重楼皂苷G

Polyphyllin G

	产品编号	CFN99955
	CAS编号	76296-75-8
	分子式 = 分子量	C₅₁H₈₄O₂₂ = 1049.22
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Steroids
	植物来源	The rhizomes of Paris yunnanensis Franch.
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产品名称	产品编号	CAS编号	包装	QQ客服
重楼皂苷G	CFN99955	76296-75-8	1mg	QQ客服：2159513211
重楼皂苷G	CFN99955	76296-75-8	5mg	QQ客服：2159513211
重楼皂苷G	CFN99955	76296-75-8	10mg	QQ客服：2159513211
重楼皂苷G	CFN99955	76296-75-8	20mg	QQ客服：2159513211

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Description:

Polyphyllin G has been shown to have strong anticancer activities in a wide variety of human cancer cell lines, it also shows signiﬁcant anthelmintic activity against Dactylogyrus intermedius with EC50 values of 1.2 mg L(-1) and the acute toxicities (LC50) values of 2.9 mg L(-1).

Targets:

In vitro:

Phytomedicine. 2016 Dec 1;23(13):1545-1554.

Polyphyllin G induces apoptosis and autophagy cell death in human oral cancer cells.[Pubmed: 27823618]

Polyphyllin G (also called polyphyllin VII), extract from rhizomes of Paris yunnanensis Franch, has been shown to have strong anticancer activities in a wide variety of human cancer cell lines. However, the underlying influences of autophagy in human oral squamous cell carcinoma (OSCC) remain unclear.
METHODS AND RESULTS:
In this study, the roles of apoptosis and autophagy in polyphyllin G-induced death in human oral cancer cells were investigated. Moreover, the molecular mechanism of the anticancer effects of polyphyllin G in human oral cancer cells was investigated. The results revealed that polyphyllin G significantly inhibited cell proliferation in human oral cancer cells; it dose-dependently induced apoptosis in SAS and OECM-1 cells through caspase-3, -8, and -9 activation and poly (ADP-ribose) polymerase cleavage. In addition, changes were observed in Bcl-2 and proapoptosis-related protein expression in different human oral cancer cell lines. The expression of both LC3-II and beclin-1 was markedly increased, suggesting the induction of autophagy in polyphyllin G-treated oral cells. To further clarify whether polyphyllin G-induced apoptosis and autophagy depended on Akt/extracellular signal-regulated kinases (ERK)/c-Jun N-terminal kinases (JNK)/p38 mitogen-activated protein kinases (MAPK) signaling pathways, the cells were cotreated with inhibitors. The results demonstrated polyphyllin G-induced apoptosis in oral cells through the activation of ERK, Akt, p38 MAPK, and JNK, whereas ERK and JNK accounted for polyphyllin G-induced autophagy.
CONCLUSIONS:
This study is the first to demonstrate apoptosis and autophagy during polyphyllin G-induced cell death in human oral cancer cell lines. These results suggest that polyphyllin G is a promising candidate for developing antitumor drugs targeting human oral squamous cell carcinoma.

Arch Biochem Biophys . 2018 Apr 15;644:93-99.

Polyphyllin G exhibits antimicrobial activity and exerts anticancer effects on human oral cancer OECM-1 cells by triggering G2/M cell cycle arrest by inactivating cdc25C-cdc2[Pubmed: 29352966]

Abstract Plant natural products have long been considered to be important sources of bioactive molecules. A large number of antimicrobial and anticancer agents have been isolated form plants. In the present study we evaluated the antimicrobial and anticancer activity of a plant derived secondery metabolite, Polyphyllin G. The results of antibacterial assays showed that Polyphyllin G prevented the growth of both Gram-positive and Gram-negative bacteria with minimum inhibitory concentrations (MICs) ranging from 13.1 to 78 μg/ml. Antifungal activity measured as inhibition of mycelium growth ranged between 38.32 and 56.50%. Further Polyphyllin G was also evaluated against a panel of cancer cell lines. The IC50 of Polyphyllin G ranged from 10 to 65 μM. However the IC50 of Polyphyllin G was found to be comparatively high (120 μM) against the normal FR2 cancer cell line. The lowest IC50 of 10 μM was found against the oral cancer cell line OECM-1. Therefore further studies were carried out on this cell line only. Our results indicated that Polyphyllin G induced cell arrest in oral cancer OECM-1 cells by inactivation of cdc25C-cdc22 via ATM-Chk 1/2 stimulation. Therefore, we propose that Polyphyllin G might prove a lead molecule in the management of oral cancers and at the same time may prevent the growth of opportunistic microbes. Keywords: Anticancer; Antimicrobial; Cell cycle arrest; Metastasis; Oral cancer; Polyphyllin G.

