尾叶香茶菜丙素

Kamebakaurin

	产品编号	CFN91932
	CAS编号	73981-34-7
	分子式 = 分子量	C₂₀H₃₀O₅ = 350.45
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Diterpenoids
	植物来源	The herbs of Rabdosia serra
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
尾叶香茶菜丙素	CFN91932	73981-34-7	1mg	QQ客服：2159513211
尾叶香茶菜丙素	CFN91932	73981-34-7	5mg	QQ客服：2159513211
尾叶香茶菜丙素	CFN91932	73981-34-7	10mg	QQ客服：2159513211
尾叶香茶菜丙素	CFN91932	73981-34-7	20mg	QQ客服：2159513211

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Universidade do Porto (Portugal)

Mendel University in Brno (Czech Republic)

Technical University of Denmark (Denmark)

Research Unit Molecular Epigenetics (MEG) (Germany)

University of Illinois (USA)

Medical University of Gdansk (Poland)

Florida International University (USA)

Tokyo Woman's Christian University (Japan)

University of Illinois at Chicago (USA)

Charles Sturt University (Denmark)

University of Hawaii Cancer Center (USA)

Anna University (India)

Sanford Burnham Medical Research Institute (USA)

Heinrich-Heine-University Düsseldorf (Germany)

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Description:

Kamebakaurin has anti-cancer and anti-inflammatory activities through direct inhibition of DNA-binding activity of nuclear factor-kappa B (NF-κB) p50; it has anti-neuroinflammatory activity via inhibition of c-Jun NH₂-terminal kinase and p38 mitogen-activated protein kinase pathway in activated microglial cells. Kamebakaurin inhibits the expression of hypoxia-inducible factor-1α and its target genes to confer antitumor activity. Kamebakaurin also has the ability to protect the liver from APAP-induced hepatotoxicity, presumably by both inhibiting the inflammatory response and oxidative stress.

Targets:

HIF | Topoisomerase | VEGFR | NF-kB | JNK | p38MAPK | IkB | NO | COX | NOS | IKK

In vitro:

J Pharmacol Sci. 2011;116(3):296-308.

Anti-neuroinflammatory activity of Kamebakaurin from Isodon japonicus via inhibition of c-Jun NH₂-terminal kinase and p38 mitogen-activated protein kinase pathway in activated microglial cells.[Pubmed: 21705843]

Compelling evidence supports the notion that the majority of neurodegenerative diseases are associated with microglia-mediated neuroinflammation. Therefore, quelling of microglial activation may lead to neuronal cell survival.
METHODS AND RESULTS:
The present study investigated the effects of Kamebakaurin (KMBK), a kaurane diterpene isolated from Isodon japonicus HARA (Labiatae), on the production of pro-inflammatory mediators in lipopolysaccharide (LPS)-stimulated cytotoxicity in rat primary microglial cultures and the BV-2 cell line. KMBK significantly inhibited the LPS-induced production of nitric oxide (NO) in a concentration-dependent fashion in activated microglial cells. The mRNA and protein levels of inducible nitric oxide synthase (iNOS) and cyclooxycenase-2 (COX-2) were also decreased dose-dependently. Furthermore KMBK inhibited the JNK and p38 mitogen-activated protein kinases (MAPKs) in LPS-stimulated BV-2 microglial cells.
CONCLUSIONS:
Considering the results obtained, the present study authenticated the potential benefits of KMBK as a therapeutic target in ameliorating microglia-mediated neuroinflammatory diseases.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
毛叶香茶菜素; Maoyerabdosin	CFN96034	90468-72-7	C₂₄H₃₆O₉ = 468.5	5mg	QQ客服：3257982914
毛萼乙素; Eriocalyxin B	CFN97402	84745-95-9	C₂₀H₂₄O₅ = 344.4	5mg	QQ客服：2159513211
毛萼晶乙; Maoecrystal B	CFN97546	96850-29-2	C₂₂H₂₈O₆ = 388.5	5mg	QQ客服：1457312923
毛叶香茶菜丁素; Odonicin	CFN98822	51419-51-3	C₂₄H₃₀O₇ = 430.5	5mg	QQ客服：215959384
Hebeirubescensin H; Hebeirubescensin H	CFN96853	887333-30-4	C₂₀H₂₈O₇ = 380.43	5mg	QQ客服：1413575084
牛尾草素 F; Rabdoternin F	CFN96855	155977-87-0	C₂₁H₃₀O₇ = 394.46	5mg	QQ客服：3257982914
冬凌草乙素; Ponicidin	CFN92259	52617-37-5	C₂₀H₂₆O₆ = 362.4	5mg	QQ客服：3257982914
Rabdoserrin A; Rabdoserrin A	CFN91931	96685-01-7	C₂₀H₂₆O₅ = 346.42	5mg	QQ客服：1457312923
尾叶香茶菜丙素; Kamebakaurin	CFN91932	73981-34-7	C₂₀H₃₀O₅ = 350.45	5mg	QQ客服：2056216494
冬凌草甲素; Oridonin	CFN99164	28957-04-2	C₂₀H₂₈O₆ = 364.43	20mg	QQ客服：215959384

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.8535 mL	14.2674 mL	28.5347 mL	57.0695 mL	71.3369 mL
5 mM	0.5707 mL	2.8535 mL	5.7069 mL	11.4139 mL	14.2674 mL
10 mM	0.2853 mL	1.4267 mL	2.8535 mL	5.7069 mL	7.1337 mL
50 mM	0.0571 mL	0.2853 mL	0.5707 mL	1.1414 mL	1.4267 mL
100 mM	0.0285 mL	0.1427 mL	0.2853 mL	0.5707 mL	0.7134 mL