| Psychiatry Res. 2015 Feb 28;225(3):309-14. |
| Changes in brain-derived neurotrophic factor (BDNF) during abstinence could be associated with relapse in cocaine-dependent patients.[Pubmed: 25592977 ] |
Brain-derived neurotrophic factor (BDNF) is involved in cocaine craving in humans and drug seeking in rodents. Based on this, the aim of this study was to explore the possible role of serum BDNF in cocaine relapse in abstinent addicts.
METHODS AND RESULTS:
Forty cocaine dependent subjects (DSM-IV criteria) were included in an inpatient 2 weeks abstinence program. Organic and psychiatric co-morbidities were excluded. Two serum samples were collected for each subject at baseline and at after 14 abstinence days. After discharge, all cocaine addicts underwent a 22 weeks follow-up, after which they were classified into early relapsers (ER) (resumed during the first 14 days after discharge,) or late relapsers (LR) (resumed beyond 14 days after discharge). The only clinical differences between groups were the number of consumption days during the last month before detoxification. Serum BDNF levels increased significantly across the 12 days of abstinence in the LR group (p=0.02), whereas in the ER group BDNF remained unchanged. In the ER group, the change of serum BDNF during abstinence negatively correlated with the improvement in depressive symptoms (p=0.02).
CONCLUSIONS:
These results suggest that BDNF has a role in relapse to cocaine consumption in abstinent addicts, although the underlying neurobiological mechanisms remain to be clarified. |
| South Med J. 2015 Feb;108(2):130-1. |
| Effects of cocaine-positive urine screens on serum thyrotropin levels in patients admitted to an inpatient mental health unit.[Pubmed: 25688900] |
To assess the effect of a positive urine screen for Cocaine on thyrotropin (TSH, also thyroid-stimulating hormone) concentrations.
METHODS AND RESULTS:
In this retrospective cohort study, patients admitted to the mental health unit at an academic inpatient setting with a diagnosis of Cocaine dependence or Cocaine intoxication were routinely screened with urine drug toxicology tests and TSH concentrations. TSH concentrations from patients who tested positive for Cocaine on urine toxicology were compared with patients having negative Cocaine screenings. A total of 192 patients were included: 122 with a positive Cocaine screen and 70 with a negative Cocaine screen. All patients were screened using a highly sensitive TSH assay. A positive Cocaine screen was not associated with a statistically significant difference in TSH concentrations compared with a negative Cocaine screen. The percentage of patients with hypothyroidism (TSH >4.50 μIU/mL) or hyperthyroidism (TSH <0.40 μIU/mL) were similar in both study groups.
CONCLUSIONS:
The study failed to show that a positive urine screen for Cocaine was associated with a significant effect on serum TSH levels in patients admitted to a mental health unit with a diagnosis of Cocaine dependence or Cocaine intoxication. Our findings support those of a prior study that Cocaine use does not affect routine thyroid function tests.
The present study does not support the clinical practice of ordering a serum TSH screening test on patients admitted to inpatient psychiatry units soley because the urine screen is positive for Cocaine. |
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