冬凌草乙素

Ponicidin

	产品编号	CFN92259
	CAS编号	52617-37-5
	分子式 = 分子量	C₂₀H₂₆O₆ = 362.4
	产品纯度	>=98%
	物理属性	Cryst.
	化合物类型	Diterpenoids
	植物来源	The herbs of Isodon japonicus
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

提供自定义包装

产品名称	产品编号	CAS编号	包装	QQ客服
冬凌草乙素	CFN92259	52617-37-5	1mg	QQ客服：2159513211
冬凌草乙素	CFN92259	52617-37-5	5mg	QQ客服：2159513211
冬凌草乙素	CFN92259	52617-37-5	10mg	QQ客服：2159513211
冬凌草乙素	CFN92259	52617-37-5	20mg	QQ客服：2159513211

存储与注意事项

1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。

2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。通常，这些可用于长达两周。使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。

3. 需要更多关于溶解度，使用和处理的建议？请发送电子邮件至：service@chemfaces.com

订购流程

1. 在线订购

请联系我们QQ客服

2. 电话订购

请拨打电话：
027-84237683 或 027-84237783

3. 邮件或传真订购

发送电子邮件到: manager@chemfaces.com 或
发送传真到：027-84254680

提供订购信息

为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。

1. 产品编号（CAS No.或产品名称）

2. 发货地址

3. 联系方法 (联系人，电话）

4. 开票抬头 (如果需要发票的客户）

5. 发票地址（发货地址与发票地址不同）

发货时间

1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。

2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。

3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。

Description:

Ponicidin has anti-leukemia, immunoregulatory and anti-inflammatory functions, it also has anti-viral function especially in the upper respiratory tract infection. Ponicidin has anti-cancer activity against gastric carcinoma and lung cancer; can inhibit growth and induce apoptosis of gastric carcinoma cell line MKN28, via the signaling pathway regulated by Janus kinase 2 (JAK2) and signal transducers and activators of transcription 3 (STAT3).

Targets:

ROS | Bcl-2/Bax | Caspase | JAK | STAT | PI3K | Akt | ERK | JNK | HSV | PARP

In vitro:

Zhongguo Zhong Yao Za Zhi. 2010 Aug;35(16):2161-5.

Apoptosis inducing effect of ponicidin in leukemia K562 cells and its mechanisms of action[Pubmed: 21046753]

To investigate the apoptosis inducing effects of Ponicidin (PON) on leukemic K562 cells and its mechanisms of action.
METHODS AND RESULTS:
K562 cells in culture medium in vitro were given different concentrations of Ponicidin (10-50 micromol x L(-1)) for 24, 48 and 72 h. The inhibitory rate of the cells was measured by MTT assay, cell apoptotic rates were detected by flow cytometry (FCM) using Annexin V staining after K562 cells were treated with different concentrations of Ponicidin for 72 hours, and cell morphology was observed by Wright-Giemsa staining. Ponicidin (over 30 micromol x L(-1)) could inhibit the growth of K562 cells in both time- and dose-dependent manner. FCM analysis revealed that apoptotic cells were gradually increased in a dose-dependent manner after treatment for 72 hours, and that marked morphological changes of cell apoptosis such as condensation of chromatin was clearly observed by Wright-Giemsa staining after treatment by 50 micromol x L(-1) Ponicidin. Furthermore, Western blotting also showed that expression of p-AKT and p-P85 in PI3K/AKT signaling pathways was downregulated dramatically whereas the expression of p-P38 as well as p-ERK and p-JNK remained unchanged after the cells were treated by PON for 48 h.
CONCLUSIONS:
The results demonstrate that Ponicidin exhibits in vitro anti-leukemia effect by induction of apoptosis in K562 cells, and that Ponicidin induced apoptosis in K562 cells mainly related to activation of caspase-3 as well as inactivation of PI3K/AKT signaling pathway via down regulation of the expression of p-AKT and p-P85 protein levels. These results provide strong laboratory evidence for further anti-leukemia trials of Ponicidin.

