| Description: |
Masticadienolic acid is a specific competitive inhibitor of secreted phospholipase A2, it not only protects the active site histidine from alkylation but also inhibits the action of secreted from pancreas, synovial fluid, and bee venom. Masticadienolic acid has anti-inflammatory activity, it shows effectiveness on the mouse ear inflammation induced by repeated applications of 12-0-tetradecanoylphorbol 13-acetate and on the phospholipase A2-induced foot paw edema.
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| Targets: |
NO |
| In vitro: |
| J Pharm Pharmacol. 2005 Sep;57(9):1087-91. | | Cytotoxic activity and effect on nitric oxide production of tirucallane-type triterpenes.[Pubmed: 16105229] |
METHODS AND RESULTS:
Hexane extract from the bark of Amphipterygium adstringens, as well as its principal constituents, masticadienonic acid and 3alpha-hydroxymasticadienolic acid, inhibited the growth of five human cancer cell lines. Derivatives of, namely 24,25 S-dihydromasticadienonic acid and masticadienolic acid, were also evaluated. The results showed that both and had greater activity than on colon cancer cell lines. The effects of on the production of nitric oxide (NO) from both resting and lipopolysaccharide-activated macrophages were determined.
CONCLUSIONS:
It was found that and caused an increase in NO release from resting macrophages; in lipopolysaccharide-activated macrophages, only and caused an increase in NO production. |
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| In vivo: |
| Planta Med. 2002 Apr;68(4):311-5. | | Anti-inflammatory triterpenes from Pistacia terebinthus galls.[Pubmed: 11988853] | From the galls of Pistacia terebinthus we obtained an extract that proved to be effective against chronic and acute inflammation.
METHODS AND RESULTS:
Now we report on the isolation and identification of three triterpenes: two tirucallane-type lanostanoids and one oleanane, which we have identified as masticadienonic acid (1), Masticadienolic acid (2), and morolic acid (3), respectively. All of them showed effectiveness on the mouse ear inflammation induced by repeated applications of 12-O-tetradecanoylphorbol 13-acetate and on the phospholipase A2-induced foot paw edema.
CONCLUSIONS:
The pharmacological activity of the compounds was ratified by a histological study of the ear samples. In addition, they inhibited leukotriene B4 production in rat polymorphonuclear leukocytes stimulated with calcium ionophore A 23187. |
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