(R)-伪可卡因
Pseudococaine
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| (R)-伪可卡因 |
CFN00184 |
478-73-9 |
1mg |
QQ客服：215959384 |
| (R)-伪可卡因 |
CFN00184 |
478-73-9 |
5mg |
QQ客服：215959384 |
| (R)-伪可卡因 |
CFN00184 |
478-73-9 |
10mg |
QQ客服：215959384 |
| (R)-伪可卡因 |
CFN00184 |
478-73-9 |
20mg |
QQ客服：215959384 |
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国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
Pseudococaine produces high-voltage slow waves (HVSWs) in the EEG associated with behavioral depression, it is more potent than cocaine in producing convulsions in the same monkeys. |
| In vivo: |
| Brain Res Bull. 1978 Jul-Aug;3(4):341-7. | | Cocaine and pseudococaine: comparative effects on electrical after-discharge in the limbic system of cats.[Pubmed: 318203 ] |
METHODS AND RESULTS:
The effects of cocaine and its dextroisomer pseudococaine on electrical after-discharge (AD) evoked by electrical stimulation of the hippocampus or amygdala were studied in cats with electrodes implanted in the brain. Intravenous injection of cocaine (2.0 to 4.0 mg/kg doses) produced a suppressive effect on the AD while producing low-voltage fast waves (LVFWs) in the electrical activities of the brain (EEG) associated with behavioral excitation. In contrast, pseudococaine at the same dose as cocaine failed to show a significant suppressive effect on the AD except at high doses (5.0 mg/kg). Pseudococaine produced high-voltage slow waves (HVSWs) in the EEG associated with behavioral depression. A linear dose-response relationship was observed for the suppressive effect of cocaine on the AD.
CONCLUSIONS:
The results suggested that the limbic system may be involved as a primary site of action of cocaine in the central nervous system (CNS). | | Brain Res Bull. 1977 Nov-Dec;2(6):417-24. | | Comparison of the convulsant effects of cocaine and pseudococaine in the rhesus monkey.[Pubmed: 414826] |
METHODS AND RESULTS:
The convulsant effects of cocaine and its C2-epimer, Pseudococaine on EEG, respiration, heart rate and behavior were studied in the rhesus monkeys with electrodes implanted in the brain. Intravenous injections of cocaine (3.0 to 8.0 mg/kg) and Pseudococaine (3.0 to 7.0 mg/kg) in the animals produced a similar pattern of clonic convulsions accompanied by marked increases in the heart and respiratory rates with mydriasis and excessive salivation. However, both isomers showed different effects on the EEG and animal's behavior following convulsions; e.g., the cocaine-induced convulsions were followed by low-voltage fast waves in the EEGs associated with behavioral hyperexcitation, while Pseudococaine-induced convulsions were followed by high-voltage slow waves associated with behavioral depression and drowsiness with intermittent sleep.
CONCLUSIONS:
Pseudococaine was more potent than cocaine in producing convulsions in the same monkeys. The durations of convulsions produced by these drugs were dose-dependent. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
3.2965 mL |
16.4826 mL |
32.9652 mL |
65.9304 mL |
82.4131 mL |
| 5 mM |
0.6593 mL |
3.2965 mL |
6.593 mL |
13.1861 mL |
16.4826 mL |
| 10 mM |
0.3297 mL |
1.6483 mL |
3.2965 mL |
6.593 mL |
8.2413 mL |
| 50 mM |
0.0659 mL |
0.3297 mL |
0.6593 mL |
1.3186 mL |
1.6483 mL |
| 100 mM |
0.033 mL |
0.1648 mL |
0.3297 mL |
0.6593 mL |
0.8241 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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