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  • 岩茨烯A

    • 岩茨烯A

    Rehmannic acid

    岩茨烯A
    		产品编号 CFN97738
    CAS编号 467-81-2
    分子式 = 分子量 C35H52O5 = 552.80
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The herbs of Lantana camara
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    岩茨烯A CFN97738 467-81-2 1mg QQ客服：1413575084
    岩茨烯A CFN97738 467-81-2 5mg QQ客服：1413575084
    岩茨烯A CFN97738 467-81-2 10mg QQ客服：1413575084
    岩茨烯A CFN97738 467-81-2 20mg QQ客服：1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Biofactors.2018, 44(2):168-179
  • Molecules.2021, 26(23):7390.
  • J Ethnopharmacol.2024, 324:117775.
  • Food Chem.2022, 373(Pt B):131364.
  • Natural Product Res.&Deve.2022, 1001-6880.
  • Earth Environ. Sci. 2021, 905:012080.
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  • Int J Mol Sci.2020, 21(22):8816.
  • Chem Biol Interact.2022, 368:110248.
  • Indian J Pharm Sci.2022, 84(4): 874-882.
  • Food Chem.2017, 221:1135-1144
  • Int Immunopharmacol.2021, 101(Pt A):108181.
  • Chinese Pharmacological Bulletin2019, 35(8):1120-1125
  • Phytochem Anal.2021, 32(6):970-981.
  • Int. J. of Pha. and Phy. Res.2015, 7(1):144-149
  • University of Limpopo2016, 1-237
  • Pharmaceuticals (Basel).2024 Feb 24;17(3):292.
  • J Agric Food Chem.2015, 63(44):9869-78
  • FEMS Microbiol Lett.2017, 364(11)
  • Front Pharmacol.2018, 9:756
  • Plants (Basel).2023, 12(5):1120.
  • ...
    • 生物活性
    Description: Rehmannic acid and oleanolic acetate inhibit succinoxidase activity. Both Rehmannic acid and Icterogenin are potent uncouplers, abolishing the phosphate uptake, the respiration being inhibited by the former and increased by the latter.
    Targets: NADPH-oxidase
    In vivo:
    Biochemical Pharmacology.1968 Jun;17(6):1079–1089.
    Inhibition of biliary secretion by icterogenin and related triterpenes-I. Effect of icterogenin, rehmannic acid and oleanolic acetate on liver mitochondria in vitro.[Reference: WebLink]
    The effect of Icterogenin, Rehmannic acid and oleanolic acetate on respiration, mitochondrial structure and oxidative phosphorylation in rabbit and rat liver mitochondria was studied.
    METHODS AND RESULTS:
    All three substances at a concentration 1 × 1o−4 M and 5 × 10−5M inhibit the respiration of NAD-linked enzymes. Only Icterogenin in the concentration 1 × 10−5 M increased the respiration rate. The succinoxidase activity was inhibited by Rehmannic acid and oleanolic acetate. Icterogenin at the concentrations 1 × 10−4 M and 5 × 10−5 M did not cause any definite changes in respiration with succinate as substrate, but at the concentration 1 × 10-5 M the respiration was always increased.The substances were found to increase the mitochondrial membrane permeability and Icterogenin had a swelling effect of the large amplitude type. The oxidative phosphorylation was uncoupled by Icterogenin and Rehmannic acid and inhibited by oleanolic acetate. Rehmannic acid at a concentration 5 × 10−5 M almost completely abolished the phosphate uptake when glutamate was used as substrate. The effect of Icterogenin was less. The respiration with glutamate as substrate was inhibited 50 per cent by the former and to about 25 per cent by the latter.
    CONCLUSIONS:
    With succinate as substrate, both Rehmannic acid and Icterogenin were potent uncouplers, abolishing the phosphate uptake, the respiration being inhibited by the former and increased by the latter. The connection between chemical structure and effect on oxidative phosphorylation is discussed.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.809 mL 9.0449 mL 18.0897 mL 36.1795 mL 45.2243 mL
    5 mM 0.3618 mL 1.809 mL 3.6179 mL 7.2359 mL 9.0449 mL
    10 mM 0.1809 mL 0.9045 mL 1.809 mL 3.6179 mL 4.5224 mL
    50 mM 0.0362 mL 0.1809 mL 0.3618 mL 0.7236 mL 0.9045 mL
    100 mM 0.0181 mL 0.0904 mL 0.1809 mL 0.3618 mL 0.4522 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    黄莲木酸; Moronic acid CFN97145 6713-27-5 C30H46O3 = 454.7 5mg QQ客服：1457312923
    Pyrocincholic acid methyl ester; Pyrocincholic acid methyl ester CFN99079 107160-24-7 C30H48O3 = 456.7 5mg QQ客服：3257982914
    苦杏酸; Camaric acid CFN99606 146450-83-1 C35H52O6 = 568.8 5mg QQ客服：215959384
    岩茨烯A; Rehmannic acid CFN97738 467-81-2 C35H52O5 = 552.80 5mg QQ客服：1457312923
    Melliferone; Melliferone CFN95709 377724-68-0 C30H44O3 = 452.7 5mg QQ客服：2159513211
    路路通内酯; Liquidambaric lactone CFN90155 185051-75-6 C30H44O4 = 468.67 5mg QQ客服：3257982914
    3beta-乙酰氧基-11alpha,12alpha-环氧齐墩果烷-13beta,28-内酯; 3beta-Acetoxy-11alpha,12alpha-epoxyoleanan-28,13beta-olide CFN96374 35738-25-1 C32H48O5 = 512.7 5mg QQ客服：1413575084
    16-脱氧柴胡甙元 F; 16-Deoxysaikogenin F CFN96265 57475-62-4 C30H48O3 = 456.7 5mg QQ客服：2159513211
    11alpha,12alpha-Epoxy-3beta,23-dihydroxy-30-norolean-20(29)-en-28,13beta-olide ; 11alpha,12alpha-Epoxy-3beta,23-dihydroxy-30-norolean-20(29)-en-28,13beta-olide CFN96095 186140-36-3 C29H42O5 = 470.7 5mg QQ客服：1457312923
    3-O-Acetyloleanderolide; 3-O-Acetyloleanderolide CFN97080 62498-83-3 C32H50O5 = 514.8 5mg QQ客服：1457312923

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