| Description: |
Ilexoside D has ant-allergic, and anti-coagulant activities, it shows anti-tissue factor activity as well as the antithrombotic activity. |
| In vitro: |
| Tetrahedron Letters, 1991, 32(29):3535-3538. | | Ilexosides A, B, C and D, anti-allergic 18,19-seco-ursane glycosides from fruit of Ilex crenata.[Reference: WebLink] |
METHODS AND RESULTS:
Four novel 18,19-seco-ursane glycosides named ilexoside A, ilexoside B, ilexoside C and Ilexoside D have been isolated from Ilex crenata Thunb.. Their structures were established as novel glycosides of 3β-hydroxy-19-oxo-18,19-seco-11,13(18)-ursadiene-28-oic-acid on the basis of chemical and spectroscopic analysis.
CONCLUSIONS:
They exhibited ant-allergic activities.The ant-alergic effect of Ilexoside A(1) ,ilexoside B(2) ,ilexoside C(3) and Ilexoside D(4) are 10 times as potent as glycyrrhizin. |
|
| In vivo: |
| Archives of Pharmacal Research, 1993, 16(3):209-212. | | Anticoagulant activity of ilexoside D, a triterpenoid saponin fromIlex pubescens.[Reference: WebLink] | The anti-coagulant activity of Ilexoside D isolated from the roots ofIlex pubescens Hook. et Arn. was investigated inin vivo andin vitro models of blood coagulation in rats.
METHODS AND RESULTS:
On oral administration, Ilexoside D prolonged the bleeding time and the whole blood recalcified clotting time, but not the plasma recalcified clotting time.In vitro, Ilexoside D did not affect the recalcified clotting times of whole blood, platelet-rich plasma (PRP), and platelet-poor plasma (PPP) while in the presence of tissue factor the compound prolonged the reduced prothrombin times of whole blood, PRP and PPP in the dose-dependent manner.
CONCLUSIONS:
These results indicate that Ilexoside D has the anti-tissue factor activity as well as the antithrombotic activity. |
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