冬凌草乙素

Ponicidin

	产品编号	CFN92259
	CAS编号	52617-37-5
	分子式 = 分子量	C₂₀H₂₆O₆ = 362.4
	产品纯度	>=98%
	物理属性	Cryst.
	化合物类型	Diterpenoids
	植物来源	The herbs of Isodon japonicus
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产品名称	产品编号	CAS编号	包装	QQ客服
冬凌草乙素	CFN92259	52617-37-5	1mg	QQ客服：215959384
冬凌草乙素	CFN92259	52617-37-5	5mg	QQ客服：215959384
冬凌草乙素	CFN92259	52617-37-5	10mg	QQ客服：215959384
冬凌草乙素	CFN92259	52617-37-5	20mg	QQ客服：215959384

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Description:

Ponicidin has anti-leukemia, immunoregulatory and anti-inflammatory functions, it also has anti-viral function especially in the upper respiratory tract infection. Ponicidin has anti-cancer activity against gastric carcinoma and lung cancer; can inhibit growth and induce apoptosis of gastric carcinoma cell line MKN28, via the signaling pathway regulated by Janus kinase 2 (JAK2) and signal transducers and activators of transcription 3 (STAT3).

Targets:

ROS | Bcl-2/Bax | Caspase | JAK | STAT | PI3K | Akt | ERK | JNK | HSV | PARP

In vitro:

Zhongguo Zhong Yao Za Zhi. 2010 Aug;35(16):2161-5.

Apoptosis inducing effect of ponicidin in leukemia K562 cells and its mechanisms of action[Pubmed: 21046753]

To investigate the apoptosis inducing effects of Ponicidin (PON) on leukemic K562 cells and its mechanisms of action.
METHODS AND RESULTS:
K562 cells in culture medium in vitro were given different concentrations of Ponicidin (10-50 micromol x L(-1)) for 24, 48 and 72 h. The inhibitory rate of the cells was measured by MTT assay, cell apoptotic rates were detected by flow cytometry (FCM) using Annexin V staining after K562 cells were treated with different concentrations of Ponicidin for 72 hours, and cell morphology was observed by Wright-Giemsa staining. Ponicidin (over 30 micromol x L(-1)) could inhibit the growth of K562 cells in both time- and dose-dependent manner. FCM analysis revealed that apoptotic cells were gradually increased in a dose-dependent manner after treatment for 72 hours, and that marked morphological changes of cell apoptosis such as condensation of chromatin was clearly observed by Wright-Giemsa staining after treatment by 50 micromol x L(-1) Ponicidin. Furthermore, Western blotting also showed that expression of p-AKT and p-P85 in PI3K/AKT signaling pathways was downregulated dramatically whereas the expression of p-P38 as well as p-ERK and p-JNK remained unchanged after the cells were treated by PON for 48 h.
CONCLUSIONS:
The results demonstrate that Ponicidin exhibits in vitro anti-leukemia effect by induction of apoptosis in K562 cells, and that Ponicidin induced apoptosis in K562 cells mainly related to activation of caspase-3 as well as inactivation of PI3K/AKT signaling pathway via down regulation of the expression of p-AKT and p-P85 protein levels. These results provide strong laboratory evidence for further anti-leukemia trials of Ponicidin.

Int J Mol Sci. 2008 Nov;9(11):2265-77.

Ponicidin inhibits monocytic leukemia cell growth by induction of apoptosis.[Pubmed: 19330074]

In this study two monocytic leukemia cell lines, U937 and THP-1 cells, were used to investigate the anti-proliferation effects caused by Ponicidin.
METHODS AND RESULTS:
Cell viability was measured by an MTT assay. Cell apoptosis was assessed by flow cytometry as well as DNA fragmentation analysis. Cell morphology was observed using an inverted microscope and Hoechst 33258 staining. RT-PCR and Western blot analysis were used to detect survivin as well as Bax and Bcl-2 expressions after the cells were treated with different concentrations of Ponicidin. The results revealed that Ponicidin could inhibit the growth of U937 and THP-1 cells significantly by induction of apoptosis. The suppression was in both time- and dose-dependent manner. Marked morphological changes of cell apoptosis were observed clearly after the cells were treated with Ponicidin for 48 approximately 72 h. RT-PCR and Western blot analysis demonstrated that both survivin and Bcl-2 expressions were down-regulated remarkably while Bax expression remained constant before and after apoptosis occurred.
CONCLUSIONS:
We therefore conclude that Ponicidin has significant anti-proliferation effects by inducing apoptosis on leukemia cells in vitro, downregulation of survivin as well as Bcl-2 expressions may be the important apoptosis inducing mechanisms. The results suggest that Ponicidin may serve as potential therapeutic agent for leukemia.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
冬凌草甲素; Oridonin	CFN99164	28957-04-2	C₂₀H₂₈O₆ = 364.43	20mg	QQ客服：1413575084
疏展香茶菜宁A; Effusanin A	CFN98377	30220-43-0	C₂₀H₂₈O₅ = 348.4	5mg	QQ客服：2056216494
疏展香茶菜宁B; Effusanin B	CFN92434	76470-16-1	C₂₂H₃₀O₆ = 390.5	5mg	QQ客服：215959384
Lasiodin; Lasiodin	CFN92430	28957-08-6	C₂₂H₃₀O₇ = 406.5	5mg	QQ客服：1457312923
长管贝壳杉素E; Longikaurin E	CFN97266	77949-42-9	C₂₂H₃₀O₆ = 390.5	5mg	QQ客服：2159513211
疏展香茶菜宁E; Effusanin E	CFN92262	76470-15-0	C₂₀H₂₈O₆ = 364.4	5mg	QQ客服：3257982914
Taibaihenryiins A; Taibaihenryiins A	CFN92314	398129-59-4	C₂₂H₃₀O₇ = 406.5	5mg	QQ客服：2159513211
希柯勘宁; Shikokianin	CFN92311	24267-69-4	C₂₄H₃₂O₈ = 448.5	5mg	QQ客服：2159513211
旱生香茶菜素G; Xerophilusin G	CFN98386	304642-94-2	C₂₂H₃₀O₈ = 422.5	5mg	QQ客服：1413575084
Trichokaurin; Trichokaurin	CFN97984	23811-50-9	C₂₄H₃₄O₇ = 434.5	5mg	QQ客服：1413575084

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.7594 mL	13.7969 mL	27.5938 mL	55.1876 mL	68.9845 mL
5 mM	0.5519 mL	2.7594 mL	5.5188 mL	11.0375 mL	13.7969 mL
10 mM	0.2759 mL	1.3797 mL	2.7594 mL	5.5188 mL	6.8985 mL
50 mM	0.0552 mL	0.2759 mL	0.5519 mL	1.1038 mL	1.3797 mL
100 mM	0.0276 mL	0.138 mL	0.2759 mL	0.5519 mL	0.6898 mL

冬凌草乙素

Ponicidin

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