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  • (R)-伪可卡因

    • (R)-伪可卡因

    Pseudococaine

    (R)-伪可卡因
    		产品编号 CFN00184
    CAS编号 478-73-9
    分子式 = 分子量 C17H21NO4 = 303.35
    产品纯度 >=98%
    物理属性 Cryst.
    化合物类型 Alkaloids
    植物来源 The leaves of the coca plant .
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    (R)-伪可卡因 CFN00184 478-73-9 1mg QQ客服：2056216494
    (R)-伪可卡因 CFN00184 478-73-9 5mg QQ客服：2056216494
    (R)-伪可卡因 CFN00184 478-73-9 10mg QQ客服：2056216494
    (R)-伪可卡因 CFN00184 478-73-9 20mg QQ客服：2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Planta Medica International2022, 9(01):e108-e115.
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  • Molecules.2021, 26(16):4722.
  • Cell Physiol Biochem.2017, 44(4):1381-1395
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  • ...
    • 生物活性
    Description: Pseudococaine produces high-voltage slow waves (HVSWs) in the EEG associated with behavioral depression, it is more potent than cocaine in producing convulsions in the same monkeys.
    In vivo:
    Brain Res Bull. 1978 Jul-Aug;3(4):341-7.
    Cocaine and pseudococaine: comparative effects on electrical after-discharge in the limbic system of cats.[Pubmed: 318203 ]

    METHODS AND RESULTS:
    The effects of cocaine and its dextroisomer pseudococaine on electrical after-discharge (AD) evoked by electrical stimulation of the hippocampus or amygdala were studied in cats with electrodes implanted in the brain. Intravenous injection of cocaine (2.0 to 4.0 mg/kg doses) produced a suppressive effect on the AD while producing low-voltage fast waves (LVFWs) in the electrical activities of the brain (EEG) associated with behavioral excitation. In contrast, pseudococaine at the same dose as cocaine failed to show a significant suppressive effect on the AD except at high doses (5.0 mg/kg). Pseudococaine produced high-voltage slow waves (HVSWs) in the EEG associated with behavioral depression. A linear dose-response relationship was observed for the suppressive effect of cocaine on the AD.
    CONCLUSIONS:
    The results suggested that the limbic system may be involved as a primary site of action of cocaine in the central nervous system (CNS).
    Brain Res Bull. 1977 Nov-Dec;2(6):417-24.
    Comparison of the convulsant effects of cocaine and pseudococaine in the rhesus monkey.[Pubmed: 414826]

    METHODS AND RESULTS:
    The convulsant effects of cocaine and its C2-epimer, Pseudococaine on EEG, respiration, heart rate and behavior were studied in the rhesus monkeys with electrodes implanted in the brain. Intravenous injections of cocaine (3.0 to 8.0 mg/kg) and Pseudococaine (3.0 to 7.0 mg/kg) in the animals produced a similar pattern of clonic convulsions accompanied by marked increases in the heart and respiratory rates with mydriasis and excessive salivation. However, both isomers showed different effects on the EEG and animal's behavior following convulsions; e.g., the cocaine-induced convulsions were followed by low-voltage fast waves in the EEGs associated with behavioral hyperexcitation, while Pseudococaine-induced convulsions were followed by high-voltage slow waves associated with behavioral depression and drowsiness with intermittent sleep.
    CONCLUSIONS:
    Pseudococaine was more potent than cocaine in producing convulsions in the same monkeys. The durations of convulsions produced by these drugs were dose-dependent.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.2965 mL 16.4826 mL 32.9652 mL 65.9304 mL 82.4131 mL
    5 mM 0.6593 mL 3.2965 mL 6.593 mL 13.1861 mL 16.4826 mL
    10 mM 0.3297 mL 1.6483 mL 3.2965 mL 6.593 mL 8.2413 mL
    50 mM 0.0659 mL 0.3297 mL 0.6593 mL 1.3186 mL 1.6483 mL
    100 mM 0.033 mL 0.1648 mL 0.3297 mL 0.6593 mL 0.8241 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    樟柳碱; Anisodine CFN00148 52646-92-1 C17H21NO5 = 319.36 5mg QQ客服：215959384
    阿朴阿托品; Apoatropine CFN00149 500-55-0 C17H21NO2 = 271.36 5mg QQ客服：215959384
    东茛菪碱; Apohyoscine CFN00150 535-26-2 C17H19NO3 = 285.34 5mg QQ客服：1457312923
    Aponorhyoscine; Aponorhyoscine CFN00151 25650-56-0 C16H17NO3 = 271.31 5mg QQ客服：3257982914
    Nortropacocaine; Nortropacocaine CFN00171 18470-33-2 C14H17NO2 = 231.29 5mg QQ客服：3257982914
    Bellendine; Bellendine CFN00177 32152-73-1 C12H15NO2 = 205.26 5mg QQ客服：1413575084
    Brugine; Brugine CFN00181 14912-30-2 C12H19NO2S2 = 273.42 5mg QQ客服：2159513211
    Chalcostrobamine; Chalcostrobamine CFN00182 75638-72-1 C17H19NO2 = 269.34 5mg QQ客服：3257982914
    可卡因; Cocaine CFN00183 50-36-2 C17H21NO4 = 303.35 5mg QQ客服：1457312923
    (R)-伪可卡因; Pseudococaine CFN00184 478-73-9 C17H21NO4 = 303.35 5mg QQ客服：2056216494

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