(R)-伪可卡因

Pseudococaine

	产品编号	CFN00184
	CAS编号	478-73-9
	分子式 = 分子量	C₁₇H₂₁NO₄ = 303.35
	产品纯度	>=98%
	物理属性	Cryst.
	化合物类型	Alkaloids
	植物来源	The leaves of the coca plant .
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
(R)-伪可卡因	CFN00184	478-73-9	1mg	QQ客服：1457312923
(R)-伪可卡因	CFN00184	478-73-9	5mg	QQ客服：1457312923
(R)-伪可卡因	CFN00184	478-73-9	10mg	QQ客服：1457312923
(R)-伪可卡因	CFN00184	478-73-9	20mg	QQ客服：1457312923

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Description:

Pseudococaine produces high-voltage slow waves (HVSWs) in the EEG associated with behavioral depression, it is more potent than cocaine in producing convulsions in the same monkeys.

In vivo:

Brain Res Bull. 1978 Jul-Aug;3(4):341-7.

Cocaine and pseudococaine: comparative effects on electrical after-discharge in the limbic system of cats.[Pubmed: 318203 ]

METHODS AND RESULTS:
The effects of cocaine and its dextroisomer pseudococaine on electrical after-discharge (AD) evoked by electrical stimulation of the hippocampus or amygdala were studied in cats with electrodes implanted in the brain. Intravenous injection of cocaine (2.0 to 4.0 mg/kg doses) produced a suppressive effect on the AD while producing low-voltage fast waves (LVFWs) in the electrical activities of the brain (EEG) associated with behavioral excitation. In contrast, pseudococaine at the same dose as cocaine failed to show a significant suppressive effect on the AD except at high doses (5.0 mg/kg). Pseudococaine produced high-voltage slow waves (HVSWs) in the EEG associated with behavioral depression. A linear dose-response relationship was observed for the suppressive effect of cocaine on the AD.
CONCLUSIONS:
The results suggested that the limbic system may be involved as a primary site of action of cocaine in the central nervous system (CNS).

Brain Res Bull. 1977 Nov-Dec;2(6):417-24.

Comparison of the convulsant effects of cocaine and pseudococaine in the rhesus monkey.[Pubmed: 414826]

METHODS AND RESULTS:
The convulsant effects of cocaine and its C2-epimer, Pseudococaine on EEG, respiration, heart rate and behavior were studied in the rhesus monkeys with electrodes implanted in the brain. Intravenous injections of cocaine (3.0 to 8.0 mg/kg) and Pseudococaine (3.0 to 7.0 mg/kg) in the animals produced a similar pattern of clonic convulsions accompanied by marked increases in the heart and respiratory rates with mydriasis and excessive salivation. However, both isomers showed different effects on the EEG and animal's behavior following convulsions; e.g., the cocaine-induced convulsions were followed by low-voltage fast waves in the EEGs associated with behavioral hyperexcitation, while Pseudococaine-induced convulsions were followed by high-voltage slow waves associated with behavioral depression and drowsiness with intermittent sleep.
CONCLUSIONS:
Pseudococaine was more potent than cocaine in producing convulsions in the same monkeys. The durations of convulsions produced by these drugs were dose-dependent.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
樟柳碱; Anisodine	CFN00148	52646-92-1	C₁₇H₂₁NO₅ = 319.36	5mg	QQ客服：2159513211
阿朴阿托品; Apoatropine	CFN00149	500-55-0	C₁₇H₂₁NO₂ = 271.36	5mg	QQ客服：2056216494
东茛菪碱; Apohyoscine	CFN00150	535-26-2	C₁₇H₁₉NO₃ = 285.34	5mg	QQ客服：1457312923
Aponorhyoscine; Aponorhyoscine	CFN00151	25650-56-0	C₁₆H₁₇NO₃ = 271.31	5mg	QQ客服：3257982914
Nortropacocaine; Nortropacocaine	CFN00171	18470-33-2	C₁₄H₁₇NO₂ = 231.29	5mg	QQ客服：2056216494
Bellendine; Bellendine	CFN00177	32152-73-1	C₁₂H₁₅NO₂ = 205.26	5mg	QQ客服：2159513211
Brugine; Brugine	CFN00181	14912-30-2	C₁₂H₁₉NO₂S₂ = 273.42	5mg	QQ客服：1413575084
Chalcostrobamine; Chalcostrobamine	CFN00182	75638-72-1	C₁₇H₁₉NO₂ = 269.34	5mg	QQ客服：1413575084
可卡因; Cocaine	CFN00183	50-36-2	C₁₇H₂₁NO₄ = 303.35	5mg	QQ客服：1413575084
(R)-伪可卡因; Pseudococaine	CFN00184	478-73-9	C₁₇H₂₁NO₄ = 303.35	5mg	QQ客服：1413575084

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.2965 mL	16.4826 mL	32.9652 mL	65.9304 mL	82.4131 mL
5 mM	0.6593 mL	3.2965 mL	6.593 mL	13.1861 mL	16.4826 mL
10 mM	0.3297 mL	1.6483 mL	3.2965 mL	6.593 mL	8.2413 mL
50 mM	0.0659 mL	0.3297 mL	0.6593 mL	1.3186 mL	1.6483 mL
100 mM	0.033 mL	0.1648 mL	0.3297 mL	0.6593 mL	0.8241 mL