地黄苦苷元

Rehmapicrogenin

	产品编号	CFN91691
	CAS编号	135447-39-1
	分子式 = 分子量	C₁₀H₁₆O₃ = 184.2
	产品纯度	>=98%
	物理属性	Oil
	化合物类型	Monoterpenoids
	植物来源	The roots of Rehmannia glutinosa
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产品名称	产品编号	CAS编号	包装	QQ客服
地黄苦苷元	CFN91691	135447-39-1	1mg	QQ客服：3257982914
地黄苦苷元	CFN91691	135447-39-1	5mg	QQ客服：3257982914
地黄苦苷元	CFN91691	135447-39-1	10mg	QQ客服：3257982914
地黄苦苷元	CFN91691	135447-39-1	20mg	QQ客服：3257982914

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Description:

Rehmapicrogenin, isolated from the root of Rehmannia glutinosa, exhibits potent anti-inflammatory effect by inhibiting iNOS, COX-2 and IL-6. Rehmapicrogenin attenuates kidney damage by reducing inflammatory factor release through the oestrogen signalling pathway.

In vitro:

J Ethnopharmacol . 2012 Oct 11;143(3):867-875.

Bioassay-guided isolation of anti-inflammatory components from the root of Rehmannia glutinosa and its underlying mechanism via inhibition of iNOS pathway[Pubmed: 23034094]

Ethnopharmacological relevance: The root of Rehmannia glutinosa (RR) is commonly used to reduce inflammation in various traditional Chinese herbal formulae; however, little is known regarding its active component(s). Aim of study: The objective of the present study was to examine the active component(s) responsible for the anti-inflammatory activity of RR via anti-nitric oxide production assay-guided fractionation; and the underlying anti-inflammatory mechanism of action of such component(s) was further investigated. Materials and methods: Anti-nitric oxide (NO) activities with lipopolysaccharides (LPS)-stimulated RAW264.7 murine macrophages was used as screening platform. Gene, protein and inflammatory mediators' expression were also studied using real-time PCR, western blotting and ELISA, respectively. Results: Using anti-NO assay-guided fractionation, sub-fraction C3 (from 31.25 to 62.5 μg/ml, p=0.001 to 0.01) possessed 100-fold more potent anti-inflammatory effect than that of the aqueous extract of RR. Characterization of C3 showed that the anti-inflammatory effect could be partly due to the presence of rehmapicrogenin, which could significantly inhibit NO production (p<0.001). C3 was further demonstrated in blocking inflammation by inhibiting gene (p<0.001) and protein expression of inducible NO synthase (iNOS) dose-dependently. Besides, C3 also significantly inhibited the production of prostaglandin E(2) (p<0.001 to 0.01), IL-6 (p<0.001 to 0.05) and COX-2 (p<0.05). Conclusions: Rehmapicrogenin was, for the first time, shown to possess nitric oxide inhibitory activities. Bioassay-guided fractionation demonstrated that rehmapicrogenin-containing subfraction C3 exhibited potent anti-inflammatory effect by inhibiting iNOS, COX-2 and IL-6, while rehmapicrogenin was only partially responsible for the anti-inflammatory effect of RR.

In vivo:

Zhongguo Zhong Yao Za Zhi . 2021 May;46(9):2287-2297.

[Analysis of blood components of Yougui Yin in normal rats and rats with kidney deficiency caused by adenine based on UPLC-MS technology][Pubmed: 34047132]

Based on the serum medicinal method, this study aims to investigate the migrating components of Yougui Yin in the blood after intragastric administration, and to provide reference for the basic research of its pharmacodynamics. The kidney deficiency rat model was replicated by adenine method. Normal rats and model rats were administered orally for a single gavage of Yougui Yin. The components in blood were rapidly analyzed and identified by ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry(UPLC-Q-TOF-MS) and multiple reaction monitoring(MRM), and the migrating components in blood of Yougui Yin were explored by multivariate statistical analysis. The results showed that there were 42 characteristic peaks in the plasma of normal rats by UPLC-Q-TOF-MS technology and 13 chemical components were identified, including 6 alkaloids, 2 flavonoids, 2 triterpenoid saponins, 1 iridoid, 1 phenylpropanoid and 1 monoterpenoid. There were 22 characteristic peaks in the plasma of kidney-deficiency rats, and 12 chemical components were identified, including 2 iridoids, 6 alkaloids, 2 flavonoids, 1 monoterpenoid and 1 triterpenoid saponin. Verbascoside, isoacteoside, acteoside, pinoresinoldiglucoside, loganin and morroniside were identified by MRM both in the plasma of normal rats and kidney-deficiency rats. Compared with 85 monomer components in Yougui Yin, 17 common prototype components were found by UPLC-MS in the plasma of normal rats and kidney deficiency rats, including verbascoside, isoacteoside, acteoside, rehmapicrogenin derived from Rehmanniae Radix Praeparata, pinoresinol diglucoside and geniposidic acid from Eucommiea Cortex, loganin and morroniside derived from Corni Fructus, mesaconine, benzoylmesaconine, benzoylaconitine, benzoylhypacoitine, mesaconitine, aconitine derived from Aconiti Lateralis Radix Praeparata, liquiritin, isoliquiritin and glycyrrhizic acid derived from Glycyrrhizae Radix et Rhizoma. Thirty-one metabolites of medicinal ingredients not found in the plasma of adenine-induced kidney deficiency rats were also detected in the plasma of normal rats. Twelve metabolites of medicinal materials not found in the plasma of normal rats were detected in the plasma of kidney deficiency rats. The results of the study provide reference for explaining the material basis and mechanism of Yougui Yin in the treatment of kidney deficiency.

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	5.4289 mL	27.1444 mL	54.2888 mL	108.5776 mL	135.722 mL
5 mM	1.0858 mL	5.4289 mL	10.8578 mL	21.7155 mL	27.1444 mL
10 mM	0.5429 mL	2.7144 mL	5.4289 mL	10.8578 mL	13.5722 mL
50 mM	0.1086 mL	0.5429 mL	1.0858 mL	2.1716 mL	2.7144 mL
100 mM	0.0543 mL	0.2714 mL	0.5429 mL	1.0858 mL	1.3572 mL

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
地芰普内酯; Loliolid	CFN92750	5989-02-6	C₁₁H₁₆O₃ = 196.2	5mg	QQ客服：1457312923
异地芰普内酯; Isololiolide	CFN95106	38274-00-9	C₁₁H₁₆O₃ = 196.2	5mg	QQ客服：2056216494
4-羟基-2,6,6-三甲基-1-环己烯羧酸; 4-Hydroxy-2,6,6-trimethyl-1-cyclohexenecarboxylic acid	CFN97070	62218-55-7	C₁₀H₁₆O₃ = 184.2	5mg	QQ客服：2056216494
地黄苦苷元; Rehmapicrogenin	CFN91691	135447-39-1	C₁₀H₁₆O₃ = 184.2	5mg	QQ客服：3257982914
地黄苦苷; Rehmapicroside	CFN90760	104056-82-8	C₁₆H₂₆O₈ = 346.4	5mg	QQ客服：1457312923
苦番红花素; Picrocrocin	CFN91177	138-55-6	C₁₆H₂₆O₇ = 330.4	20mg	QQ客服：2159513211
β-蒎烯; Beta-pinene	CFN93287	18172-67-3	C₁₀H₁₆ = 136.2	20mg	QQ客服：1457312923
α-蒎烯; Alpha-pinene	CFN93285	80-56-8	C₁₀H₁₆ = 136.2	20mg	QQ客服：2056216494

地黄苦苷元

Rehmapicrogenin

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