mL 1.5365 mL 3.0729 mL 6.1458 mL 7.6823 mL
    10 mM 0.1536 mL 0.7682 mL 1.5365 mL 3.0729 mL 3.8411 mL
    50 mM 0.0307 mL 0.1536 mL 0.3073 mL 0.6146 mL 0.7682 mL
    100 mM 0.0154 mL 0.0768 mL 0.1536 mL 0.3073 mL 0.3841 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    6,19-二羟基乌苏-12-烯-3-氧代-28-酸; 6,19-Dihydroxyurs-12-en-3-oxo-28-oic acid CFN99892 194027-11-7 C30H46O5 = 486.7 5mg QQ客服：1457312923
    3beta-(alpha-L-Arabinopyranosyloxy)urs-12,18-dien-28-oic acid beta-D-glucopyranosyl ester; 3beta-(alpha-L-Arabinopyranosyloxy)urs-12,18-dien-28-oic acid beta-D-glucopyranosyl ester CFN95459 435269-07-1 C41H64O12 = 749.0 20mg QQ客服：3257982914
    Oblonganoside D; Oblonganoside D CFN95460 943021-91-8 C41H64O12 = 749.0 5mg QQ客服：215959384
    Oblonganoside B; Oblonganoside B CFN91575 943021-89-4 C41H64O12 = 749.0 5mg QQ客服：1413575084
    3beta-Hydroxyurs-12,18-dien-28-oic acid beta-D-glucopyranosyl ester; 3beta-Hydroxyurs-12,18-dien-28-oic acid beta-D-glucopyranosyl ester CFN95461 434942-42-4 C36H56O8 = 616.8 5mg QQ客服：1413575084
    地榆皂苷II; Ziyuglycoside II CFN98465 35286-59-0 C35H56O8 = 604.8 20mg QQ客服：2056216494
    冬青苷D; Ilexoside D CFN90993 109008-27-7 C41H66O13 = 766.97 10mg QQ客服：1457312923
    枸骨叶皂甙I; Ilexside I CFN92273 83725-19-3 C41H66O13 = 472.7 5mg QQ客服：2056216494
    冬青苷K; Ilexoside K CFN90994 109008-26-6 C47H76O18 = 929.10 10mg QQ客服：2056216494
    28-O-beta-D-吡喃葡萄糖果树酸酯; Pomolic acid 28-O-beta-D-glucopyranosyl ester CFN97328 83725-24-0 C36H58O9 = 634.9 5mg QQ客服：1413575084

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