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  • 15-甲氧基松柏酸

    15-Methoxypinusolidic acid

    15-甲氧基松柏酸
    产品编号 CFN97253
    CAS编号 769928-72-5
    分子式 = 分子量 C21H30O5 = 362.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The leaves of Biota orientalis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    15-甲氧基松柏酸 CFN97253 769928-72-5 1mg QQ客服:1457312923
    15-甲氧基松柏酸 CFN97253 769928-72-5 5mg QQ客服:1457312923
    15-甲氧基松柏酸 CFN97253 769928-72-5 10mg QQ客服:1457312923
    15-甲氧基松柏酸 CFN97253 769928-72-5 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Leipzig (Germany)
  • University of Queensland (Australia)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • Sri Ramachandra University (India)
  • Texas A&M University (USA)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • Chiang Mai University (Thailand)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • University of Parma (Italy)
  • Heidelberg University (Germany)
  • Shanghai Institute of Organic Chemistry (China)
  • Universidade do Porto (Portugal)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Appl Biol Chem2022, 65:343−348.
  • J Mater Chem B.2019, 7(39):5896-5919
  • Sci Rep.2023, 13(1):21690.
  • Fitoterapia.2021, 153:104995.
  • Cell Metab.2020, S1550-4131(20)30002-4
  • Int J Anal Chem.2017, 2017:1254721
  • Exp Biol Med (Maywood).2019, 244(18):1665-1679
  • Journal of Physiology & Pathology in Korean Medicine.2018, 32(2): 106-112
  • J Cell Mol Med.2021, 25(5):2645-2654.
  • Hum Exp Toxicol.2022, 41:9603271221143713.
  • Oncotarget.2017, 8(64):108006-108019
  • Front Plant Sci.2020, 10:1705
  • Toxicol Res.2019, 35(4):371-387
  • Plants (Basel).2021, 10(7):1376.
  • Integr Med Res.2021, 10(3):100723.
  • Biomedicines.2022, 10(2):463.
  • Front Nutr.2021, 8: 687851.
  • Food Chem.2018, 262:78-85
  • Molecules.2019, 24(24),4583
  • J of the Korean Society of Cosmetics and Cosmetology2018, 399-406
  • Biochemistry.2018, 57(40):5886-5896
  • Food Sci Biotechnol.2021, 30(2):217-226.
  • Evid-Based Compl Alt2020, 7202519:13
  • ...
  • 生物活性
    Description: 15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methoxypinusolidic acid suppresses adipocyte differentiation through the inhibition of PPARgamma-dependent adipogenic gene expression.15-Methoxypinusolidic acid attenuates glutamate-induced excitotoxicity via stabilization of [Ca2+]i homeostasis and suppression of oxidative stress possibly through the actions on the NMDA receptors.15-Methoxypinusolidic acid induced apoptosis in murine microglial cells, presumably via inhibition of the cell cycle progression.
    Targets: NOS | NO | PPAR | Calcium Channel | NF-kB | NMDAR | p38MAPK | ERK | JNK | IL Receptor | COX
    In vitro:
    Arch Pharm Res. 2010 Jul;33(7):1035-41.
    Suppression of adipocyte differentiation by 15-methoxypinusolidic acid through inhibition of PPARγ activity.[Pubmed: 20661713]
    Pinusolide and its derivative, 15-Methoxypinusolidic acid (15-MPA) are diterpenoid compounds isolated from Biota orientalis, which has been used as a Korean folk medicine for treating inflammatory disorders. Pinusolide and 15-Methoxypinusolidic acid suppress nitric oxide generation by suppressing inducible nitric oxide synthase and exerted anti-inflammatory functions, whereas other functions and regulatory mechanisms are largely unknown.
    METHODS AND RESULTS:
    In this study, we investigated whether pinusolide and 15-Methoxypinusolidic acid modulate adipocyte differentiation from pre-adipocytes 3T3-L1 cells. We found that 15-Methoxypinusolidic acid, not pinusolide, suppressed adipocyte differentiation in a dose-dependent manner, as revealed by lipid droplet formation and expression of adipogenic genes such as adiponectin and aP2. 15-Methoxypinusolidic acid did not affect mRNA and protein levels of PPARgamma, a key adipogenic transcription factor, whereas transcriptional activity of PPARgamma was significantly attenuated by 15-Methoxypinusolidic acid. While aP2 promoter activity was increased by ectopic overexpression of PPARgamma or by rosiglitazone-induced endogenous PPARgamma activation, PPARgamma-induced aP2 promoter activity was inhibited in the presence of 15-Methoxypinusolidic acid.
    CONCLUSIONS:
    These results suggest that 15-Methoxypinusolidic acid suppresses adipocyte differentiation through the inhibition of PPARgamma-dependent adipogenic gene expression.
    Toxicol In Vitro. 2006 Sep;20(6):936-41.
    15-Methoxypinusolidic acid from Biota orientalis attenuates glutamate-induced neurotoxicity in primary cultured rat cortical cells.[Pubmed: 16564156]