In vivo:

Parasitology. 2013 Jul;140(8):952-8.

Identification of compounds from Paris polyphylla (ChongLou) active against Dactylogyrus intermedius.[Pubmed: 23552446]

The present study was designated to ascertain the anthelmintic activity of the rhizomes of Paris polyphylla and to isolate and characterize the active constituents.
METHODS AND RESULTS:
The methanol extract from rhizomes of P. polyphylla showed signiﬁcant anthelmintic activity against Dactylogyrus intermedius with the median effective concentration (EC50) 22.5 mg L(-1). Based on this finding, the methanol extract was fractionated by silica gel column chromatography in a bioassay-guided fractionation yielding 2 bioactive compounds, the structures of these compounds were elucidated as formosanin C and polyphyllin VII(Polyphyllin G). The in vivo tests revealed that formosanin C and polyphyllin VII were significantly effective against D. intermedius with EC50 values of 0.6 and 1.2 mg L(-1), respectively. The acute toxicities (LC50) of formosanin C and polyphyllin VII for grass carp were 2.8 and 2.9 mg L(-1), respectively.
CONCLUSIONS:
The overall results provide important information for the potential application of formosanin C and polyphyllin VII in the therapy of serious infection caused by D. intermedius.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
知母皂苷E; Anemarsaponin E	CFN99533	136565-73-6	C₄₆H₇₈O₁₉ = 934.03	10mg	QQ客服：3257982914
(3beta,22alpha)-26-(beta-glucopyranosyloxy)-22-methoxyfurost-5-en-3-yl 2-O-(6-deoxy-alpha-mannopyranosyl)-beta-glucopyranosiduronic acid; (3beta,22alpha)-26-(beta-glucopyranosyloxy)-22-methoxyfurost-5-en-3-yl 2-O-(6-deoxy-alpha-mannopyranosyl)-beta-glucopyranosiduronic acid	CFN95321	107783-53-9	C₄₆H₇₄O₁₉ = 931.1	20mg	QQ客服：2056216494
原薯蓣皂苷; Protodioscin	CFN99517	55056-80-9	C₅₁H₈₄O₂₂ = 1049.21	20mg	QQ客服：1457312923
甲基原薯蓣皂苷; Methyl protodioscin	CFN99585	54522-52-0	C₅₂H₈₆O₂₂ = 1063.23	20mg	QQ客服：2056216494
原翠雀皂苷; Protodeltonin	CFN93008	94992-08-2	C₅₁H₈₄O₂₃ = 1065.21	5mg	QQ客服：2056216494
伪原纤细薯蓣皂苷; Pseudoprotogracillin	CFN93038	637349-03-2	C₅₁H₈₂O₂₂ = 1047.2	5mg	QQ客服：215959384
原纤细薯蓣皂苷; Protogracillin	CFN93054	54848-30-5	C₅₁H₈₄O₂₃ = 1065.21	5mg	QQ客服：215959384
甲基原纤细薯蓣皂苷; Methyl protogracillin	CFN80084	54522-53-1	C₅₂H₈₆O₂₃ = 1078.55	10mg	QQ客服：1457312923
重楼皂苷G; Polyphyllin G	CFN99955	76296-75-8	C₅₁H₈₄O₂₂ = 1049.22	5mg	QQ客服：3257982914
原皂苷Pa; Parisaponin I	CFN90702	561007-63-4	C₅₀H₈₂O₂₂ = 1034.0	5mg	QQ客服：2056216494

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	0.9531 mL	4.7654 mL	9.5309 mL	19.0618 mL	23.8272 mL
5 mM	0.1906 mL	0.9531 mL	1.9062 mL	3.8124 mL	4.7654 mL
10 mM	0.0953 mL	0.4765 mL	0.9531 mL	1.9062 mL	2.3827 mL
50 mM	0.0191 mL	0.0953 mL	0.1906 mL	0.3812 mL	0.4765 mL
100 mM	0.0095 mL	0.0477 mL	0.0953 mL	0.1906 mL	0.2383 mL

重楼皂苷G

Polyphyllin G

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