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  • 白花前胡乙素

    Praeruptorin B

    白花前胡乙素
    产品编号 CFN98140
    CAS编号 81740-07-0
    分子式 = 分子量 C24H26O7 = 426.46
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The roots of Peucedanum praeruptorum Dunn.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    白花前胡乙素 CFN98140 81740-07-0 1mg QQ客服:1413575084
    白花前胡乙素 CFN98140 81740-07-0 5mg QQ客服:1413575084
    白花前胡乙素 CFN98140 81740-07-0 10mg QQ客服:1413575084
    白花前胡乙素 CFN98140 81740-07-0 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • The Australian National University (Australia)
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  • Deutsches Krebsforschungszentrum (Germany)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • UDC.2020, 19(4).
  • Int J Mol Med.2019, 43(6):2516-2522
  • J Bone Miner Res.2017, 32(12):2415-2430
  • J Nat Med.2020, 74(3):550-560.
  • J Chromatogr B Analyt Technol Biomed Life Sci. 2017, 1064:115-123
  • Food Engineering Progress2019, 23(3)209-216
  • Integr Med Res.2021, 10(3):100723.
  • Appl. Sci.2021, 11(19),9343.
  • Phytother Res.2018, 32(12):2551-2559
  • J Hematol Oncol.2018, 11(1):112
  • Biomed Pharmacother.2020, 128:110318.
  • Life Sci.2018, 209:498-506
  • Green Chemistry2021, ISSUE 2.
  • Int J Biol Macromol.2021, 199:189-200.
  • JPC-Journal of Planar Chromatography 2017, 30(4)
  • Food Chem.2020, 332:127412
  • Journal of Ginseng Research2021, 25 November
  • Nutrients.2018, 10(12):E1998
  • Toxicol Appl Pharmacol.2022, 434:115815.
  • Semyung University2017, 149407
  • Aquaculture2019, 510:392-399
  • Chin. Med.J.Res. Prac.2017, 31(4)
  • Phytomedicine.2015, 22(14):1262-8
  • ...
  • 生物活性
    Description: Praeruptorin B has significant important phase II drug-metabolizing enzymes uridine 5'-diphospho-glucuronosyltransferase (UGTs) isoforms inhibition activity. Praeruptorin B and praeruptorin A have LC 50 values of 34.5 and121.2 ug/ml, respectively, in Artemia salina test .
    Targets: Antifection | UGT
    In vitro:
    Phytother Res. 2016 Nov;30(11):1872-1878.
    The Inhibition of UDP-Glucuronosyltransferase (UGT) Isoforms by Praeruptorin A and B.[Pubmed: 27534594 ]
    Praeruptorin A (PA) and praeruptorin B (PB) are two important compounds isolated from Bai-hua Qian-hu and have been reported to exert multiple biochemical and pharmacological activities. The present study aims to determine the inhibition of PA and PB on the activity of important phase II drug-metabolizing enzymes uridine 5'-diphospho-glucuronosyltransferase (UGTs) isoforms.
    METHODS AND RESULTS:
    In vitro UGT incubation system was used to determine the inhibition potential of PA and PB on the activity of various UGT isoforms. In silico docking was performed to explain the inhibition difference between PA and PB towards the activity of UGT1A6. Inhibition behaviour was determined, and in vitro-in vivo extrapolation was performed by using the combination of in vitro inhibition kinetic parameter (Ki ) and in vivo exposure level of PA. Praeruptorin A (100 μM) exhibited the strongest inhibition on the activity of UGT1A6 and UGT2B7, with 97.8% and 90.1% activity inhibited by 100 μM of PA, respectively. In silico docking study indicates the significant contribution of hydrogen bond interaction towards the stronger inhibition of PA than PB towards UGT1A6. Praeruptorin A noncompetitively inhibited the activity of UGT1A6 and competitively inhibited the activity of UGT2B7. The inhibition kinetic parameter (Ki ) of PA towards UGT1A6 and UGT2B7 was calculated to be 1.2 and 3.3 μM, respectively. The [I]/Ki value was calculated to be 15.8 and 5.8 for the inhibition of PA on UGT1A6 and UGT2B7, indicating high inhibition potential of PA towards these two UGT isoforms in vivo.
    CONCLUSIONS:
    Therefore, closely monitoring the interaction between PA and drugs mainly undergoing UGT1A6 or UGT2B7-catalyzed metabolism is very necessary.
    Phytother Res . 2016 Nov;30(11):1872-1878.
    The Inhibition of UDP-Glucuronosyltransferase (UGT) Isoforms by Praeruptorin A and B[Pubmed: 27534594]