    METHODS AND RESULTS:
    15-Methoxypinusolidic acid (15-MPA), a pinusolide derivative isolated from Biota orientalis (Cupressaceae) leaves prevented glutamate-induced excitotoxicity in primary cultured rat cortical cells in vitro. 15-Methoxypinusolidic acid had more selectivity in protecting neurons against N-methyl-D-aspartate (NMDA)-induced neurotoxicity than that induced by kainic acid (KA). The glutamate-induced increase of intracellular calcium ([Ca2+]i) in cortical cells was effectively reduced by 15-Methoxypinusolidic acid . Moreover, 15-Methoxypinusolidic acid could successfully reduce the subsequent overproduction of nitric oxide (NO) and the level of cellular peroxide, and inhibit glutathione (GSH) depletion and lipid peroxidation induced by glutamate in our cultures.
    CONCLUSIONS:
    Collectively, these results suggested that 15-Methoxypinusolidic acid attenuated glutamate-induced excitotoxicity via stabilization of [Ca2+]i homeostasis and suppression of oxidative stress possibly through the actions on the NMDA receptors.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7586 mL 13.7931 mL 27.5862 mL 55.1724 mL 68.9655 mL
    5 mM 0.5517 mL 2.7586 mL 5.5172 mL 11.0345 mL 13.7931 mL
    10 mM 0.2759 mL 1.3793 mL 2.7586 mL 5.5172 mL 6.8966 mL
    50 mM 0.0552 mL 0.2759 mL 0.5517 mL 1.1034 mL 1.3793 mL
    100 mM 0.0276 mL 0.1379 mL 0.2759 mL 0.5517 mL 0.6897 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    16-羟基-8(17),13-赖百当二烯-15,16-内酯-19-酸; 16-Hydroxy-8(17),13-labdadien-15,16-olid-19-oic acid CFN97177 691009-85-5 C20H28O5 = 348.4 5mg QQ客服:215959384
    松柏酸; Pinusolidic acid CFN98634 40433-82-7 C20H28O4 = 332.4 5mg QQ客服:2159513211
    红松内酯; Pinusolide CFN98404 31685-80-0 C21H30O4 = 346.5 10mg QQ客服:1413575084
    19-[(beta-D-glucopyranosyl)oxy]-19-oxo-ent-labda-8(17),13-dien-16,15-olide; 19-[(beta-D-glucopyranosyl)oxy]-19-oxo-ent-labda-8(17),13-dien-16,15-olide CFN97481 919120-78-8 C26H38O9 = 494.6 5mg QQ客服:1457312923
    15-甲氧基松柏酸; 15-Methoxypinusolidic acid CFN97253 769928-72-5 C21H30O5 = 362.5 5mg QQ客服:2056216494

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