可卡因

Cocaine

	产品编号	CFN00183
	CAS编号	50-36-2
	分子式 = 分子量	C₁₇H₂₁NO₄ = 303.35
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源	The leaves of the coca plant.
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产品名称	产品编号	CAS编号	包装	QQ客服
可卡因	CFN00183	50-36-2	1mg	QQ客服：3257982914
可卡因	CFN00183	50-36-2	5mg	QQ客服：3257982914
可卡因	CFN00183	50-36-2	10mg	QQ客服：3257982914
可卡因	CFN00183	50-36-2	20mg	QQ客服：3257982914

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Description:

Cocaine is a powerfully addictive stimulant drug made from the leaves of the coca plant native to South America, it produces short-term euphoria. Cocaine has a small number of accepted medical uses such as numbing and decreasing bleeding during nasal surgery, it constricts blood vessels, dilates pupils, and increases body temperature, heart rate, and blood pressure. Cocaine sensitizes VTA cells to the excitatory effects of both CRF and orexin-A, thus providing a mechanism by which stress induces Cocaine seeking.Cocaine also can cause headaches and gastrointestinal complications such as abdominal pain and nausea. Because cocaine tends to decrease appetite, chronic users can become malnourished as well.

Targets:

NMDAR | HIV | gp120/CD4

In vivo:

Psychiatry Res. 2015 Feb 28;225(3):309-14.

Changes in brain-derived neurotrophic factor (BDNF) during abstinence could be associated with relapse in cocaine-dependent patients.[Pubmed: 25592977 ]

Brain-derived neurotrophic factor (BDNF) is involved in cocaine craving in humans and drug seeking in rodents. Based on this, the aim of this study was to explore the possible role of serum BDNF in cocaine relapse in abstinent addicts.
METHODS AND RESULTS:
Forty cocaine dependent subjects (DSM-IV criteria) were included in an inpatient 2 weeks abstinence program. Organic and psychiatric co-morbidities were excluded. Two serum samples were collected for each subject at baseline and at after 14 abstinence days. After discharge, all cocaine addicts underwent a 22 weeks follow-up, after which they were classified into early relapsers (ER) (resumed during the first 14 days after discharge,) or late relapsers (LR) (resumed beyond 14 days after discharge). The only clinical differences between groups were the number of consumption days during the last month before detoxification. Serum BDNF levels increased significantly across the 12 days of abstinence in the LR group (p=0.02), whereas in the ER group BDNF remained unchanged. In the ER group, the change of serum BDNF during abstinence negatively correlated with the improvement in depressive symptoms (p=0.02).
CONCLUSIONS:
These results suggest that BDNF has a role in relapse to cocaine consumption in abstinent addicts, although the underlying neurobiological mechanisms remain to be clarified.

South Med J. 2015 Feb;108(2):130-1.

Effects of cocaine-positive urine screens on serum thyrotropin levels in patients admitted to an inpatient mental health unit.[Pubmed: 25688900]

To assess the effect of a positive urine screen for Cocaine on thyrotropin (TSH, also thyroid-stimulating hormone) concentrations.
METHODS AND RESULTS:
In this retrospective cohort study, patients admitted to the mental health unit at an academic inpatient setting with a diagnosis of Cocaine dependence or Cocaine intoxication were routinely screened with urine drug toxicology tests and TSH concentrations. TSH concentrations from patients who tested positive for Cocaine on urine toxicology were compared with patients having negative Cocaine screenings. A total of 192 patients were included: 122 with a positive Cocaine screen and 70 with a negative Cocaine screen. All patients were screened using a highly sensitive TSH assay. A positive Cocaine screen was not associated with a statistically significant difference in TSH concentrations compared with a negative Cocaine screen. The percentage of patients with hypothyroidism (TSH >4.50 μIU/mL) or hyperthyroidism (TSH <0.40 μIU/mL) were similar in both study groups.
CONCLUSIONS:
The study failed to show that a positive urine screen for Cocaine was associated with a significant effect on serum TSH levels in patients admitted to a mental health unit with a diagnosis of Cocaine dependence or Cocaine intoxication. Our findings support those of a prior study that Cocaine use does not affect routine thyroid function tests. The present study does not support the clinical practice of ordering a serum TSH screening test on patients admitted to inpatient psychiatry units soley because the urine screen is positive for Cocaine.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
樟柳碱; Anisodine	CFN00148	52646-92-1	C₁₇H₂₁NO₅ = 319.36	5mg	QQ客服：2056216494
阿朴阿托品; Apoatropine	CFN00149	500-55-0	C₁₇H₂₁NO₂ = 271.36	5mg	QQ客服：215959384
东茛菪碱; Apohyoscine	CFN00150	535-26-2	C₁₇H₁₉NO₃ = 285.34	5mg	QQ客服：1413575084
Aponorhyoscine; Aponorhyoscine	CFN00151	25650-56-0	C₁₆H₁₇NO₃ = 271.31	5mg	QQ客服：2159513211
Nortropacocaine; Nortropacocaine	CFN00171	18470-33-2	C₁₄H₁₇NO₂ = 231.29	5mg	QQ客服：1413575084
Bellendine; Bellendine	CFN00177	32152-73-1	C₁₂H₁₅NO₂ = 205.26	5mg	QQ客服：3257982914
Brugine; Brugine	CFN00181	14912-30-2	C₁₂H₁₉NO₂S₂ = 273.42	5mg	QQ客服：3257982914
Chalcostrobamine; Chalcostrobamine	CFN00182	75638-72-1	C₁₇H₁₉NO₂ = 269.34	5mg	QQ客服：1413575084
可卡因; Cocaine	CFN00183	50-36-2	C₁₇H₂₁NO₄ = 303.35	5mg	QQ客服：1457312923
(R)-伪可卡因; Pseudococaine	CFN00184	478-73-9	C₁₇H₂₁NO₄ = 303.35	5mg	QQ客服：1413575084

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.2965 mL	16.4826 mL	32.9652 mL	65.9304 mL	82.4131 mL
5 mM	0.6593 mL	3.2965 mL	6.593 mL	13.1861 mL	16.4826 mL
10 mM	0.3297 mL	1.6483 mL	3.2965 mL	6.593 mL	8.2413 mL
50 mM	0.0659 mL	0.3297 mL	0.6593 mL	1.3186 mL	1.6483 mL
100 mM	0.033 mL	0.1648 mL	0.3297 mL	0.6593 mL	0.8241 mL

可卡因

Cocaine

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