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  • 南美蟾毒精

    Marinobufagenin

    南美蟾毒精
    产品编号 CFN93070
    CAS编号 470-42-8
    分子式 = 分子量 C24H32O5 = 400.51
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The glandular body of Bufo bufo gargarizans Cantor
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    南美蟾毒精 CFN93070 470-42-8 1mg QQ客服:2056216494
    南美蟾毒精 CFN93070 470-42-8 5mg QQ客服:2056216494
    南美蟾毒精 CFN93070 470-42-8 10mg QQ客服:2056216494
    南美蟾毒精 CFN93070 470-42-8 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Srinakharinwirot University (Thailand)
  • Aarhus University (Denmark)
  • Deutsches Krebsforschungszentrum (Germany)
  • Seoul National University of Science and Technology (Korea)
  • FORTH-IMBB (Greece)
  • University of Pretoria (South Africa)
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  • University of Illinois (USA)
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  • Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)
  • Kyushu University (Japan)
  • St. Jude Children Research Hospital (USA)
  • Institute of Chinese Materia Medica (China)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • JPC-Journal of Planar Chromatography 2017, 30(2)
  • Ann Transl Med.2019, 7(23):731
  • Manomaniam Sundaranar University2023, 3859769.
  • BMC Complement Altern Med.2019, 19(1):367
  • Life Sci.2023, 332:122107.
  • Phytomedicine.2018, 38:12-23
  • Chemistry of Plant Materials.2019, 215-222
  • J Chromatogr A.2022, 1685:463640.
  • J Phys Chem Lett.2021, 12(7):1793-1802.
  • Chemistry of Plant Materials.2016, 33-46
  • J.Acta Agriculturae Scandinavica2017, 571-575
  • Appl Microbiol Biotechnol.2016, 100(9):3965-77
  • Food and Chemical Toxicology2020, 111221
  • Food Chem X.2024, 21:101208.
  • Preprints2021, doi:10.20944
  • bioRxiv2021, 458409.
  • Research J. Pharm. and Tech.2020, 13(7):3059-3064.
  • J Chromatogr Sci.2020, 58(6):485-493.
  • Processes 2021, 9(5),894.
  • Molecules.2021, 26(9):2765.
  • Inflammation2015, 38(1):445-55
  • J Pharm Biomed Anal.2019, 164:119-127
  • Int J Mol Sci.2020, 21(8):2790.
  • ...
  • 生物活性
    Description: Marinobufagenin, a cardiotonic steroid, its increased concentrations are important in the cardiac disease and oxidant stress state seen with renal failure. Marinobufagenin is also an endogenous ligand of alpha-1 sodium pump, is a marker of congestive heart failure severity. Marinobufagenin stimulates fibroblast collagen production and causes fibrosis in experimental uremic cardiomyopathy. Marinobufagenin also can induce proliferation of human umbilical vein smooth muscle cells and a rat vascular smooth muscle cell line, A7r5.
    Targets: EGFR | ATPase
    In vitro:
    Hypertension. 2007 Jan;49(1):215-24.
    Marinobufagenin stimulates fibroblast collagen production and causes fibrosis in experimental uremic cardiomyopathy.[Pubmed: 17145984]
    We have observed recently that experimental renal failure in the rat is accompanied by increases in circulating concentrations of the cardiotonic steroid, Marinobufagenin (MBG), and substantial cardiac fibrosis. We performed the following studies to examine whether MBG might directly stimulate cardiac fibroblast collagen production.
    METHODS AND RESULTS:
    In vivo studies were performed using the 5/6th nephrectomy model of experimental renal failure (PNx), MBG infusion (MBG), PNx after immunization against MBG, and concomitant PNx and adrenalectomy. Physiological measurements with a Millar catheter and immunohistochemistry were performed. In vitro studies were then pursued with cultured isolated cardiac fibroblasts. We observed that PNx and MBG increased MBG levels, blood pressure, heart size, impaired diastolic function, and caused cardiac fibrosis. PNx after immunization against MBG and concomitant PNx and adrenalectomy