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  • 槲皮万寿菊素

    • 槲皮万寿菊素

    Quercetagetin

    槲皮万寿菊素
    		产品编号 CFN93336
    CAS编号 90-18-6
    分子式 = 分子量 C15H10O8 = 318.23
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Tagetes erecta L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    槲皮万寿菊素 CFN93336 90-18-6 10mg QQ客服：2056216494
    槲皮万寿菊素 CFN93336 90-18-6 20mg QQ客服：2056216494
    槲皮万寿菊素 CFN93336 90-18-6 50mg QQ客服：2056216494
    槲皮万寿菊素 CFN93336 90-18-6 100mg QQ客服：2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • Medical University of South Carolina (USA)
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Trop J Nat Prod Res.2019, 3(1):6-9
  • Processes2020, 8(12),1540.
  • Molecules.2018, 23(12):E3103
  • Processes2023, 11(2), 385。
  • Natural Product Communications2020, doi: 10.1177.
  • Anticancer Res.2020, 40(10):5529-5538.
  • J Ginseng Res.2023, 47(4):572-582.
  • J Nat Prod.2019, 82(4):1002-1008
  • Int J Mol Sci.2020, 21(8):2790.
  • Kyung Hee University2024, rs-3888374
  • Fitoterapia.2018, 124:92-102
  • Int J Mol Sci.2021, 22(10):5181.
  • J Ethnopharmacol.2024, 318:116863.
  • BMB Rep.2020, 53(4):218-222.
  • J Chem Inf Model.2021, 61(11):5708-5718.
  • Hum Exp Toxicol.2017, 36(11):1169-1176
  • Indian J. of Experimental Bio.2020, 9(58).
  • Pharmaceuticals (Basel).2020, 13(9):262.
  • J of Applied Biological Chem.2020, 63(2):147-152
  • Cell Mol Biol (Noisy-le-grand).2023, 69(15):167-173.
  • Nat Prod Commun.2014, 9(5):679-82
  • Int J Mol Sci.2018, 19(9):E2825
  • Environ Toxicol.2020, doi: 10.1002
  • ...
    • 生物活性
    Description: Quercetagetin may be a potent inhibitor of the STAT1 signal, which could be a new molecular target for anti-inflammatory treatment, and may thus have therapeutic applications as an immune modulator in inflammatory diseases such as AD. It has stronger inhibitory effects on the protein and mRNA expression of TARC and MDC than other flavonoids.
    Targets: TARC | MDC | STAT
    In vitro:
    Biomolecules and Therapeutics, 2013, 21(2):138-145.
    Anti-Inflammatory Effect of Quercetagetin, an Active Component of Immature Citrus unshiu, in HaCaT Human Keratinocytes.[Pubmed: 24009872 ]
    Citrus fruit contain various flavonoids that have multiple biological activities. However, the content of these flavonoids are changed during maturation and immature Citrus is known to contain larger amounts than mature. Chemokines are significant mediators for cell migration, while thymus and activation-regulated chemokine (TARC/CCL17) and macrophage-derived chemokine (MDC/CCL22) are well known as the typical inflammatory chemokines in atopic dermatitis (AD), a pruritic and chronic inflammatory skin disease. We reported recently that the EtOH extract of immature Citrus unshiu inhibits TARC and MDC production.
    METHODS AND RESULTS:
    Therefore, we investigated the activity of flavonoids contained in immature Citrus on TARC and MDC levels. As a result, among the various flavonoids, quercetagetin has stronger inhibitory effects on the protein and mRNA expression of TARC and MDC than other flavonoids. Quercetagetin particularly has better activity on TARC and MDC level than quercetin. In HPLC analysis, the standard peak of quercetagetin matches the peaks of extract of immature C. unshiu.
    CONCLUSIONS:
    This suggests that quercetagetin is an anti-inflammatory component in immature C. unshiu.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.1424 mL 15.7119 mL 31.4238 mL 62.8476 mL 78.5595 mL
    5 mM 0.6285 mL 3.1424 mL 6.2848 mL 12.5695 mL 15.7119 mL
    10 mM 0.3142 mL 1.5712 mL 3.1424 mL 6.2848 mL 7.856 mL
    50 mM 0.0628 mL 0.3142 mL 0.6285 mL 1.257 mL 1.5712 mL
    100 mM 0.0314 mL 0.1571 mL 0.3142 mL 0.6285 mL 0.7856 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    4',5,7-三羟基 3,3',6,8-四甲氧基黄酮 ; 4',5,7-Trihydroxy 3,3',6,8-tetramethoxyflavone CFN70415 58130-91-9 C19H18O9 = 390.3 5mg QQ客服：1413575084
    3',4',7,8-四甲氧基黄酮; 3',4',7,8-Tetramethoxyflavone CFN70432 65548-55-2 C19H18O6 = 342.4 20mg QQ客服：3257982914
    4'-羟基-6,7,8,3'-四甲氧基黄酮醇; 4'-hydroxy-6,7,8,3'-tetramethoxyflavonol CFN91846 1879030-01-9 C19H18O8 = 374.4 5mg QQ客服：2056216494
    5,7,3',4'-四甲氧基黄酮; 5,7,3',4'-Tetramethoxyflavone CFN91116 855-97-0 C19H18O6 = 342.3 20mg QQ客服：2159513211
    栎精-3,7,3’,4’-四甲醚; Retusin CFN89520 1245-15-4 C19H18O7 = 358.34 10mg QQ客服：2056216494
    槲皮素3,5,7,3',4'-五甲基醚; Quercetin 3,5,7,3,4-pentamethyl ether CFN70262 1247-97-8 C20H20O7 = 372.4 5mg QQ客服：2056216494
    艾黄素; Artemetin CFN98731 479-90-3 C20H20O8 = 388.4 20mg QQ客服：2159513211
    乙酰艾黄素; 乙酸六棱菊亭酯; Artemetin acetate CFN97530 95135-98-1 C22H22O9 = 430.4 5mg QQ客服：2056216494
    槲皮素; Quercetin CFN99272 117-39-5 C15H10O7 = 302.2 20mg QQ客服：215959384
    杜鹃黄素; Azaleatin CFN91007 529-51-1 C16H12O7 = 316.3 10mg QQ客服：3257982914

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