Info: Read More
  • 中药标准品生产商,产品定制服务
  • 蕨素 B

    Pterosin B

    蕨素 B
    产品编号 CFN96798
    CAS编号 34175-96-7
    分子式 = 分子量 C14H18O2 = 218.29
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The aerial parts of Pteris semipinnata.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    蕨素 B CFN96798 34175-96-7 1mg QQ客服:1413575084
    蕨素 B CFN96798 34175-96-7 5mg QQ客服:1413575084
    蕨素 B CFN96798 34175-96-7 10mg QQ客服:1413575084
    蕨素 B CFN96798 34175-96-7 20mg QQ客服:1413575084
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Ioannina (Greece)
  • Istanbul University (Turkey)
  • Universidad Miguel Hernández (Spain)
  • Florida International University (USA)
  • Warszawski Uniwersytet Medyczny (Poland)
  • University of Padjajaran (Indonesia)
  • MTT Agrifood Research Finland (Finland)
  • University of Parma (Italy)
  • Medical University of South Carolina (USA)
  • Regional Crop Research Institute (Korea)
  • University of Maryland (USA)
  • Utrecht University (Netherlands)
  • Charles University in Prague (Czech Republic)
  • Weizmann Institute of Science (Israel)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Biomed Sci.2020, 27(1):60.
  • J Formos Med Assoc.2020, S0929-6646(20)30425-3
  • J Pharm Biomed Anal.2019, 172:268-277
  • Viruses.2021, 13(11):2118.
  • Horticulturae2020, 6(4),76.
  • J Ethnopharmacol.2021, 267:113615.
  • Phytochemistry Letters2015, 243-247
  • J Cell Physiol.2020, 10.1002
  • Processes2021, 9(1), 153;
  • Journal of Molecular Liquids2022, 364:120062.
  • LWT2020, 126:109313
  • Analytical sci. & Tech2020, 33(5):224-231
  • Korean J of Crop Science2019, 452-458
  • Int J Mol Sci.2021, 22(10):5181.
  • Korean Journal of Pharmacognosy2017, 48(4):320-328
  • Biochem Biophys Res Commun.2020, 527(4):889-895.
  • Int J Mol Sci.2021, 22(17):9400.
  • J Cell Mol Med.2023, 27(10):1423-1435.
  • Front Chem.2023, 11:1245071.
  • Res Rep Urol.2022, 14:313-326.
  • J Korean Soc Food Sci Nutr2023, 52(11):1101-1110
  • J of the Society of Cosmetic Scientists of Korea2018, 44(4):407-417
  • Chemistry of Plant Materials.2019, 129-136
  • ...
  • 生物活性
    Description: Pterosin B is a salt-inducible kinase 3 (Sik3) pathway inhibitor, it prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3. Pterosin B shows cytotoxicity against HL 60 cells (human leukemia) with the IC(50) value of 8.7 microg/mL. Pterosin B has multiple targets in gluconeogenic programs, including coenzyme Q in RORα-SRC2 signaling.
    Targets: cAMP | AMPK
    In vivo:
    Nat Commun. 2016 Mar 24;7:10959.
    Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3.[Pubmed: 27009967]
    Osteoarthritis is a common debilitating joint disorder. Risk factors for osteoarthritis include age, which is associated with thinning of articular cartilage.
    METHODS AND RESULTS:
    Here we generate chondrocyte-specific salt-inducible kinase 3 (Sik3) conditional knockout mice that are resistant to osteoarthritis with thickened articular cartilage owing to a larger chondrocyte population. We also identify an edible Pteridium aquilinum compound, pterosin B, as a Sik3 pathway inhibitor. We show that either Sik3 deletion or intraarticular injection of mice with pterosin B inhibits chondrocyte hypertrophy and protects cartilage from osteoarthritis.
    CONCLUSIONS:
    Collectively, our results suggest Sik3 regulates the homeostasis of articular cartilage and is a target for the treatment of osteoarthritis, with pterosin B as a candidate therapeutic.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.5811 mL 22.9053 mL 45.8106 mL 91.6212 mL 114.5265 mL
    5 mM 0.9162 mL 4.5811 mL 9.1621 mL 18.3242 mL 22.9053 mL
    10 mM 0.4581 mL 2.2905 mL 4.5811 mL 9.1621 mL 11.4527 mL
    50 mM 0.0916 mL 0.4581 mL 0.9162 mL 1.8324 mL 2.2905 mL
    100 mM 0.0458 mL 0.2291 mL 0.4581 mL 0.9162 mL 1.1453 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    表蕨素L 2'-O-葡萄糖苷; Epipterosin L 2'-O-glucoside CFN97719 61117-89-3 C21H30O9 = 426.46 5mg QQ客服:3257982914
    (2R)-去甲蕨素 B; Norpterosin B CFN96799 1226892-20-1 C13H16O2 = 204.26 5mg QQ客服:3257982914
    去甲蕨素 B 葡萄糖苷; Norpterosin B glucoside CFN89000 1226785-88-1 C19H26O7 = 366.41 5mg QQ客服:2056216494
    蕨素 B ; Pterosin B CFN96798 34175-96-7 C14H18O2 = 218.29 5mg QQ客服:2056216494
    反式-去甲蕨素 C ; trans-Norpterosin C CFN96609 64890-70-6 C13H16O3 = 220.27 5mg QQ客服:1457312923
    蕨素 C; Pterosin C CFN96802 35938-43-3 C14H18O3 = 234.29 5mg QQ客服:2056216494
    蕨素G; Pterosin G CFN80185 35964-50-2 C14H18O3 = 234.12 5mg QQ客服:215959384
    金粉蕨亭2'-O-葡萄糖苷; Onitin 2'-O-glucoside CFN97251 76947-60-9 C21H30O8 = 410.5 5mg QQ客服:1457312923
    金粉蕨辛; Onitisin CFN98899 53823-03-3 C15H20O4 = 264.3 5mg QQ客服:2159513211
    金粉蕨辛2'-O-葡萄糖苷; Onitisin 2'-O-glucoside CFN97066 62043-53-2 C21H30O9 = 426.5 5mg QQ客服:2159513211

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产