α-蒎烯

Alpha-pinene

	产品编号	CFN93285
	CAS编号	80-56-8
	分子式 = 分子量	C₁₀H₁₆ = 136.2
	产品纯度	>=98%
	物理属性	Oil
	化合物类型	Monoterpenoids
	植物来源	The heartwoods of Pinus armandii Franch.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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α-蒎烯	CFN93285	80-56-8	10mg	QQ客服：215959384
α-蒎烯	CFN93285	80-56-8	20mg	QQ客服：215959384
α-蒎烯	CFN93285	80-56-8	50mg	QQ客服：215959384
α-蒎烯	CFN93285	80-56-8	100mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Virginia (USA)

Stanford University (USA)

Mendel University in Brno (Czech Republic)

S.N.D.T. Women's University (India)

University of Minnesota (USA)

Osmania University (India)

Uniwersytet Medyczny w ?odzi (Poland)

Max-Planck-Insitut (Germany)

Universiti Sains Malaysia (Malaysia)

University of Bordeaux (France)

Chungnam National University (Korea)

Medical University of South Carolina (USA)

Srinakharinwirot University (Thailand)

University of Bonn (Germany)

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Description:

Alpha-pinene inhibits the nuclear translocation of NF-kappa B induced by LPS in THP-1 cells, and this effect is partly due to the upregulation of I kappa B alpha expression. Alpha-pinene inhibits early root growth and causes oxidative damage in root tissue through enhanced generation of ROS, as indicated by increased lipid peroxidation, disruption of membrane integrity and elevated antioxidant enzyme levels.

Targets:

NF-kB | p65 | ROS

In vitro:

Acta Pharmacol Sin. 2004 Apr;25(4):480-4.

Effect of alpha-pinene on nuclear translocation of NF-kappa B in THP-1 cells.[Pubmed: 15066217]

METHODS AND RESULTS:
To study the effects of Alpha-pinene on nuclear translocation of nuclear factor-kappa B (NF-kappa B) and the expression of the inhibitThe majority of FITC-labelled NF-kappa B/p65 was located in the nuclei being stimulated with LPS. Whereas, no such fluorescence was seen in the nuclei of the groups pretreated with Alpha-pinene or control cells. Alpha-pinene pretreatment decreased the NF-kappa B/p65 nuclear translocation in LPS-stimulated THP-1 cells, and this effect was dose-dependent, but there was no reaction in LPS-unstimulated THP-1 cells. Alpha-pinene pretreatment increased I kappa B alpha protein level in cytoplasm, compared with that in LPS-stimulated THP-1 cells.
CONCLUSIONS:
In a dose-related fashion, Alpha-pinene inhibits the nuclear translocation of NF-kappa B induced by LPS in THP-1 cells, and this effect is partly due to the upregulation of I kappa B alpha expression.or of NF-kappa B (I kappa B alpha) in human monocyte THP-1 cell line.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
地芰普内酯; Loliolid	CFN92750	5989-02-6	C₁₁H₁₆O₃ = 196.2	5mg	QQ客服：1413575084
异地芰普内酯; Isololiolide	CFN95106	38274-00-9	C₁₁H₁₆O₃ = 196.2	5mg	QQ客服：2159513211
4-羟基-2,6,6-三甲基-1-环己烯羧酸; 4-Hydroxy-2,6,6-trimethyl-1-cyclohexenecarboxylic acid	CFN97070	62218-55-7	C₁₀H₁₆O₃ = 184.2	5mg	QQ客服：215959384
地黄苦苷元; Rehmapicrogenin	CFN91691	135447-39-1	C₁₀H₁₆O₃ = 184.2	5mg	QQ客服：3257982914
地黄苦苷; Rehmapicroside	CFN90760	104056-82-8	C₁₆H₂₆O₈ = 346.4	5mg	QQ客服：2056216494
苦番红花素; Picrocrocin	CFN91177	138-55-6	C₁₆H₂₆O₇ = 330.4	20mg	QQ客服：215959384
β-蒎烯; Beta-pinene	CFN93287	18172-67-3	C₁₀H₁₆ = 136.2	20mg	QQ客服：3257982914
α-蒎烯; Alpha-pinene	CFN93285	80-56-8	C₁₀H₁₆ = 136.2	20mg	QQ客服：215959384

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	7.3421 mL	36.7107 mL	73.4214 mL	146.8429 mL	183.5536 mL
5 mM	1.4684 mL	7.3421 mL	14.6843 mL	29.3686 mL	36.7107 mL
10 mM	0.7342 mL	3.6711 mL	7.3421 mL	14.6843 mL	18.3554 mL
50 mM	0.1468 mL	0.7342 mL	1.4684 mL	2.9369 mL	3.6711 mL
100 mM	0.0734 mL	0.3671 mL	0.7342 mL	1.4684 mL	1.8355 mL