    Abstract Praeruptorin A (PA) and B (PB) are two important compounds isolated from Bai-hua Qian-hu and have been reported to exert multiple biochemical and pharmacological activities. The present study aims to determine the inhibition of PA and PB on the activity of important phase II drug-metabolizing enzymes uridine 5'-diphospho-glucuronosyltransferase (UGTs) isoforms. In vitro UGT incubation system was used to determine the inhibition potential of PA and PB on the activity of various UGT isoforms. In silico docking was performed to explain the inhibition difference between PA and PB towards the activity of UGT1A6. Inhibition behaviour was determined, and in vitro-in vivo extrapolation was performed by using the combination of in vitro inhibition kinetic parameter (Ki ) and in vivo exposure level of PA. Praeruptorin A (100 μM) exhibited the strongest inhibition on the activity of UGT1A6 and UGT2B7, with 97.8% and 90.1% activity inhibited by 100 μM of PA, respectively. In silico docking study indicates the significant contribution of hydrogen bond interaction towards the stronger inhibition of PA than PB towards UGT1A6. Praeruptorin A noncompetitively inhibited the activity of UGT1A6 and competitively inhibited the activity of UGT2B7. The inhibition kinetic parameter (Ki ) of PA towards UGT1A6 and UGT2B7 was calculated to be 1.2 and 3.3 μM, respectively. The [I]/Ki value was calculated to be 15.8 and 5.8 for the inhibition of PA on UGT1A6 and UGT2B7, indicating high inhibition potential of PA towards these two UGT isoforms in vivo. Therefore, closely monitoring the interaction between PA and drugs mainly undergoing UGT1A6 or UGT2B7-catalyzed metabolism is very necessary. Copyright © 2016 John Wiley & Sons, Ltd. Keywords: Praeruptorin A; Praeruptorin B; UDP-glucuronosyltransferases (UGTs); drug-drug interaction (DDI).
    In vivo:
    Farmaco. 2001 May-Jul;56(5-7):417-20.
    Isolation of praeruptorins A and B from Peucedanum praeruptorum Dunn. and their general pharmacological evaluation in comparison with extracts of the drug.[Pubmed: 11482769]
    The root of Peucedanum praeruptorum Dunn. was extracted with solvents at different polarity obtaining three chemical fractions: aqueous (H2O), n-butanol (BuOH) and ethyl acetate (AcOEt).
    METHODS AND RESULTS:
    From AcOEt praeruptorin A and praeruptorin B were isolated by column chromatography on silica gel, using toluene/ethyl acetate as eluent, and identified by 1H and 13C NMR analysis. The extracts and the praeruptorins were tested for gross behavioural effects and acute toxicity in mice; the cytotoxicity on Artemia salina Leach and the antimicrobial activity were also evaluated. None of the tested substances evoked behavioural effects or acute toxicity after oral administration in mice; delayed mortality was observed with AcOEt and praeruptorin A only after intraperitoneal administration of high doses (1 g/kg). In Artemia salina test AcOEt, and praeruptorins A and praeruptorin B had LC50 values of 40.2, 121.2 and 34.5 microg/ml, respectively.
    CONCLUSIONS:
    AcOEt and praeruptorin A showed antimicrobial activity on Streptococcus agalactiae; their MIC values were 250 and 100 microg/ml, respectively.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3449 mL 11.7244 mL 23.4489 mL 46.8977 mL 58.6221 mL
    5 mM 0.469 mL 2.3449 mL 4.6898 mL 9.3795 mL 11.7244 mL
    10 mM 0.2345 mL 1.1724 mL 2.3449 mL 4.6898 mL 5.8622 mL
    50 mM 0.0469 mL 0.2345 mL 0.469 mL 0.938 mL 1.1724 mL
    100 mM 0.0234 mL 0.1172 mL 0.2345 mL 0.469 mL 0.5862 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    白花前胡甲素; Praeruptorin A CFN98139 73069-25-7 C21H22O7 = 386.40 20mg QQ客服:1148253675
    白花前胡乙素; Praeruptorin B CFN98140 81740-07-0 C24H26O7 = 426.46 10mg QQ客服:2159513211
    白花前胡香豆精I; Peucedanocoumarin I CFN92518 130464-55-0 C21H24O7 = 388.4 5mg QQ客服:1148253675
    白花前胡香豆精II; Peucedanocoumarin II CFN92519 130464-56-1 C21H22O7 = 386.4 5mg QQ客服:3257982914
    白花前胡香豆精III; Peucedanocoumarin III CFN92560 130464-57-2 C21H22O7 = 386.4 5mg QQ客服:1413575084
    反式-(-)-凯林内酯 ; trans-Khellactone CFN96611 23458-04-0 C14H14O5 = 262.26 5mg QQ客服:2932563308
    反式-甲基凯诺内酯; trans-Methylkhellactone CFN96610 23733-92-8 C15H16O5 = 276.28 5mg QQ客服:2159513211
    反式-3'-O-苯甲酰-4'-O-甲基凯诺内酯; trans-3'-O-Benzoyl-4'-O-methylkhellactone CFN96612 23733-95-1 C22H20O6 = 380.39 5mg QQ客服:215959384

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