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  • 匹西狄醇A

    Piscidinol A

    匹西狄醇A
    产品编号 CFN99017
    CAS编号 100198-09-2
    分子式 = 分子量 C30H50O4 = 474.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The barks of Phellodendron chinense
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    匹西狄醇A CFN99017 100198-09-2 1mg QQ客服:3257982914
    匹西狄醇A CFN99017 100198-09-2 5mg QQ客服:3257982914
    匹西狄醇A CFN99017 100198-09-2 10mg QQ客服:3257982914
    匹西狄醇A CFN99017 100198-09-2 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • MTT Agrifood Research Finland (Finland)
  • University of Hertfordshire (United Kingdom)
  • Hamdard University (India)
  • Sri Ramachandra University (India)
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  • University of Eastern Finland (Finland)
  • Universiti Putra Malaysia(UPM) (Malaysia)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Plant Pathology2022, 10.1111:ppa.13651.
  • Nat Prod Sci.2014, 20(3):182-190
  • Pharmaceuticals (Basel).2022, 15(8):982.
  • Cell Signal.2022, 99:110433.
  • Food Funct.2022, 13(13):6923-6933.
  • Research on Crops.2017, 18(2)
  • J Ethnopharmacol.2022, 289:115018.
  • Molecules.2021, 26(8):2161.
  • J Control Release.2021, 336:159-168.
  • Int J Immunopathol Pharmacol.2019, 33:2058738419857537
  • Nature Ecology & Evolution2020, doi: 10.1038
  • Vietnam J. Chem.2023, 61(3),308-317
  • Front Pharmacol.2021, 12:762829.
  • Food Sci Biotechnol.2023, 32(9):1215-1223.
  • Foods.2021, 10(6):1378.
  • J Korean Soc Food Sci Nutr2023, 52(11):1101-1110
  • Cell Mol Biol(Noisy-le-grand)2019, 65(7):77-83
  • Molecules.2021, 26(4):817.
  • J Chromatogr Sci.2015, 53(5):824-9
  • ACS Synth Biol.2020, 9(9):2282-2290.
  • Phytochemistry.2017, 141:162-170
  • Antioxidants (Basel).2019, 8(8):E307
  • Sci Rep.2017, 7:467-479
  • ...
  • 生物活性
    Description: Piscidinol A is toxic against the 4T1 and HEp2 cancer cell lines, the IC50 of 8.0 ± 0.03 and 8.4 ± 0.01 uM, respectively. It can inhibit NO production in mouse peritoneal macrophages with inhibitory ratios ranging from 39.8±7.7 to 68.2±4.5%.
    Targets: NO
    In vitro:
    Chem Biodivers. 2013 Apr;10(4):695-702.
    Tirucallane triterpenoids from the stems of Brucea mollis.[Pubmed: 23576355]

