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  • 酯蟾毒精

    Resibufagin

    酯蟾毒精
    产品编号 CFN91013
    CAS编号 20987-24-0
    分子式 = 分子量 C24H30O5 = 398.49
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The glandular body of Bufo bufo gargarizans Cantor.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    酯蟾毒精 CFN91013 20987-24-0 1mg QQ客服:2056216494
    酯蟾毒精 CFN91013 20987-24-0 5mg QQ客服:2056216494
    酯蟾毒精 CFN91013 20987-24-0 10mg QQ客服:2056216494
    酯蟾毒精 CFN91013 20987-24-0 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidad Industrial de Santander (Colombia)
  • University of Auckland (New Zealand)
  • The University of Newcastle (Australia)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • S.N.D.T. Women's University (India)
  • Sapienza University of Rome (Italy)
  • University of Ioannina (Greece)
  • Nanjing University of Chinese Medicine (China)
  • The Ohio State University (USA)
  • University of Zurich (Switzerland)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • Lodz University of Technology (Poland)
  • Chang Gung University (Taiwan)
  • University of Helsinki (Finland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food and Chemical Toxicology2020, 111221
  • Food and Agriculture Org. Of the UN2019, 151-160
  • Biomedicine & Pharmacotherapy2020, 125:109950
  • Journal of Oil Palm Research2019, 31(2):238-247
  • Evid Based Complement Alternat Med.2022, 2022:3483511
  • Biomed Pharmacother.2020, 128:110318.
  • Academic J of Second Military Medical University2018, 39(11)
  • Appl. Sci.2021, 11(19),9343.
  • BMC Complement Altern Med.2019, 19(1):325
  • Int J Mol Sci.2022, 23(10):5813.
  • Viruses.2021, 13(11):2118.
  • Institute of Food Science & Technology2021, 45(9).
  • Plants (Basel).2023, 12(22):3877.
  • Biol Pharm Bull.2018, 41(1):65-72
  • Heliyon.2023, 9(12):e22932.
  • Chemistry of Plant Materials.2016, 33-46
  • Int J Mol Sci.2021, 22(19):10220.
  • Sci Rep. 2018, 462(8)
  • Molecules.2020, 25(11):2599.
  • Front. Plant Sci.2022, 13:757852.
  • Horticulture Research2020, 7:111.
  • Neurotoxicology.2022, 91:218-227.
  • J of Dentistry & Oral Health2019, 2641-1962
  • ...
  • 生物活性
    Description: Resibufagin shows strong cytotoxic activity against HeLa cell line.
    In vitro:
    J Asian Nat Prod Res. 2008 Mar-Apr;10(3-4):233-7.
    One new bufadienolide from Chinese drug [Pubmed: 18335338 ]

    METHODS AND RESULTS:
    A new bufadienolide named 16beta-acetoxy-bufarenogin (1), together with six known bufadienolides, namely, 11alpha,12beta-dihydroxy-bufalin (2), bufotalin (3), hellebrigenin (4), desacetylbufotalin (5), gamabufotalin (6), and resibufagin (7) were isolated from Chan'Su. Of these, 2 was a new natural product. Their structures were elucidated by spectral methods.
    CONCLUSIONS:
    The cytotoxic activities in vitro of these compounds have been assayed against HeLa cell line. They all showed strong cytotoxic activities.
    In vivo:
    Zhongguo Zhong Yao Za Zhi. 2011 Nov;36(21):2987-93.
    Inhibitory effect of total bufadienolides from toad venom against H22 tumor in mice and their metabolites.[Pubmed: 22308689]
    To evaluate the inhibitory effect of total bufadienolides from toad venom against H22 tumor in mice and preliminarily analyze the structures of the metabolites in tissues.
    METHODS AND RESULTS:
    HPLC and LC-MS were used for analysis of the chemical composition of TBFs. High, middle and low dosages of TBFs were orally administered or intra-peritoneally injected to H22 tumor-bearing mice for thirteen days. The animals were killed and the tumors were stripped and weighed. The metabolites in the tissues such as heart, liver, spleen, lung and kidney, were analyzed by HPLC and LC-MS. The chemical composition of TBFs were identified by comparison of the retention times with those of reference substances, on-line UV spectra and MS data. Its main components are concerned with gamabufotalin, arenobufagin, bufotalin, Resibufagin, cinobufotalin, bufalin, cinobufagin and resibufogenin. TBFs had no obvious influence on body weight of H-22 tumor-bearing mice orally administered and the inhibition rate against tumor were 14.76%, 16.38% and 10.32% for low (5 mg x kg(-1)), middle (10 mg x kg(-1)) and high dosage (20 mg x kg(-1)), respectively. The mice intra-peritoneally injected with middle and high-dose of TBFs gained body weight slower than the control mice on the 5th day and recovered on the 13th day. The inhibition rate against tumor were 17.30%, 19.80% and 40.95% for low (1.5 mg x kg(-1)), middle (3 mg x kg(-1)) and high dose (6 mg x kg(-1)), respectively. The inhibitory effect took on dose-dependent manner. Based on the HPLC analyses on heart, liver, spleen, lung and kidney, bufadienolides were found in the liver tissue and 11 compounds of them were tentatively identified by LC-DAD-MS.
    CONCLUSIONS:
    TBFs by oral administration had no inhibitory effect against H22 tumor in mice, however, TBFs by intra-peritoneal injection displayed the significantly inhibitory effect, accompanying some toxicity for early duration of the study. The identification of bufadienolides in the liver provides a good basis for the further investigation of the metabolic pathways of TBFs in vivo.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5095 mL 12.5474 mL 25.0947 mL 50.1895 mL 62.7368 mL
    5 mM 0.5019 mL 2.5095 mL 5.0189 mL 10.0379 mL 12.5474 mL
    10 mM 0.2509 mL 1.2547 mL 2.5095 mL 5.0189 mL 6.2737 mL
    50 mM 0.0502 mL 0.2509 mL 0.5019 mL 1.0038 mL 1.2547 mL
    100 mM 0.0251 mL 0.1255 mL 0.2509 mL 0.5019 mL 0.6274 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    沙蟾毒精 3-辛二酸半酯; Arenobufagin 3-hemisuberate CFN90957 30219-16-0 C32H44O9 = 572.69 5mg QQ客服:1413575084
    原海葱甙A; Proscillaridin A CFN70368 466-06-8 C30H42O8 = 530.7 5mg QQ客服:2056216494
    19-羟基蟾毒灵; 19-Hydroxybufalin CFN91020 39844-86-5 C24H34O5 = 402.52 5mg QQ客服:1413575084
    远华蟾蜍精; Telocinobufagin CFN90213 472-26-4 C24H34O5 = 402.52 20mg QQ客服:2159513211
    嚏根草醇; Hellebrigenol CFN91021 508-79-2 C24H34O6 = 418.52 5mg QQ客服:215959384
    日本蟾蜍毒苷元; Gamabufotalin CFN90212 465-11-2 C24H34O5 = 402.52 20mg QQ客服:2056216494
    沙蟾毒精; Arenobufagin CFN98578 464-74-4 C24H32O6 = 416.51 20mg QQ客服:1413575084
    伪异沙蟾毒精; Bufarenogin CFN90151 17008-65-0 C24H32O6 = 416.51 5mg QQ客服:2159513211
    伪异沙蟾毒精; Pseudobufarenogin CFN91017 17008-69-4 C24H32O6 = 416.51 10mg QQ客服:215959384
    蟾毒它灵, 蟾蜍他灵; Bufotaline CFN98545 471-95-4 C26H36O6 = 444.56 20mg QQ客服:2056216494

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