原纤细薯蓣皂苷

Protogracillin

	产品编号	CFN93054
	CAS编号	54848-30-5
	分子式 = 分子量	C₅₁H₈₄O₂₃ = 1065.21
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Steroids
	植物来源	The roots of Dioscorea opposita Thunb.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
原纤细薯蓣皂苷	CFN93054	54848-30-5	1mg	QQ客服：215959384
原纤细薯蓣皂苷	CFN93054	54848-30-5	5mg	QQ客服：215959384
原纤细薯蓣皂苷	CFN93054	54848-30-5	10mg	QQ客服：215959384
原纤细薯蓣皂苷	CFN93054	54848-30-5	20mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Wuerzburg (Germany)

Ateneo de Manila University (Philippines)

The University of Newcastle (Australia)

Agricultural Research Organization (ARO) (Israel)

University of Toronto (Canada)

Korea Institute of Oriental Medicine (Korea)

Griffith University (Australia)

Macau University of Science and Technology (China)

Seoul National University of Science and Technology (Korea)

Universidade Católica Portuguesa (Portugal)

Center for protein Engineering (CIP) (Belgium)

Cancer Research Initatives Foundation(CARIF) (Malaysia)

University of Sao Paulo (Brazil)

Universite de Lille1 (France)

More...

Description:

Protogracillin may have inhibitions on platelet aggregation (PAG) and thrombosis.

In vitro:

Anticancer Agents Med Chem. 2014;14(6):833-9.

Paris polyphylla: chemical and biological prospectives.[Pubmed: 24917072]

Paris polyphylla J.E. Smith is extensively used in traditional systems of Indian and Chinese medicines mainly for its anticancerous property. The national and international demand for P. polyphylla is constantly increasing and most of the supplies come from wild. Illegal and unscientific exploitation coupled with habitat destruction decreases the natural population of the herb, as a consequence this species comes under vulnerable category. Restoration and conservation of the natural population of this potential herb is prerequisites.
METHODS AND RESULTS:
This article aims to provide an overview on chemical and biological prospective of P. polyphylla. Secondary metabolites such as daucosterol, polyphyllin D, β -ecdysterone, Paris saponins I, II, V, VI, VII, H, dioscin, oligosaccharides, heptasaccharide, octasaccharide, trigofoenoside A, Protogracillin, Paris yunnanosides G-J, padelaoside B, pinnatasterone, formosanin C and 20-hydroxyecdyson saponins have been isolated from P. polyphylla. Several biological activities such as anticancerous, antitumor, cytotoxic, anthelmintic, antimicrobial, antiangiogenic, immunostimulating, contractile and hemostatic have also been reported.
CONCLUSIONS:
Consequently, this review will be helpful to the researcher and scientist for further research.

In vivo:

Fitoterapia. 2010 Dec;81(8):1147-56.

Anti-thrombotic activity and chemical characterization of steroidal saponins from Dioscorea zingiberensis C.H. Wright.[Pubmed: 20659537 ]

Steroidal saponins have long attracted scientific attention, due to their structural diversity and significant biological activities. Total steroidal saponins (TSS) extracted from the rhizomes of Dioscorea zingiberensis C.H. Wright (DZW) constitute an effective treatment for cardiovascular disease. However, the active constituents contained in DZW rhizomes and their pharmacological properties are not fully understood. The aim of this work is to determine and quantify the active constituents in DZW rhizomes using fingerprint technique, and evaluate its anti-thrombotic activity using inferior vena cava ligation thrombosis rat model and pulmonary thrombosis mice model after being gavaged with TSS for 1 or 2weeks.
METHODS AND RESULTS:
In the study, a chemical fingerprint method was firstly established and validated to quantify and standardize TSS from DZW rhizomes including parvifloside, protodeltonin, protodioscin, Protogracillin, zingiberensis saponin, deltonin, dioscin and trillin. TSS extracted from DZW rhizomes were showed to have the inhibitions on platelet aggregation (PAG) and thrombosis, and prolong activated partial thromboplastin time (APTT), thrombin time (TT), and prothrombin time (PT) in a dose-dependent manner in rats. TSS also prolonged the bleeding time and clotting time in a dose-dependent manner in mice.
CONCLUSIONS:
The results indicate that TSS could inhibit thrombosis by both improving the anticoagulation activity and inhibiting PAG action, suggesting that TSS from DZW rhizomes have the potential to reduce the risk of cardiovascular diseases by anti-thrombotic action.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
原皂苷Pa; Parisaponin I	CFN90702	561007-63-4	C₅₀H₈₂O₂₂ = 1034.0	5mg	QQ客服：2159513211
原皂苷Pb; Dichotomin	CFN90703	53093-47-3	C₅₇H₉₄O₂₆ = 1195.34	5mg	QQ客服：2159513211
知母皂苷B; Anemarsaponin B	CFN99532	139051-27-7	C₄₅H₇₄O₁₈ = 903.04	20mg	QQ客服：3257982914
知母皂苷BIII; Anemarsaponin BIII	CFN90778	142759-74-8	C₄₅H₇₄O₁₈ = 903.1	5mg	QQ客服：3257982914
知母皂苷C; Timorsaponin C	CFN90779	185432-00-2	C₄₅H₇₄O₁₈ = 903.1	5mg	QQ客服：2056216494
伪原皂苷Pa; Parisyunnanoside B	CFN90704	945865-37-2	C₅₀H₈₀O₂₁ = 1016.0	10mg	QQ客服：2159513211
伪原薯蓣皂苷; Pseudoprotodioscin	CFN90694	102115-79-7	C₅₁H₈₂O₂ = 1031.18	20mg	QQ客服：3257982914
黄山药皂苷C; Dioscoreside C	CFN95345	344912-80-7	C₅₂H₈₄O₂₂ = 1061.2	5mg	QQ客服：3257982914
黄山药皂苷E; Dioscoreside E	CFN95346	435321-73-6	C₅₂H₈₄O₂₃ = 1077.2	5mg	QQ客服：1457312923
蒺藜皂苷K; Terrestrosin K	CFN90822	193605-07-1	C₅₁H₈₂O₂₄ = 1079.2	10mg	QQ客服：215959384

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	0.9388 mL	4.6939 mL	9.3878 mL	18.7756 mL	23.4696 mL
5 mM	0.1878 mL	0.9388 mL	1.8776 mL	3.7551 mL	4.6939 mL
10 mM	0.0939 mL	0.4694 mL	0.9388 mL	1.8776 mL	2.347 mL
50 mM	0.0188 mL	0.0939 mL	0.1878 mL	0.3755 mL	0.4694 mL
100 mM	0.0094 mL	0.0469 mL	0.0939 mL	0.1878 mL	0.2347 mL

原纤细薯蓣皂苷

Protogracillin

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