15-甲氧基松柏酸

15-Methoxypinusolidic acid

	产品编号	CFN97253
	CAS编号	769928-72-5
	分子式 = 分子量	C₂₁H₃₀O₅ = 362.5
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Diterpenoids
	植物来源	The leaves of Biota orientalis
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产品名称	产品编号	CAS编号	包装	QQ客服
15-甲氧基松柏酸	CFN97253	769928-72-5	1mg	QQ客服：215959384
15-甲氧基松柏酸	CFN97253	769928-72-5	5mg	QQ客服：215959384
15-甲氧基松柏酸	CFN97253	769928-72-5	10mg	QQ客服：215959384
15-甲氧基松柏酸	CFN97253	769928-72-5	20mg	QQ客服：215959384

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Description:

15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methoxypinusolidic acid suppresses adipocyte differentiation through the inhibition of PPARgamma-dependent adipogenic gene expression.15-Methoxypinusolidic acid attenuates glutamate-induced excitotoxicity via stabilization of [Ca2+]i homeostasis and suppression of oxidative stress possibly through the actions on the NMDA receptors.15-Methoxypinusolidic acid induced apoptosis in murine microglial cells, presumably via inhibition of the cell cycle progression.

Targets:

NOS | NO | PPAR | Calcium Channel | NF-kB | NMDAR | p38MAPK | ERK | JNK | IL Receptor | COX

In vitro:

Arch Pharm Res. 2010 Jul;33(7):1035-41.

Suppression of adipocyte differentiation by 15-methoxypinusolidic acid through inhibition of PPARγ activity.[Pubmed: 20661713]

Pinusolide and its derivative, 15-Methoxypinusolidic acid (15-MPA) are diterpenoid compounds isolated from Biota orientalis, which has been used as a Korean folk medicine for treating inflammatory disorders. Pinusolide and 15-Methoxypinusolidic acid suppress nitric oxide generation by suppressing inducible nitric oxide synthase and exerted anti-inflammatory functions, whereas other functions and regulatory mechanisms are largely unknown.
METHODS AND RESULTS:
In this study, we investigated whether pinusolide and 15-Methoxypinusolidic acid modulate adipocyte differentiation from pre-adipocytes 3T3-L1 cells. We found that 15-Methoxypinusolidic acid, not pinusolide, suppressed adipocyte differentiation in a dose-dependent manner, as revealed by lipid droplet formation and expression of adipogenic genes such as adiponectin and aP2. 15-Methoxypinusolidic acid did not affect mRNA and protein levels of PPARgamma, a key adipogenic transcription factor, whereas transcriptional activity of PPARgamma was significantly attenuated by 15-Methoxypinusolidic acid. While aP2 promoter activity was increased by ectopic overexpression of PPARgamma or by rosiglitazone-induced endogenous PPARgamma activation, PPARgamma-induced aP2 promoter activity was inhibited in the presence of 15-Methoxypinusolidic acid.
CONCLUSIONS:
These results suggest that 15-Methoxypinusolidic acid suppresses adipocyte differentiation through the inhibition of PPARgamma-dependent adipogenic gene expression.

Toxicol In Vitro. 2006 Sep;20(6):936-41.

15-Methoxypinusolidic acid from Biota orientalis attenuates glutamate-induced neurotoxicity in primary cultured rat cortical cells.[Pubmed: 16564156]

METHODS AND RESULTS:
15-Methoxypinusolidic acid (15-MPA), a pinusolide derivative isolated from Biota orientalis (Cupressaceae) leaves prevented glutamate-induced excitotoxicity in primary cultured rat cortical cells in vitro. 15-Methoxypinusolidic acid had more selectivity in protecting neurons against N-methyl-D-aspartate (NMDA)-induced neurotoxicity than that induced by kainic acid (KA). The glutamate-induced increase of intracellular calcium ([Ca2+]i) in cortical cells was effectively reduced by 15-Methoxypinusolidic acid . Moreover, 15-Methoxypinusolidic acid could successfully reduce the subsequent overproduction of nitric oxide (NO) and the level of cellular peroxide, and inhibit glutathione (GSH) depletion and lipid peroxidation induced by glutamate in our cultures.
CONCLUSIONS:
Collectively, these results suggested that 15-Methoxypinusolidic acid attenuated glutamate-induced excitotoxicity via stabilization of [Ca2+]i homeostasis and suppression of oxidative stress possibly through the actions on the NMDA receptors.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
16-羟基-8(17),13-赖百当二烯-15,16-内酯-19-酸; 16-Hydroxy-8(17),13-labdadien-15,16-olid-19-oic acid	CFN97177	691009-85-5	C₂₀H₂₈O₅ = 348.4	5mg	QQ客服：2159513211
松柏酸; Pinusolidic acid	CFN98634	40433-82-7	C₂₀H₂₈O₄ = 332.4	5mg	QQ客服：1457312923
红松内酯; Pinusolide	CFN98404	31685-80-0	C₂₁H₃₀O₄ = 346.5	10mg	QQ客服：2159513211
19-[(beta-D-glucopyranosyl)oxy]-19-oxo-ent-labda-8(17),13-dien-16,15-olide; 19-[(beta-D-glucopyranosyl)oxy]-19-oxo-ent-labda-8(17),13-dien-16,15-olide	CFN97481	919120-78-8	C₂₆H₃₈O₉ = 494.6	5mg	QQ客服：2056216494
15-甲氧基松柏酸; 15-Methoxypinusolidic acid	CFN97253	769928-72-5	C₂₁H₃₀O₅ = 362.5	5mg	QQ客服：1457312923

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.7586 mL	13.7931 mL	27.5862 mL	55.1724 mL	68.9655 mL
5 mM	0.5517 mL	2.7586 mL	5.5172 mL	11.0345 mL	13.7931 mL
10 mM	0.2759 mL	1.3793 mL	2.7586 mL	5.5172 mL	6.8966 mL
50 mM	0.0552 mL	0.2759 mL	0.5517 mL	1.1034 mL	1.3793 mL
100 mM	0.0276 mL	0.1379 mL	0.2759 mL	0.5517 mL	0.6897 mL

15-甲氧基松柏酸

15-Methoxypinusolidic acid

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