Int J Mol Sci. 2008 Nov;9(11):2265-77.

Ponicidin inhibits monocytic leukemia cell growth by induction of apoptosis.[Pubmed: 19330074]

In this study two monocytic leukemia cell lines, U937 and THP-1 cells, were used to investigate the anti-proliferation effects caused by Ponicidin.
METHODS AND RESULTS:
Cell viability was measured by an MTT assay. Cell apoptosis was assessed by flow cytometry as well as DNA fragmentation analysis. Cell morphology was observed using an inverted microscope and Hoechst 33258 staining. RT-PCR and Western blot analysis were used to detect survivin as well as Bax and Bcl-2 expressions after the cells were treated with different concentrations of Ponicidin. The results revealed that Ponicidin could inhibit the growth of U937 and THP-1 cells significantly by induction of apoptosis. The suppression was in both time- and dose-dependent manner. Marked morphological changes of cell apoptosis were observed clearly after the cells were treated with Ponicidin for 48 approximately 72 h. RT-PCR and Western blot analysis demonstrated that both survivin and Bcl-2 expressions were down-regulated remarkably while Bax expression remained constant before and after apoptosis occurred.
CONCLUSIONS:
We therefore conclude that Ponicidin has significant anti-proliferation effects by inducing apoptosis on leukemia cells in vitro, downregulation of survivin as well as Bcl-2 expressions may be the important apoptosis inducing mechanisms. The results suggest that Ponicidin may serve as potential therapeutic agent for leukemia.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
毛叶香茶菜丁素; Odonicin	CFN98822	51419-51-3	C₂₄H₃₀O₇ = 430.5	5mg	QQ客服：2056216494
Hebeirubescensin H; Hebeirubescensin H	CFN96853	887333-30-4	C₂₀H₂₈O₇ = 380.43	5mg	QQ客服：2159513211
牛尾草素 F; Rabdoternin F	CFN96855	155977-87-0	C₂₁H₃₀O₇ = 394.46	5mg	QQ客服：1413575084
冬凌草乙素; Ponicidin	CFN92259	52617-37-5	C₂₀H₂₆O₆ = 362.4	5mg	QQ客服：2056216494
Rabdoserrin A; Rabdoserrin A	CFN91931	96685-01-7	C₂₀H₂₆O₅ = 346.42	5mg	QQ客服：2159513211
尾叶香茶菜丙素; Kamebakaurin	CFN91932	73981-34-7	C₂₀H₃₀O₅ = 350.45	5mg	QQ客服：2159513211
冬凌草甲素; Oridonin	CFN99164	28957-04-2	C₂₀H₂₈O₆ = 364.43	20mg	QQ客服：215959384
疏展香茶菜宁A; Effusanin A	CFN98377	30220-43-0	C₂₀H₂₈O₅ = 348.4	5mg	QQ客服：2159513211
疏展香茶菜宁B; Effusanin B	CFN92434	76470-16-1	C₂₂H₃₀O₆ = 390.5	5mg	QQ客服：215959384
Lasiodin; Lasiodin	CFN92430	28957-08-6	C₂₂H₃₀O₇ = 406.5	5mg	QQ客服：1457312923

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.7594 mL	13.7969 mL	27.5938 mL	55.1876 mL	68.9845 mL
5 mM	0.5519 mL	2.7594 mL	5.5188 mL	11.0375 mL	13.7969 mL
10 mM	0.2759 mL	1.3797 mL	2.7594 mL	5.5188 mL	6.8985 mL
50 mM	0.0552 mL	0.2759 mL	0.5519 mL	1.1038 mL	1.3797 mL
100 mM	0.0276 mL	0.138 mL	0.2759 mL	0.5519 mL	0.6898 mL

冬凌草乙素

Ponicidin

信息支持

联系方式