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  • 蕨素A

    Pterosin A

    蕨素A
    产品编号 CFN80051
    CAS编号 35910-16-8
    分子式 = 分子量 C15H20O3 = 248.14
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The herbs of Pteris aquilinum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    蕨素A CFN80051 35910-16-8 1mg QQ客服:1413575084
    蕨素A CFN80051 35910-16-8 5mg QQ客服:1413575084
    蕨素A CFN80051 35910-16-8 10mg QQ客服:1413575084
    蕨素A CFN80051 35910-16-8 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

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    IF=12.804(2019)

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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pharmaceutics.2022, 14(12):2765.
  • Journal of Life Science2017, 233-240
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  • Russian J Bioorganic Chemistry 2021, 47:1411-1417.
  • Nutrients2023, 15(18), 4016.
  • Environ Toxicol.2021, doi: 10.1002
  • J of Pharmaceutical Analysis2020, doi: 10.1016
  • Antioxidants (Basel).2019, 8(8):E307
  • Food Chem.2020, 327:126992.
  • Molecules.2018, 23(7):E1659
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  • Thorac Cancer.2023, 14(21):2007-2017.
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  • ...
  • 生物活性
    Description: Pterosin A is a novel activator of adenosine monophosphate-activated protein kinase, which is crucial for regulating blood glucose homeostasis. Pterosin A has potential anti-diabetic activity, it can significantly reverse the increased serum insulin and insulin resistance (IR) in dexamethasone-IR mice and in db/db mice.
    Targets: ROS | GLUT | AMPK | Akt | p38MAPK | GSK-3
    In vitro:
    Int J Mol Sci. 2015 Jan 22;16(2):2497-516.
    Chemical constituents analysis and antidiabetic activity validation of four fern species from Taiwan.[Pubmed: 25622260]
    Pterosins are abundant in ferns, and Pterosin A was considered a novel activator of adenosine monophosphate-activated protein kinase, which is crucial for regulating blood glucose homeostasis. However, the distribution of pterosins in different species of ferns from various places in Taiwan is currently unclear.
    METHODS AND RESULTS:
    To address this question, the distribution of pterosins, glucose-uptake efficiency, and protective effects of Pterosin A on β-cells were examined. Our results showed that three novel compounds, 13-chloro-spelosin 3-O-β-d-glucopyranoside (1), (3R)-Pterosin D 3-O-β-d-(3'-p-coumaroyl)-glucopyranoside (2), and (2R,3R)-Pterosin L 3-O-β-d-(3'-p-coumaroyl)-glucopyranoside (3), were isolated for the first time from four fern species (Ceratopteris thalictroides, Hypolepis punctata, Nephrolepis multiflora, and Pteridium revolutum) along with 27 known compounds. We also examined the distribution of these pterosin compounds in the mentioned fern species (except N. multiflora). Although all Pterosin Analogs exhibited the same effects in glucose uptake assays, Pterosin A prevented cell death and reduced reactive oxygen species (ROS) production.
    CONCLUSIONS:
    This paper is the first report to provide new insights into the distribution of pterosins in ferns from Taiwan. The potential anti-diabetic activity of these novel phytocompounds warrants further functional studies.
    In vivo:
    Diabetes. 2013 Feb;62(2):628-38.
    Antidiabetic effects of pterosin A, a small-molecular-weight natural product, on diabetic mouse models.[Pubmed: 23069626 ]
    The therapeutic effect of Pterosin A, a small-molecular-weight natural product, on diabetes was investigated. Pterosin A, administered orally for 4 weeks, effectively improved hyperglycemia and glucose intolerance in streptozotocin, high-fat diet-fed, and db/db diabetic mice.
    METHODS AND RESULTS:
    There were no adverse effects in normal or diabetic mice treated with Pterosin A for 4 weeks. Pterosin A significantly reversed the increased serum insulin and insulin resistance (IR) in dexamethasone-IR mice and in db/db mice. Pterosin A significantly reversed the reduced muscle GLUT-4 translocation and the increased liver phosphoenolpyruvate carboxyl kinase (PEPCK) expression in diabetic mice. Pterosin A also significantly reversed the decreased phosphorylations of AMP-activated protein kinase (AMPK) and Akt in muscles of diabetic mice. The decreased AMPK phosphorylation and increased p38 phosphorylation in livers of db/db mice were effectively reversed by Pterosin A. Pterosin A enhanced glucose uptake and AMPK phosphorylation in cultured human muscle cells. In cultured liver cells, Pterosin A inhibited inducer-enhanced PEPCK expression, triggered the phosphorylations of AMPK, acetyl CoA carboxylase, and glycogen synthase kinase-3, decreased glycogen synthase phosphorylation, and increased the intracellular glycogen level.
    CONCLUSIONS:
    These findings indicate that Pterosin A may be a potential therapeutic option for diabetes.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.03 mL 20.1499 mL 40.2998 mL 80.5997 mL 100.7496 mL
    5 mM 0.806 mL 4.03 mL 8.06 mL 16.1199 mL 20.1499 mL
    10 mM 0.403 mL 2.015 mL 4.03 mL 8.06 mL 10.075 mL
    50 mM 0.0806 mL 0.403 mL 0.806 mL 1.612 mL 2.015 mL
    100 mM 0.0403 mL 0.2015 mL 0.403 mL 0.806 mL 1.0075 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    蕨素D; Pterosin D CFN98443 34169-70-5 C15H20O3 = 248.3 5mg QQ客服:3257982914
    Pterolactone A; Pterolactone A CFN96247 74730-10-2 C15H16O4 = 260.3 5mg QQ客服:2056216494
    蕨苷D; Pteroside D CFN98485 35943-38-5 C21H30O8 = 410.5 5mg QQ客服:1413575084
    表蕨素D 3-O-葡萄糖苷; Pterosin D 3-O-glucoside CFN97608 84299-80-9 C21H30O8 = 410.46 5mg QQ客服:2056216494
    表蕨素L; Epipterosin L CFN98865 52611-75-3 C15H20O4 = 264.3 5mg QQ客服:1413575084
    表蕨素L 2'-O-葡萄糖苷; Epipterosin L 2'-O-glucoside CFN97719 61117-89-3 C21H30O9 = 426.46 5mg QQ客服:1457312923
    (2R)-去甲蕨素 B; Norpterosin B CFN96799 1226892-20-1 C13H16O2 = 204.26 5mg QQ客服:1457312923
    去甲蕨素 B 葡萄糖苷; Norpterosin B glucoside CFN89000 1226785-88-1 C19H26O7 = 366.41 5mg QQ客服:2159513211
    蕨素 B ; Pterosin B CFN96798 34175-96-7 C14H18O2 = 218.29 5mg QQ客服:3257982914
    反式-去甲蕨素 C ; trans-Norpterosin C CFN96609 64890-70-6 C13H16O3 = 220.27 5mg QQ客服:2056216494

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