    METHODS AND RESULTS:
    Three new tirucallane triterpenoids, brumollisols A-C (1-3, resp.), together with five known analogues, (23R,24S)-23,24,25-trihydroxytirucall-7-ene-3,6-dione (4), Piscidinol A (5), 24-epiPiscidinol A (6), 21α-methylmelianodiol (7), and 21β-methylmelianodiol (8), were isolated from an EtOH extract of the stems of Brucea mollis. Their structures were elucidated by means of spectroscopic methods including 1D- and 2D-NMR techniques and mass spectrometry.
    CONCLUSIONS:
    In the in vitro assays, compound 6 exhibited significant cytotoxic activity against A549 and BGC-823 cancer cells with IC50 values of 1.16 and 3.01 μM, respectively. At a concentration of 10 μM, compounds 1-5, 7, and 8 were found to inhibit NO production in mouse peritoneal macrophages with inhibitory ratios ranging from 39.8±7.7 to 68.2±4.5%.
    J Ethnopharmacol. 2015 Nov 4;174:419-25.
    Antiplasmodial and cytotoxic activities of the constituents of Turraea robusta and Turraea nilotica.[Pubmed: 26320684 ]
    Turraea robusta and Turraea nilotica are African medicinal plants used for the treatment of a wide variety of diseases, including malaria. The genus Turraea is rich in limonoids and other triterpenoids known to possess various biological activities.
    METHODS AND RESULTS:
    From the stem bark of T. robusta six compounds, and from various parts of T. nilotica eleven compounds were isolated by the use of a combination of chromatographic techniques. The structures of the isolated compounds were elucidated using NMR and MS, whilst the relative configuration of one of the isolated compounds, toonapubesin F, was established by X-ray crystallography. The antiplasmodial activities of the crude extracts and the isolated constituents against the D6 and W2 strains of Plasmodium falciparum were determined using the semiautomated micro dilution technique that measures the ability of the extracts to inhibit the incorporation of (G-(3)H, where G is guanine) hypoxanthine into the malaria parasite. The cytotoxicity of the crude extracts and their isolated constituents was evaluated against the mammalian cell lines African monkey kidney (vero), mouse breast cancer (4T1) and human larynx carcinoma (HEp2). The extracts showed good to moderate antiplasmodial activities, where the extract of the stem bark of T. robusta was also cytotoxic against the 4T1 and the HEp2 cells (IC50<10 μg/ml). The compounds isolated from these extracts were characterized as limonoids, protolimonoids and phytosterol glucosides. These compounds showed good to moderate activities with the most active one being azadironolide, IC50 2.4 ± 0.03 μM and 1.1 ± 0.01 μM against the D6 and W2 strains of Plasmodium falciparum, respectively; all other compounds possessed IC50 14.4-40.5 μM. None of the compounds showed significant cytotoxicity against vero cells, yet four of them were toxic against the 4T1 and HEp2 cancer cell lines with piscidinol A having IC50 8.0 ± 0.03 and 8.4 ± 0.01 μM against the 4T1 and HEp2 cells, respectively. Diacetylation of piscidinol A resulted in reduced cytotoxicity.
    CONCLUSIONS:
    From the medicinal plants T. robusta and T. nilotica, twelve compounds were isolated and characterized; two of the isolated compounds, namely 11-epi-toonacilin and azadironolide showed good antiplasmodial activity with the highest selectivity indices.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1066 mL 10.533 mL 21.0659 mL 42.1319 mL 52.6648 mL
    5 mM 0.4213 mL 2.1066 mL 4.2132 mL 8.4264 mL 10.533 mL
    10 mM 0.2107 mL 1.0533 mL 2.1066 mL 4.2132 mL 5.2665 mL
    50 mM 0.0421 mL 0.2107 mL 0.4213 mL 0.8426 mL 1.0533 mL
    100 mM 0.0211 mL 0.1053 mL 0.2107 mL 0.4213 mL 0.5266 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3β-乙酰氧基-7,25-甘遂二烯-24(R)-醇; 3Beta-acetoxy-eupha-7,25-dien-24(R)-ol CFN90369 1352001-09-2 C32H52O3 = 484.75 5mg QQ客服:1413575084
    二氢尼洛替星; Dihydroniloticin CFN99253 115334-05-9 C30H50O3 = 458.7 5mg QQ客服:2159513211
    尼洛替星; Niloticin CFN99254 115404-57-4 C30H48O3 = 456.7 5mg QQ客服:3257982914
    24,25-环氧基甘遂-7-烯-3,23-二酮; 24,25-Epoxytirucall-7-en-3,23-dione CFN97458 890928-81-1 C30H46O3 = 454.7 5mg QQ客服:3257982914
    匹西狄醇A; Piscidinol A CFN99017 100198-09-2 C30H50O4 = 474.7 5mg QQ客服:2159513211
    黄柏呈; Phellochin CFN99252 115334-04-8 C31H52O4 = 488.8 5mg QQ客服:215959384
    乳香二烯酮酸, 熏陆香二烯酮酸; Masticadienolic acid CFN98707 472-30-0 C30H48O3 = 456.7 5mg QQ客服:2159513211
    (24Z)-3,4-开环甘遂-4(28),7,24-三烯-3,26-二酸; 3,4-Secotirucalla-4(28,7,24-triene-3),26-dioic acid CFN99671 159623-48-0 C30H46O4 = 470.7 5mg QQ客服:3257982914

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