had similar blood pressure as PNx but less cardiac hypertrophy, diastolic dysfunction, and cardiac fibrosis. MBG induced increases in procollagen-1 expression by cultured cardiac fibroblasts at 1 nM concentration. These increases in procollagen expression were accompanied by increases in collagen translation and increases in procollagen-1 mRNA without any demonstrable increase in procollagen-1 protein stability. The stimulation of fibroblasts with MBG could be prevented by administration of inhibitors of tyrosine phosphorylation, Src activation, epidermal growth factor receptor transactivation, and N-acetyl cysteine.
    CONCLUSIONS:
    Based on these findings, we propose that MBG directly induces increases in collagen expression by fibroblasts, and we suggest that this may be important in the cardiac fibrosis seen with experimental renal failure.
    In vivo:
    Hypertension. 2006 Mar;47(3):488-95.
    Central role for the cardiotonic steroid marinobufagenin in the pathogenesis of experimental uremic cardiomyopathy.[Pubmed: 16446397]
    Patients with chronic renal failure develop a "uremic" cardiomyopathy characterized by diastolic dysfunction, cardiac hypertrophy, and systemic oxidant stress. Patients with chronic renal failure are also known to have increases in the circulating concentrations of the cardiotonic steroid Marinobufagenin (MBG). On this background, we hypothesized that elevations in circulating MBG may be involved in the cardiomyopathy.
    METHODS AND RESULTS:
    First, we observed that administration of MBG (10 microg/kg per day) for 4 weeks caused comparable increases in plasma MBG as partial nephrectomy at 4 weeks. MBG infusion caused increases in conscious blood pressure, cardiac weight, and the time constant for left ventricular relaxation similar to partial nephrectomy. Decreases in the expression of the cardiac sarcoplasmic reticulum ATPase, cardiac fibrosis, and systemic oxidant stress were observed with both MBG infusion and partial nephrectomy. Next, rats were actively immunized against a MBG-BSA conjugate or BSA control, and partial nephrectomy was subsequently performed. Immunization against MBG attenuated the cardiac hypertrophy, impairment of diastolic function, cardiac fibrosis, and systemic oxidant stress seen with partial nephrectomy without a significant effect on conscious blood pressure.
    CONCLUSIONS:
    These data suggest that the increased concentrations of MBG are important in the cardiac disease and oxidant stress state seen with renal failure.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4968 mL 12.4841 mL 24.9682 mL 49.9363 mL 62.4204 mL
    5 mM 0.4994 mL 2.4968 mL 4.9936 mL 9.9873 mL 12.4841 mL
    10 mM 0.2497 mL 1.2484 mL 2.4968 mL 4.9936 mL 6.242 mL
    50 mM 0.0499 mL 0.2497 mL 0.4994 mL 0.9987 mL 1.2484 mL
    100 mM 0.025 mL 0.1248 mL 0.2497 mL 0.4994 mL 0.6242 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    远华蟾蜍精; Telocinobufagin CFN90213 472-26-4 C24H34O5 = 402.52 20mg QQ客服:1413575084
    嚏根草醇; Hellebrigenol CFN91021 508-79-2 C24H34O6 = 418.52 5mg QQ客服:1413575084
    日本蟾蜍毒苷元; Gamabufotalin CFN90212 465-11-2 C24H34O5 = 402.52 20mg QQ客服:1457312923
    沙蟾毒精; Arenobufagin CFN98578 464-74-4 C24H32O6 = 416.51 20mg QQ客服:1413575084
    伪异沙蟾毒精; Bufarenogin CFN90151 17008-65-0 C24H32O6 = 416.51 5mg QQ客服:1413575084
    伪异沙蟾毒精; Pseudobufarenogin CFN91017 17008-69-4 C24H32O6 = 416.51 10mg QQ客服:215959384
    蟾毒它灵, 蟾蜍他灵; Bufotaline CFN98545 471-95-4 C26H36O6 = 444.56 20mg QQ客服:1457312923
    酯蟾毒配基,蟾力苏; Resibufogenin CFN98543 465-39-4 C24H32O4 = 384.51 20mg QQ客服:1457312923
    酯蟾毒精; Resibufagin CFN91013 20987-24-0 C24H30O5 = 398.49 5mg QQ客服:2159513211
    去乙酰华蟾毒精; Deacetylcinobufagin CFN90579 4026-95-3 C24H32O5 = 400.52 10mg QQ客服:2159513211

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