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  • 红松内酯


    产品编号 CFN98404
    CAS编号 31685-80-0
    分子式 = 分子量 C21H30O4 = 346.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The barks of Biota orientalis L.
    产品名称 产品编号 CAS编号 包装 QQ客服
    红松内酯 CFN98404 31685-80-0 1mg QQ客服:2056216494
    红松内酯 CFN98404 31685-80-0 5mg QQ客服:2056216494
    红松内酯 CFN98404 31685-80-0 10mg QQ客服:2056216494
    红松内酯 CFN98404 31685-80-0 20mg QQ客服:2056216494
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  • 生物活性
    Description: Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, and could be used to treat neurodegenerative diseases. Pinusolide attenuates blockade of insulin signaling by enhancing IRS-1 tyrosine phosphorylation by the activating the AMPK pathway, indicates the targeting of AMPK represents a new therapeutic strategy for hyperglycemia-induced insulin resistance and type 2 diabetes.
    Targets: AMPK | LOX | Calcium Channel | JNK | ERK | p38MAPK | Caspase | PAFR
    In vitro:
    Br J Pharmacol. 2007 Jan;150(1):65-71.
    Pinusolide and 15-methoxypinusolidic acid attenuate the neurotoxic effect of staurosporine in primary cultures of rat cortical cells.[Pubmed: 17143305]
    Apoptosis is a fundamental process required for neuronal development but also occurs in most of the common neurodegenerative disorders. In an attempt to obtain an anti-apoptotic neuroprotective compound from natural products, we isolated the diterpenoids, pinusolide and 15-MPA, from B. orientalis and investigated their neuroprotective activity against staurosporine (STS) -induced neuronal apoptosis. In addition, we determined the anti-apoptotic mechanism of these compounds in rat cortical cells.
    Primary cultures of rat cortical cells injured by STS were used as an in vitro assay system. Cells were pretreated with pinusolide or 15-MPA before exposure to STS. Anti-apoptotic activities were evaluated by the measurement of cytoplasmic condensation and nuclear fragmentation. The levels of cellular peroxide, malondialdehyde (MDA) and [Ca(2+)]i, as well as the activities of superoxide dismutase (SOD) and caspase-3/7, were measured. Pinusolide and 15-MPA, at a concentration of 5.0 ìM, reduced the condensed nuclei and rise in [Ca(2+)]i that accompanies apoptosis induced by 100 nM STS. Pinusolide and 15-MPA also protected the cellular activity of SOD, an antioxidative enzyme reduced by STS insult. Furthermore, the overproduction of reactive oxygen species and lipid peroxidation induced by STS was significantly reduced in pinusolide and 15-MPA treated cells. In addition, pinusolide and 15-MPA inhibited STS-induced caspase-3/7 activation.
    These results show that pinusolide and 15-MPA protect neuronal cells from STS-induced apoptosis, probably by preventing the increase in [Ca(2+)]i and cellular oxidation caused by STS, and indicate that they could be used to treat neurodegenerative diseases.
    Planta Med. 1999 Feb;65(1):39-42.
    Pinusolide from the leaves of Biota orientalis as potent platelet activating factor antagonist.[Pubmed: 10083843]
    We investigated the effect of a new PAF antagonist Pinusolide, isolated from the leaves of Biota orientalis, on PAF-induced [3H]serotinin release from rabbit platelets, hypotension and vascular permeability.
    Pinusolide (IC50, about 5 x 10(-6) M) inhibited specifically [3H]serotinin release from rabbit platelets when stimulated with PAF (5 x 10(-8) M), but showed no effect when induced by ADP, collagen, and thrombin. It also inhibited PAF-induced hypotension in a dose-dependent manner in rats with no effect on the hypotension induced by acetylcholine, histamine and serotonin. The inhibitory effect of Pinusolide on the PAF-induced vascular permeability is less specific than the induced hypotension.
    These results suggest that Pinusolide may prove of therapeutic value in the treatment of hypotension and a molecular design of Pinusolide analogues may provide the possibility of a new PAF specific antagonists.
    Bioorg Med Chem Lett. 2006 Aug 15;16(16):4228-32.
    Gram-scale synthesis of pinusolide and evaluation of its antileukemic potential.[Pubmed: 16781150 ]

    Pinusolide (1), a known platelet-activating factor (PAF) receptor binding antagonist, was synthesized from lambertianic acid (2), a labdane-type diterpene readily accessible in multigram quantities from the Siberian pine tree.
    It was shown that 1 not only decreases the proliferation activity of tumor cells at relatively low concentrations but specifically induces apoptosis at 100 microM via the mitochondrial pathway in the Burkitt lymphoma cell line BJAB. Also, using primary lymphoblasts and leukemic cells from children with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML), a significant DNA fragmentation in pinusolide-treated cells could be detected in an ex vivo apoptosis assay.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.886 mL 14.43 mL 28.86 mL 57.7201 mL 72.1501 mL
    5 mM 0.5772 mL 2.886 mL 5.772 mL 11.544 mL 14.43 mL
    10 mM 0.2886 mL 1.443 mL 2.886 mL 5.772 mL 7.215 mL
    50 mM 0.0577 mL 0.2886 mL 0.5772 mL 1.1544 mL 1.443 mL
    100 mM 0.0289 mL 0.1443 mL 0.2886 mL 0.5772 mL 0.7215 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    16-羟基-8(17),13-赖百当二烯-15,16-内酯-19-酸; 16-Hydroxy-8(17),13-labdadien-15,16-olid-19-oic acid CFN97177 691009-85-5 C20H28O5 = 348.4 5mg QQ客服:2056216494
    松柏酸; Pinusolidic acid CFN98634 40433-82-7 C20H28O4 = 332.4 5mg QQ客服:215959384
    红松内酯; Pinusolide CFN98404 31685-80-0 C21H30O4 = 346.5 10mg QQ客服:1413575084
    19-[(beta-D-glucopyranosyl)oxy]-19-oxo-ent-labda-8(17),13-dien-16,15-olide; 19-[(beta-D-glucopyranosyl)oxy]-19-oxo-ent-labda-8(17),13-dien-16,15-olide CFN97481 919120-78-8 C26H38O9 = 494.6 5mg QQ客服:2159513211
    15-甲氧基松柏酸; 15-Methoxypinusolidic acid CFN97253 769928-72-5 C21H30O5 = 362.5 5mg QQ客服:2056216494





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